Development of China’s first space-borne aerosol-cloud high-spectral-resolution lidar: retrieval algorithm and airborne demonstration

Aerosols and clouds greatly affect the Earth’s radiation budget and global climate. Light detection and ranging (lidar) has been recognized as a promising active remote sensing technique for the vertical observations of aerosols and clouds. China launched its first space-borne aerosol-cloud high-spectral-resolution lidar (ACHSRL) on April 16, 2022, which is capable for high accuracy profiling of aerosols and clouds around the globe. This study presents a retrieval algorithm for aerosol and cloud optical properties from ACHSRL which were compared with the end-to-end Monte-Carlo simulations and validated with the data from an airborne flight with the ACHSRL prototype (A2P) instrument. Using imaging denoising, threshold discrimination, and iterative reconstruction methods, this algorithm was developed for calibration, feature detection, and extinction coefficient (EC) retrievals. The simulation results show that 95.4% of the backscatter coefficient (BSC) have an error less than 12% while 95.4% of EC have an error less than 24%. Cirrus and marine and urban aerosols were identified based on the airborne measurements over different surface types. Then, comparisons were made with U.S. Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) profiles, Moderate-resolution Imaging Spectroradiometer (MODIS), and the ground-based sun photometers. High correlations (R > 0.79) were found between BSC (EC) profiles of A2P and CALIOP over forest and town cover, while the correlation coefficients are 0.57 for BSC and 0.58 for EC over ocean cover; the aerosol optical depth retrievals have correlation coefficient of 0.71 with MODIS data and show spatial variations consistent with those from the sun photometers. The algorithm developed for ACHSRL in this study can be directly employed for future space-borne high-spectral-resolution lidar (HSRL) and its data products will also supplement CALIOP data coverage for global observations of aerosol and cloud properties

Combination of Immunotherapy With Targeted Therapy: Theory and Practice in Metastatic Melanoma

Metastatic melanoma is the most aggressive and obstinate skin cancer with poor prognosis. Variant novel applicable regimens have emerged during the past decades intensively, while the most profound approaches are oncogene-targeted therapy and T-lymphocyte mediated immunotherapy. Although targeted therapies generated remarkable and rapid clinical responses in the majority of patients, acquired resistance was developed promptly within months leading to tumor relapse. By contrast, immunotherapies elicited long-term tumor regression. However, the overall response rate was limited. In view of the above, either targeted therapy or immunotherapy cannot elicit durable clinical responses in large range of patients. Interestingly, the advantages and limitations of these regimens happened to be complementary. An increasing number of preclinical studies and clinical trials proved a synergistic antitumor effect with the combination of targeted therapy and immunotherapy, implying a promising prospect for the treatment of metastatic melanoma. In order to achieve a better therapeutic effectiveness and reduce toxicity in patients, great efforts need to be made to illuminate multifaceted interplay between targeted therapy and immunotherapy

Occurrence and Discrepancy of Surface and Column Mole Fractions of CO2 and CH4 at a Desert Site in Dunhuang, Western China

Carbon dioxide (CO2) and methane (CH4) are the two major radiative forcing factors of greenhouse gases. In this study, surface and column mole fractions of CO2 and CH4 were first measured at a desert site in Dunhuang, west China. The average column mole fractions of CO2 (XCO2) and CH4 (XCH4) were 413.00 ± 1.09 ppm and 1876 ± 6 ppb, respectively, which were 0.90 ppm and 72 ppb lower than their surface values. Diurnal XCO2 showed a sinusoidal mode, while XCH4 appeared as a unimodal distribution. Ground observed XCO2 and XCH4 were compared with international satellites, such as GOSAT, GOSAT-2, OCO-2, OCO-3, and Sentinel-5P. The differences between satellites and EM27/SUN observations were 0.26% for XCO2 and −0.38% for XCH4, suggesting a good consistency between different satellites and ground observations in desert regions in China. Hourly XCO2 was close to surface CO2 mole fractions, but XCH4 appeared to have a large gap with CH4, probably because of the additional chemical removals of CH4 in the upper atmosphere. It is necessary to carry out a long-term observation of column mole fractions of greenhouse gases in the future to obtain their temporal distributions as well as the differences between satellites and ground observations

Summary: Lidar Observations from ADM-Aeolus and EarthCARE-Validation, Study of Long-range Transport of Aerosol and Preparation of a Future Chinese CO2 Lidar Mission

Summary of status and outlook for the three subprojects: Preparation of Cal/Val of spaceborne Aerosol and Carbon dioxide Detection Lidar (ACDL) by ground-based and airborne sounding instruments observations, Validation of ADM-Aeolus by airborne and ground-based wind lidar observations, and Long-range dust transport and validation using ground-based and satellite lidar observations

Simulation and Performance Evaluation of Laser Heterodyne Spectrometer Based on CO₂ Absorption Cell

The laser heterodyne radiometer (LHR) has the advantages of miniaturization, low cost, and high spectral-resolution as a ground-verification instrument for satellite observation of atmospheric trace-gas concentration. To verify the accuracy of LHR measurements, a new performance evaluation method is presented here, based on an ASE source and a CO2 absorption cell in the laboratory. Preliminary simulation analysis based on the system parameters of LHR is carried out for the performance analysis and data processing of this new combined test system. According to the simulation results, at wavelength deviation of fewer than 30 MHz, the retrieval error, which increases with bandwidth, can obtain an accuracy of 1 ppm within the bandwidth range of the photodetector (1.2 GHz) when this instrument line shape (ILS) is calibrated. Meanwhile, when the filter bandwidth is less than 200 MHz, the maximum error without ILS correction does not exceed 0.07 ppm. Moreover, with an ideal 60 MHz bandpass filter without ILS correction, LHR’s signal-to-noise ratio (SNR) should be greater than 20 to achieve retrieval results of less than 1 ppm. When the SNR is 100, the retrieval error is 0.206 and 0.265 ppm, corresponding to whether the system uncertainties (temperature and pressure) are considered. Considering all the error terms, the retrieval error (geometrically added) is 0.528 ppm at a spectral resolution of 0.004 cm−1, which meets the measurement accuracy requirement of 1 ppm. In the experiment, the retrieval and analysis of the heterodyne signals are performed for different XCO2 with [400 ppm, 420 ppm] in the absorption cell. Experimental results match well with the simulation, and confirm the accuracy of LHR with an error of less than 1 ppm with an SNR of 100. The LHR will be used to measure atmospheric-CO2 column concentrations in the future, and could be effective validation instruments on the ground for spaceborne CO2-sounding sensors

Validation of double-pulse 1572 nm integrated path differential absorption lidar measurement of carbon dioxide

A ground-based double-pulse 1572 nm integrated path differential absorption (IPDA) lidar was developed for carbon dioxide (CO2) column concentrations measurement. The lidar measured the CO2 concentrations continuously by receiving the scattered echo signal from a building about 1300 m away. The other two instruments of TDLAS and in-situ CO2 analyzer measured the CO2 concentrations on the same time. A CO2 concentration measurement of 430 ppm with 1.637 ppm standard error was achieved

Field Performance of All-Fiber Pulsed Coherent Doppler Lidar

Coherent Doppler lidar (CDL) has been a powerful instrument to measure atmospheric wind velocity. In this work, an 1.5 μm all-fiber pulsed CDL has been developed and deployed to measure wind profiles in campaign experiment in 2018. The CDL has 0.1-5 km detection range with range resolution of 30 m, temporal resolution of 16 s at Velocity-Azimuth-Display (VAD) mode. Field experiments were implemented and the wind vector profiles were retrieved. As compared with sounding balloon, the discrepancy of wind speed and direction are nearly 0.7 m/s and 5 degrees, respectively. It shows that the CDL is a powerful tool for wind speeds measurement in lower atmospheric troposphere

Validation of double-pulse 1572 nm integrated path differential absorption lidar measurement of carbon dioxide

A ground-based double-pulse 1572 nm integrated path differential absorption (IPDA) lidar was developed for carbon dioxide (CO2) column concentrations measurement. The lidar measured the CO2 concentrations continuously by receiving the scattered echo signal from a building about 1300 m away. The other two instruments of TDLAS and in-situ CO2 analyzer measured the CO2 concentrations on the same time. A CO2 concentration measurement of 430 ppm with 1.637 ppm standard error was achieved