Structural insights into the extraction mechanism of cobalt(II) with dinonylnaphthalene sulfonic acid and 2-ethylhexyl 4-pyridinecarboxylate ester

<p>In this work, to elucidate the synergistic extraction mechanism of cobalt(II) with dinonylnaphthalene sulfonic acid (HDNNS) and 2-ethylhexyl 4-pyridinecarboxylate ester (L), hexaaquacobalt(II) naphthalene-2-sulfonate (compound <b>1</b>) was prepared using naphthalene-2-sulfonic acid (HNS, the short chain analog of HDNNS) and di-methyl isonicotinate tetraaquacobalt(II) naphthalene-2-sulfonate (compound <b>2</b>) was prepared using methyl isonicotinate (L^I, a short chain analog of 2-ethylhexyl 4-pyridinecarboxylate ester) and HNS; the compounds were studied by single crystal X-ray diffraction. Moreover, <b>2</b> and the actual extracted cobalt(II) complex were further investigated by Fourier transform infrared spectroscopy (FT-IR) and electrospray ionization mass spectrometry (ESI-MS). The results indicated that the actual extracted cobalt(II) complex possesses a similar coordination structure as <b>2</b>. Combined with the results obtained by single crystal X-ray diffraction of <b>1</b> and <b>2</b>, FT-IR and ESI-MS of <b>2</b> and the actual extracted cobalt(II) complex, it is reasonable to conclude that the extracted cobalt(II) complex with the actual synergistic mixture is much more stable than the cobalt(II) complex with HDNNS alone. Therefore, the extraction selectivity cobalt(II) is effectively enhanced with the addition of 2-ethylhexyl 4-pyridinecarboxylate ester to HDNNS.</p

¹⁸F‑Alanine Derivative Serves as an ASCT2 Marker for Cancer Imaging

Amino acids derivative are well established molecular probes for diagnosis of a variety of cancer using positron emission tomography (PET). Recently, boramino acid (BAAs) was found as a prospective molecular platform for developing PET tracer. The objective of this study was to develop a ¹⁸F-labeled alanine derivative through displacing its carboxylate by trifluoroborate as a selective ASCT2 marker for cancer imaging. ¹⁸F-Ala-BF₃ was first evaluated in healthy FVB/N mice <i>in vivo</i>, exhibiting rapid renal clearance with almost negligible uptake in stomach (1.53 ± 0.31%ID/g). Notable uptake was observed in thyroid (3.71 ± 0.49%ID/g, 40 min post injection), of which the uptake was significantly inhibited by co-injection with natural L-alanine. In addition, we further established ¹⁸F-Ala-BF₃ on a human gastric cancer cell (BGC-823) xenografts bearing mouse model. Dynamic PET-CT scan revealed the optimal time window for tumor imaging, it was between 40 and 60 min post injection, when the BGC-823 xenografts uptake was 5.49 ± 1.47%ID/g (<i>n</i> = 4), and the tumor-to-stomach, tumor-to-blood, tumor-to-muscle, and tumor-to-brain ratios were 3.27 ± 1.53, 3.80 ± 1.48, 3.47 ± 1.48, and 6.20 ± 1.47, respectively

DataSheet_1_Association between dietary antioxidant levels and chronic obstructive pulmonary disease: a mediation analysis of inflammatory factors.docx

IntroductionThe development of chronic obstructive pulmonary disease (COPD) is strongly associated with oxidative stress, but it is unclear whether increasing dietary antioxidant intake reduces the risk of COPD. Therefore, this study assessed the association between antioxidant intake and COPD in US adults aged ≥ 40 years and further examined the correlation using the Composite Dietary Antioxidant Index (CDAI).MethodsThe study included 8,257 US adults aged ≥ 40 years using data from the National Health and Nutrition Examination Survey (NHANES) for three cycles from 2007-2012. Multivariate logistic regression models were used to calculate the correlation between antioxidant intake and CDAI with COPD. Restricted cubic spline was further used to explore the exposure-response relationship. Mediation analysis was used to explore the role of inflammatory factors in the association between CDAI and COPD.ResultsThis study included 8257 participants (4111 women [weighted, 50.7%]; mean [SD] age, 58.8 [11.2] years). In a multivariable-adjusted model of single antioxidant intake, a linear downward association between carotenoid intake and the incidence of COPD (P for trend = 0.052; Pnon- linear = 0.961). In a multivariable adjusted model for CDAI, this association is similarly present (P for trend = 0.018; Pnon-linear = 0.360). Multiple linear regression modeling showed that leukocytes (P = 0.002), alkaline phosphatase (PConclusionThe risk of COPD decreased with increased carotenoid intake and CDAI. In addition, CDAI has been found to be strongly associated with inflammatory factors and can reduce the incidence of COPD by mediating inflammatory factors.</p

Additional file 1 of Genomics insights into flowering and floral pattern formation: regional duplication and seasonal pattern of gene expression in Camellia

Additional file 1: Fig. S1. The karyotyping and Kmer-based analyses of the cjaND genome. Fig. S2. The Hi-C heatmap shows the interaction of the chromosome. Fig. S3. The segregation patterns of the genetic makers. Fig. S4. The evolution and expression pattern of CjAGs. Fig. S5. Co-expression network analysis of CjAG1 and CjAG2. Fig. S6. Identification of annual rhythmic genes in C. japonica. Fig. S7. Identification of annual rhythmic genes in C. azalea. Fig. S8. The relationship of co-expression module of common rhythmic genes. Fig. S9. The seasonal expression genes participating in different pathways in C. japonica and C. azalea. Fig. S10. Identification of FT genes from C. japonica and C. azalea