The Role of Loan Loss Provisions in Earnings Management and Capital Management: The Chinese Experience

Banks’ loan loss provisions play an important role in bank stability and soundness. It can help banks prevent credit risk, smooth income, manage regulatory capital and also improve their performance. This paper examines the loan loss provisions behaviours in Chinese banking system and how they are correlated with the earnings management and capital management. Based on 260 banks over the period of 2011-2017, both the Fixed Effects model and the System Generalized Method of Moments estimator are used to assist our analysis. The findings indicate that loan loss provisions are not used as a tool for income smoothing since the results show that banks may decrease their provisions when their earnings increase. However, there is a significant proof for capital management in Chinese banks, which indicates that Chinese banks may use loan loss provisions to manage their capital ratios in order to meet regulatory requirements. The lagged dependent variable is also significant, showing that Chinese banks may adjust provisions according to the amount in previous years. In terms of other control variables, the non-performing loans, the gross loans, the GDP growth rate and the unemployment rate are all significant, indicating that they may have great impacts on loan loss provisions behaviours in China

An Integrated Contraflow Strategy for Multimodal Evacuation

To improve the efficiency of multimodal evacuation, a network aggregation method and an integrated contraflow strategy are proposed in this paper. The network aggregation method indicates the uncertain evacuation demand on the arterial subnetwork and balances accuracy and efficiency by refining the local road subnetworks. The integrated contraflow strategy contains three arterial configurations: noncontraflow to shorten the strategy setup time, full-lane contraflow to maximize the evacuation network capacity, and bus contraflow to realize the transit cycle operation. The application of this strategy takes two steps to provide transit priority during evacuation: solve the transit-based evacuation problem with a minimum-cost flow model, firstly, and then address the auto-based evacuation problem with a bilevel network flow model. The numerical results from optimizing an evacuation network for a super typhoon justify the validness and usefulness of the network aggregation method and the integrated contraflow strategy

Improving Scene Graph Generation with Superpixel-Based Interaction Learning

Recent advances in Scene Graph Generation (SGG) typically model the relationships among entities utilizing box-level features from pre-defined detectors. We argue that an overlooked problem in SGG is the coarse-grained interactions between boxes, which inadequately capture contextual semantics for relationship modeling, practically limiting the development of the field. In this paper, we take the initiative to explore and propose a generic paradigm termed Superpixel-based Interaction Learning (SIL) to remedy coarse-grained interactions at the box level. It allows us to model fine-grained interactions at the superpixel level in SGG. Specifically, (i) we treat a scene as a set of points and cluster them into superpixels representing sub-regions of the scene. (ii) We explore intra-entity and cross-entity interactions among the superpixels to enrich fine-grained interactions between entities at an earlier stage. Extensive experiments on two challenging benchmarks (Visual Genome and Open Image V6) prove that our SIL enables fine-grained interaction at the superpixel level above previous box-level methods, and significantly outperforms previous state-of-the-art methods across all metrics. More encouragingly, the proposed method can be applied to boost the performance of existing box-level approaches in a plug-and-play fashion. In particular, SIL brings an average improvement of 2.0% mR (even up to 3.4%) of baselines for the PredCls task on Visual Genome, which facilitates its integration into any existing box-level method

Feedback RoI Features Improve Aerial Object Detection

Neuroscience studies have shown that the human visual system utilizes high-level feedback information to guide lower-level perception, enabling adaptation to signals of different characteristics. In light of this, we propose Feedback multi-Level feature Extractor (Flex) to incorporate a similar mechanism for object detection. Flex refines feature selection based on image-wise and instance-level feedback information in response to image quality variation and classification uncertainty. Experimental results show that Flex offers consistent improvement to a range of existing SOTA methods on the challenging aerial object detection datasets including DOTA-v1.0, DOTA-v1.5, and HRSC2016. Although the design originates in aerial image detection, further experiments on MS COCO also reveal our module's efficacy in general detection models. Quantitative and qualitative analyses indicate that the improvements are closely related to image qualities, which match our motivation

An infectious clone of enterovirus 71(EV71) that is capable of infecting neonatal immune competent mice without adaptive mutations

Enterovirus 71 (EV71) is a major pathogen that causes hand, foot and mouth disease (HFMD), which is a life threatening disease in certain children. The pathogenesis of EV71-caused HFMD is poorly defined due to the lack of simple and robust animal models with severe phenotypes that recapitulate symptoms observed in humans. Here, we generated the infectious clone of a clinical isolate from a severe HFMD patient. Virus rescued from the cDNA clone was infectious in cell lines. When administrated intraperitoneally to neonatal ICR, BALB/c and C57 immune competent mice at a dosage of1.4 × 104 pfu per mouse, the virus caused weight loss, paralysis and death in the infected mice after 4-5 days of infection. In the infected mice, detectable viral replication was detected in various tissues such as heart, liver, brain, lung, kidney, small intestine, leg skeletal muscle and medulla oblongata. The histology of the infected mice included massive myolysis, glomerular atrophy, villous blunting in small intestine, widened alveolar septum, diminished alveolar spaces and lymphocytes infiltration into the lung. By using the UV-inactivated virus as a control, we elucidated that the virus first amplified in the leg skeletal muscle tissue and the muscle tissue served as a primary viral replication site. In summary, we generated a stable EV71 infectious clone that is capable of infecting neonatal immune competent mice without adaptive mutations and provide a simple, valuable animal model for the studies of EV71pathogenesis and therapy.</p

Deletion of FgHOG1 Is Suppressive to the mgv1 Mutant by Stimulating Gpmk1 Activation and Avoiding Intracellular Turgor Elevation in Fusarium graminearum

Fusarium head blight caused by Fusarium graminearum is an important disease of wheat and barley. Previous studies have showed that all three MAP kinase genes, MGV1, FgHOG1, and GPMK1, are involved in regulating hyphal growth, sexual reproduction, plant infection, and stress responses in this pathogen. To determine the relationship between the Mgv1 and FgHog1 pathways, in this study, we generated and characterized the mgv1 Fghog1 double mutant. Deletion of FgHOG1 partially rescued the defects of the mgv1 mutant in vegetative growth and cell wall integrity but had no effects on its defects in plant infection and DON production. The mgv1 Fghog1 mutant grew faster and was more tolerant to cell wall stressors than the mgv1 mutant. Swollen compartments and cell burst were observed frequently in the mgv1 mutant but rarely in the mgv1 Fghog1 mutant when treated with fungicide fludioxonil or cell wall stressor Congo red. Conversely, the deletion of MGV1 also alleviated the hyperosmotic sensitivity of the Fghog1 mutant in vegetative growth. TGY assays indicated increased phosphorylation of FgHog1 in the mgv1 mutant, and TEY assays further revealed elevated activation of Gpmk1 in the mgv1 Fghog1 double mutant, particularly under cell wall stress conditions. Overall, our data showed that deletion of FgHOG1 partially suppressed the defects of the mgv1 mutant, possibly by affecting genes related to cell wall integrity and osmoregulation via the over-activation of Gpmk1 MAP kinase and avoiding intracellular turgor elevation

GATA2 mutant variant allele frequency may reflect prognosis in Chinese adult patients with de novo cytogenetically normal acute myeloid leukemia

In this study, we analyzed GATA2 mutations (GATA2mut) and co-mutations in 166 Chinese patients with cytogenetically normal acute myeloid leukemia. This was done through targeted next-generation sequencing of 34 genes associated with myeloid leukemia. GATA2mut was identified in 17 (10%) patients being significantly correlated with co-mutations in CCAAT/enhancer-binding protein alpha (CEBPA) double mutation (P = 0.001). We observed that the N-terminal zinc finger domain (ZF1) was linked to CEBPA mutations, while the C-terminal zinc finger domain (ZF2) was associated with Wilms' tumor 1 (WT1) mutations. It was also noted that patients with GATA2mut had lower platelet counts at diagnosis (P = 0.032). In the entire cohort, GATA2mut had no significant prognostic impact on overall survival (OS) (P = 0.762) and relapse-free survival (RFS) (P = 0.369) compared to patients with GATA2wt. The OS (P = 0.737) and RFS (P = 0.894) of the ZF1 mutation were similar to those of the ZF2 mutation. Most patients with GATA2 mutations were classified in the ELN2022 favorable- and intermediate-risk groups. GATA2mut patients in the favorable-risk group were divided into GATA2High and GATA2Low groups using a median cutoff variant allele frequency (VAF) of 40.13%. GATA2High patients were associated with worse OS (P = 0.031) and RFS (P = 0.021) than GATA2Low patients. In the intermediate-risk group, the high median VAF of GATA2 (≥38.51%) had no significant effect in OS and RFS compared with the low median VAF (<38.51%). This study offers new insights on the prognosis of GATA2mut in the favorable-risk group, where VAF can be used as a guide