1 research outputs found
Fabrication of Reduced Graphene Oxide and Sliver Nanoparticle Hybrids for Raman Detection of Absorbed Folic Acid: A Potential Cancer Diagnostic Probe
Reduced graphene oxide (RGO) and
silver nanoparticle (AgNP) hybrids (RGO-AgNP) were prepared by a facile
one-pot method using Poly (N-vinyl-2-pyrrolidone) as reductant and
stabilizer. Folic acid (FA) molecules were attached to the RGO-AgNP
by physisorption for targeting specific cancer cells with folate receptors
(FRs) and using as Raman reporter molecules. The internalization of
the FA loaded RGO-AgNP (RGO-AgNP-FA) inside the FRs-positive cancer
cell was confirmed by confocal laser scanning and transmission electron
microscopy. The Raman signals of the FA in live cancer cells were
detected by confocal Raman spectroscope at 514 nm excitation, indicating
that the RGO-AgNP-FA material has great potential as a Raman probe
for cancer diagnosis in vitro