Best model for association between telomere length (LTL) and lifestyle and laboratory parameters in a step wise multivariable model including all significant factors from univariable analyses in all subjects.

<p>Dependent variable is LTL shortening (LTL of less than the mean value was marked as 1, LTL of longer than the mean value was marked as 0).</p

Best model for association of cardiovascular risk factors and LTL to stroke in a step wise multivariable model including all significiant risk factors from univariable analyses between stroke and sibling subjects.

<p>Best model for association of cardiovascular risk factors and LTL to stroke in a step wise multivariable model including all significiant risk factors from univariable analyses between stroke and sibling subjects.</p

AlncRNA HULC as an effective biomarker for surveillance of the outcome of cancer: A meta-analysis

<div><p>Purpose</p><p>High expression of highly upregulated in iver cancer (HULC) has been found associated with increased metastasis and poor prognosis with cancer. This meta-analysis aimed to determine the pooled effect of HULC on metastasis and prognosis of cancers.</p><p>Method</p><p>The studies were accessed using multiple databases. RevMan5.3 and STATA14.0 were used to estimate pooled effects, the heterogeneity among studies, and publication bias for the association of HULC and overall survival (OS).</p><p>Results</p><p>A total of 9 studies of 966 cancer patients were included. Risk of lymph node metastasis was increased with high versus low HULC expression (pooled odds ratio [OR] = 4.83, 95% confidence interval [CI] 1.59–14.63) as was distant metastasis (pooled OR = 5.44, 95% CI 2.33–12.74). Furthermore, OS time was shortened with high HULC expression (pooled hazard ratio [HR] = 1.48, 95% CI 1.03–2.12), especially in Chinese patients (pooled HR = 2.04, 95% CI 1.55–2.68), and risk of recurrence was increased (pooled OR = 6.68, 95% CI 2.77–16.13).</p><p>Conclusion</p><p>HULC might be a potential biomarker for therapy and prognosis surveillance in cancers.</p></div

Correlations of lifestyle and laboratory parameters with LTL.

<p>Correlations of lifestyle and laboratory parameters with LTL.</p

Forest plot of association between HULC expression and recurrence.

<p>Forest plot of association between HULC expression and recurrence.</p

Begg’s funnel plot with pseudo 95% CIs testing publication bias with the association between HULC and OS.

<p>Begg’s funnel plot with pseudo 95% CIs testing publication bias with the association between HULC and OS.</p

Basic data for all included studies in the meta-analysis.

<p>Basic data for all included studies in the meta-analysis.</p

Flow of the studies in the meta-analysis.

<p>HULC, highly upregulated in liver cancer.</p

Sensitivity analysis for the studies that resulted in loss of significance after omission.

<p>Sensitivity analysis for the studies that resulted in loss of significance after omission.</p

Forest plot of association between HUCL expression and overall survival (OS) under the random-effects model.

<p>Data are hazard ratios (HRs) and 95% CIs. <b>Abbreviations:</b> SE, standard error; IV, inverse variance methods; CI, confidence interval, df, degree of freedom.</p