Copper-Catalyzed One-Pot Synthesis of Unsymmetrical Arylurea Derivatives via Tandem Reaction of Diaryliodonium Salts with <i>N</i>‑Arylcyanamide

An efficient “one-pot” approach to multiple substituted ureas from <i>N</i>-arylcyanamide and diaryliodonium salts has been presented. The two-step procedure involved the weak base-promoted chemoselective arylation of secondary amines with diaryliodonium and Cu-catalyzed nucleophilic addition of <i>N</i>-arylcyanamide with second diaryliodonium. The diverse unsymmetrical arylureas were obtained in up to 91% yield for 29 examples

Additional file 1: of Non-medical financial burden in tuberculosis care: a cross-sectional survey in rural China

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