Screening and selection process for articles.

<p>Screening and selection process for articles.</p

Results of the overall analysis.

<p>Results of the overall analysis.</p

Results of subgroup analysis of different parts of the CC.

<p>Results of subgroup analysis of different parts of the CC.</p

Results of publication bias analysis.

<p>Bias was analyzed with Egger’s method. t = 0.6, <i>P</i> = 0.55.</p

Results of subgroup analysis of different types of schizophrenia.

<p>Results of subgroup analysis of different types of schizophrenia.</p

Study characteristics of included articles.

<p>Study characteristics of included articles.</p

Additional file 1: of Differential mitochondrial DNA copy number in three mood states of bipolar disorder

Excluded neurological diseases and other serious physical conditions in the study. (DOCX 15 kb

Comparison of mtDNA copy number between the MDD group and the HC group, and comparison of mtDMA copy number within the MDD group.

<p>MDD: major depressive disorder; HC: healthy controls; HDRS: Hamilton Depression Rating Scale.</p><p>p calculated by the t-test.</p><p>^* Patients are considered to be currently suffered from depression with a score of ≥18 on the HDRS, while are defined as being in remission if they had an HDRS score less than 18.</p

Characteristics of EOS and control groups in fMRI analysis.

<p>Characteristics of EOS and control groups in fMRI analysis.</p

Relative mtDNA copy number of MDD patients and HC.

<p>There is no significant difference in mtDNA copy number between MDD and HC.</p