2 research outputs found
Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice
The
overproduction of reactive oxygen species (ROS) is central
to the progression of inflammatory bowel disease (IBD), which may
be the potential therapeutic target. Prussian blue (PB) nanoparticles
with good biosafety can act as an artificial nanozyme, effectively
scavenging ROS. To date, PB-based nanomaterials have not been developed
and utilized for treatment of IBD. In this study, poly(vinylpyrrolidone)-modified
Prussian blue (PPB) nanoparticles are constructed with good physiological
stability and biosafety by a simple and efficient method. The prepared
PPBs with capabilities of scavenging ROS and inhibiting proinflammatory
cytokine significantly reduce colitis in mice without distinct side
effects via intravenous administration. This report provides a demonstration
of the protective effect of PB-based nanomedicine against IBD in living
animals, offering hope and a potential alternative treatment option
for patients suffering from IBD
Design of Phase-Changeable and Injectable Alginate Hydrogel for Imaging-Guided Tumor Hyperthermia and Chemotherapy
The
objective of the present study was to construct an alginate (AG)-based
phase-changeable and injectable hydrogel for imaging-guided tumor
hyperthermia and chemotherapy. Based on the binding between the α-l-guluronic blocks of AG and calcium ions, the AG/MoS<sub>2</sub>/Bi<sub>2</sub>S<sub>3</sub>-poly(ethylene glycol) (MBP)/doxorubicin
(DOX) solution formed a cross-linked hydrogel to simultaneously encapsulate
MBP nanosheets and DOX within the hydrogel matrix. The in situ formed
hydrogel can act as a reservoir to control the release of entrapped
drug molecules, and the doped MBP nanosheets and DOX can realize computed
tomography/photoacoustic dual-modal imaging-guided in vivo tumor photothermal
therapy and chemotherapy, respectively. The AG/MBP/DOX hydrogel exhibited
excellent photothermal conversion properties with mass extinction
coefficient of 45.1 L/g/cm and photothermal conversion efficiency
of 42.7%. Besides, the heat from the photothermal transformation of
MBP can promote drug diffusion from the hydrogel to realize on-demand
drug release. Additionally, the hydrogel system can restrain MBP and
DOX from entering into the blood stream during therapy, and therefore
substantially decrease their side effects on normal organs. More importantly,
the drug loading of the AG hydrogel was general and can be extended
to the encapsulation of antibiotics, such as amoxicillin, for the
prevention of postoperative infections