SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

Effect of Side Blowing on Fluid Flow and Mixing Phenomenon in Gas-Stirred Ladle

To investigate the gas agitation characteristics of side blowing, the fluid flow and mixing phenomenon in a 1:3 scale model ladle of a 150 t industrial gas-stirred ladle with bottom and side plugs were studied by using physical and numerical modelings together. Side blowing enhanced the horizontal flow of water in the model ladle. Compared with bottom blowing, side blowing that is close to the ladle bottom with more than two plugs increases the average velocity of water, which represents the agitation power, improves the uniformity of water velocity distribution, reduces the stagnant region rate, and shortens the mixing time. The mixing time of dual bottom plugs is almost 1.5 times of that of four side plugs at 116 mm under the same flow rate. The mixing time is not only influenced by the agitation power but also by the uniformity of water velocity distribution. Although the agitation power of four side plugs at 450 mm under the flow rate of 1.8 m3/h is about 1.5 times of that at 116 mm with 0.6 m3/h. The mixing time of the 1.8 m3/h flow rate is about 1.2 times of that of the 0.6 m3/h because of the different water velocity distributions

Effect of Side Blowing on Fluid Flow and Mixing Phenomenon in Gas-Stirred Ladle

To investigate the gas agitation characteristics of side blowing, the fluid flow and mixing phenomenon in a 1:3 scale model ladle of a 150 t industrial gas-stirred ladle with bottom and side plugs were studied by using physical and numerical modelings together. Side blowing enhanced the horizontal flow of water in the model ladle. Compared with bottom blowing, side blowing that is close to the ladle bottom with more than two plugs increases the average velocity of water, which represents the agitation power, improves the uniformity of water velocity distribution, reduces the stagnant region rate, and shortens the mixing time. The mixing time of dual bottom plugs is almost 1.5 times of that of four side plugs at 116 mm under the same flow rate. The mixing time is not only influenced by the agitation power but also by the uniformity of water velocity distribution. Although the agitation power of four side plugs at 450 mm under the flow rate of 1.8 m3/h is about 1.5 times of that at 116 mm with 0.6 m3/h. The mixing time of the 1.8 m3/h flow rate is about 1.2 times of that of the 0.6 m3/h because of the different water velocity distributions

The complete mitochondrial genome of Metapenaeus ensis

The complete mitochondrial genome sequence of Metapenaeus ensis was obtained by PCR, containing 37 genes with 13 protein-coding genes, 22 transfer RNAs (tRNAs), two ribosomal RNAs (rRNAs) and a non-coding control region