Number of channels with different thickness of dielectric slab <i>C</i>.

Number of channels with different thickness of dielectric slab C.</p

Transmittance spectra at different number of periods values.

(a-d) The number of periods is N = 3, N = 4, N = 5, N = 6, respectively.</p

S1 Data -

We studied the optical fractal effect of the one-dimensional distributed feedback Bragg photonic crystals formed by semiconductor GaAs and dielectric TiO2. Light wave is transmitted in the intermediate dielectric slab and reflected back by the periodic photonic crystals at both ends, forming multiple fractal resonance output. The transmission channels expand exponentially by thickening the bulk in a cryogenic environment. The quality factor of each fractal resonant state improves with a greater periodic number of crystals. Furthermore, central wave of resonance has a blue-shift as the external pressure increases, while the influence of environment temperature on the fractal resonance could be ignored. It is hoped that our study can highlight the potential of these findings for designing multi-channel communication filters in cryogenic environments.</div

Schematic diagram of the one-dimensional distributed feedback Bragg photonic crystal structure (<i>AB</i>)^<i>N</i><i>C</i>(<i>BA</i>)^<i>N</i>, with <i>N =</i> 3.

Schematic diagram of the one-dimensional distributed feedback Bragg photonic crystal structure (AB)NC(BA)N, with N = 3.</p

Fig 7 -

(a) The transmittance in the parameter space composed of temperature and normalized frequency. (b) The transmittance in the parameter space composed of pressure and normalized frequency. (c) The transmittance spectra corresponding to the external static pressures of P = 10 GPa, 11 GPa, and 12 GPa, respectively.</p

Transmittance spectra with different initial thickness of dielectric slab <i>C</i>.

(a-d) The initial thickness is set to dco = 3dao, dco = 9dao, dco = 27dao, dco = 81dao, respectively.</p

Electric field distribution of the optical fractal states in the transmission spectrum with different initial thickness of dielectric slab <i>C</i>.

(a-d) The initial thickness is set to dco = 3dao, dco = 9dao, dco = 27dao, dco = 81dao, respectively.</p

Electric field distribution of the optical fractal states in the transmission spectrum with different number of periods.

(a-d) The number of periods is N = 3, N = 4, N = 5, N = 6, respectively.</p

Fig 3 -

(a) The quality factor of the channel C1 varying with the number of periods. (b) The central wavelength of the channel C1 varying with the number of periods.</p

Table1_Establishing a glutamine metabolism-based model for predicting the prognosis of low-grade glioma.xlsx

Background: The natural history of patients with low-grade glioma (LGG) varies widely, but most patients eventually deteriorate, leading to poor prognostic outcomes. We aim to develop biological models that can accurately predict the outcome of LGG prognosis.Methods: Prognostic genes for glutamine metabolism were searched by univariate Cox regression, and molecular typing was constructed. Functional enrichment analysis was done to evaluate potential prognostic-related pathways by analyzing differential genes in different subtypes. Enrichment scores of specific gene sets in different subtypes were measured by gene set enrichment analysis. Different immune infiltration levels among subtypes were calculated using algorithms such as CIBERSORT and ESTIMATE. Gene expression levels of prognostic-related gene signatures of glutamine metabolism phenotypes were used to construct a RiskScore model. Receiver operating characteristic curve, decision curve and calibration curve analyses were used to evaluate the reliability and validity of the risk model. The decision tree model was used to determine the best predictor variable ultimately.Results: We found that C1 had the worst prognosis and the highest level of immune infiltration, among which the highest macrophage infiltration can be found in the M2 stage. Moreover, most of the pathways associated with tumor development, such as MYC_TARGETS_V1 and EPITHELIAL_MESENCHYMAL_TRANSITION, were significantly enriched in C1. The wild-type IDH and MGMT hypermethylation were the most abundant in C1. A five-gene risk model related to glutamine metabolism phenotype was established with good performance in both training and validation datasets. The final decision tree demonstrated the RiskScore model as the most significant predictor of prognostic outcomes in individuals with LGG.Conclusion: The RiskScore model related to glutamine metabolism can be an exceedingly accurate predictor for LGG patients, providing valuable suggestions for personalized treatment.</p