From Ketones, Amines, and Carbon Monoxide to 4‑Quinolones: Palladium-Catalyzed Oxidative Carbonylation

A novel method of palladium-catalyzed oxidative carbonylation of ketones, amines, and carbon monoxide for the synthesis of 4-quinolones has been developed. This protocol provides a straightforward route to construct useful 4-quinolone derivatives from inexpensive chemicals

Electro-oxidative C(sp3)–H Amination of Azoles via Intermolecular Oxidative C(sp3)–H/N–H Cross-Coupling

A method for electrooxidative C­(sp3)–H amination via intermolecular oxidative C­(sp3)–H/N–H cross-coupling has been developed under metal- and oxidant-free conditions. The C­(sp3)–H bonds adjacent to oxygen, nitrogen, and sulfur atoms could all react smoothly with various amines to give the corresponding products with moderate to good yields (30–93%). In addition, the C­(sp3)–H bonds of benzylic and allylic are also tolerated in this reaction. A preliminary mechanistic study indicates that the C–H cleavage of tetrahydrofuran is probably not involved in the rate-determining step