Ethyl 3-{5-[(diethyl­amino)meth­yl]isoxazol-3-yl}-2-phenyl­pyrazolo[1,5-a]pyridine-5-carboxyl­ate

In the title compound, C24H26N4O3, the pyrazolo[1,5-a]pyridine ring system makes dihedral angles of 38.130 (3) and 30.120 (3)°, respectively, with the isoxazole and phenyl rings. In the crystal, two mol­ecules are linked by a pair of C—H⋯N hydrogen bonds, forming a centrosymmetric dimer. A weak intra­molecular C—H⋯O inter­action is also present

Traditional Chinese Herbal Patch for Short-Term Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial

Objective. To assess the short-term efficacy and safety of two kinds of Traditional Chinese herbal patches, Fufang Nanxing Zhitong Gao (FNZG) and Shangshi Jietong Gao (SJG), for painful knee osteoarthritis (OA). Methods. Patients were randomly enrolled in a double-blind, placebo-controlled study to receive FNZG (n=60), SJG (n=60), or placebo patch (n=30) for 7 days. Outcome measures included visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Traditional Chinese Medicine Syndrome Questionnaire (TCMSQ) subscale. Results. Although there was no significant difference among, three groups in short-term pain management, patients receiving FNZG got significant improvement in symptom of fear of coldness as compared with placebo patch (P=0.029). The most common local adverse events of rash, itching, erythema, and slightly damaged skin were observed in 7% of participants. Conclusions. FNZG may be a useful treatment for symptom of knee OA and merits long-term study in broader populations

The multi-timescale temporal patterns and dynamics of land surface temperature using Ensemble Empirical Mode Decomposition

Temporal variation patterns of Land Surface Temperature (LST) under different time scales are crucial in understanding the response of urban thermal environment to different forcings. However, there is no integrated toolset to extract such patterns from satellite remotely sensed time series LST (TSLST) data. This paper presents a workflow to extract the multi-timescale temporal patterns and dynamics from nonlinear and non-stationary TSLST data by taking Wuhan, China as case study. The 8-day MODerate-resolution Imaging Spectroradiometer (MODIS) satellite image products spanning the 2003–2017 period are used to generate a TSLST dataset with continuous and smooth surfaces on the monthly basis through the non-parametric Multi-Task Gaussian Process Modeling (MTGP). The study area is segmented into multiple time series clusters by k-means to bridge with urban planning in terms of research and implementation scale. Then, temporal patterns including annual, interannual components, and overall trends are reconstructed based on the components with characteristic time scales decomposed by the adaptive Ensemble Empirical Mode Decomposition (EEMD) method. The generated patterns of the 17 time series clusters are interpreted from the perspective of earth revolution, meteorological cycles and urbanization. Specifically, the annual components which are mainly generated by earth revolution reveal consistent rhythmic patterns among the time series. The interannual components preserve similar shapes although they differ in amplitudes. The overall shape is basically consistent with that of air temperature of Central China, which may be mainly induced by the El Niño-Southern Oscillation (ENSO) phenomenon. The overall trends which exert considerable differences are grouped into three types by shape. Such differences may be potentially caused by the inconsistent levels of localized urbanization, afforestation or circular economy development. This study facilitates the understanding of TSLST patterns and human-environment interactions. The proposed workflow can be utilized for other cities and potentially used for comparison among different cities

TAMM41 is required for heart valve differentiation via regulation of PINK-PARK2 dependent mitophagy

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