Additional file 2 of Establishment and validation of an immune infiltration predictive model for ovarian cancer

Additional file 2: Figure S2. Calibration plot at 1-, 3-, and 5-year of nomogram without IPM

Additional file 5 of Establishment and validation of an immune infiltration predictive model for ovarian cancer

Additional file 5: Table S1. Clinical information of TCGA-OV patients. Table S2. Immune-related genesets enriched in TP53 MUT OVs. Table S3. Differentially expressed immune-related genes between TP53 WT and TP53 MUT OVs.Table S4. Univariate Cox regression analysis of differentially expressed immune-related genes. Table S5. Analysis of correlations between risk score and immune checkpoints. Table S6. Top 20 clusters with their representative enriched terms by Metascape

Additional file 1 of Establishment and validation of an immune infiltration predictive model for ovarian cancer

Additional file 1: Figure S1. Correlatio between IPM and patient survival. (A) Status distribution in high- and low group. (B) Correlation between risk score and survival

Additional file 3 of Establishment and validation of an immune infiltration predictive model for ovarian cancer

Additional file 3: Figure S3. Distuibution of risk score in TP53 status

data sheet from Anti-inflammatory activity of electron-deficient organometallics

We report an evaluation of the cytotoxicity of a series of electron-deficient (16-electron) half-sandwich precious metal complexes of ruthenium, osmium and iridium ([Os/Ru(<i>η</i>⁶-<i>p</i>-cymene)(1,2-dicarba-<i>closo</i>-dodecarborane-1,2-dithiolato)] (<b>1/2</b>), [Ir(<i>η</i>⁵-pentamethylcyclopentadiene)(1,2-dicarba-<i>closo</i>-dodecarborane-1,2-dithiolato)] (<b>3</b>), [Os/Ru(<i>η</i>⁶-<i>p</i>-cymene)(benzene-1,2-dithiolato)] (<b>4/5</b>) and [Ir(<i>η</i>⁵-pentamethylcyclopentadiene)(benzene-1,2-dithiolato)] (<b>6</b>)) towards RAW 264.7 murine macrophages and MRC-5 fibroblast cells. Complexes <b>3</b> and <b>6</b> were found to be non-cytotoxic. The anti-inflammatory activity of <b>1–6</b> was evaluated in both cell lines after nitric oxide (NO) production and inflammation response induced by bacterial endotoxin lipopolysaccharide (LPS) as the stimulus. All metal complexes were shown to exhibit dose-dependent inhibitory effects on LPS-induced NO production on both cell lines. Remarkably, the two iridium complexes <b>3</b> and <b>6</b> trigger a full anti-inflammatory response against LPS-induced NO production, which opens up new avenues for the development of non-cytotoxic anti-inflammatory drug candidates with distinct structures and solution chemistry from that of organic drugs, and as such with potential novel mechanisms of action

Additional file 4 of Establishment and validation of an immune infiltration predictive model for ovarian cancer

Additional file 4: Figure S4. Nomogram for overall survival at 1-, 3-, and 5-year in ovarian cancer patients in IMvigor210 cohort

Environmental Polychlorinated Biphenyl Exposure and Breast Cancer Risk: A Meta-Analysis of Observational Studies

<div><p>Background</p><p>Association between polychlorinated biphenyl (PCB) exposure and breast cancer risk has been widely studied, but the results remain controversial. We performed a meta-analysis to evaluate the evidences from observational studies on PCB exposure and breast cancer risk.</p><p>Methods</p><p>Relevant studies with data on internal PCB dose were identified from PubMed, EMBASE, CBM and CNKI databases through November 2014. Multivariable-adjusted odds ratio (OR) with 95% confidence intervals (CIs) were applied to assess the association between PCB exposure and breast cancer risk. Heterogeneity test, sensitivity analysis, subgroup analysis and publication bias test were also performed. To further explore the association between specific groups of PCB congeners and breast cancer, we examined the PCB congeners classified, according to their structural, biological and pharmacokinetics properties, as group I (potentially estrogenic), group II (potentially anti-estrogenic and immunotoxic, dioxin-like), and group III (phenobarbital, CYP1A and CYP2B inducers, biologically persistent).</p><p>Results</p><p>Of 660 studies screened, 25 studies which met criteria were selected, involving a total of 12866 participants (6088 cases and 6778 controls) from eight countries. The results showed that the risk of breast cancer was associated with group II (OR = 1.23, 95% CI: 1.08–1.40) and group III (OR = 1.25, 95% CI: 1.09–1.43) PCBs, but not with group I (OR = 1.10, 95%CI: 0.97–1.24) PCBs or total PCB exposure (OR = 1.09, 95%CI: 0.97–1.22).</p><p>Conclusions</p><p>Our meta-analysis based on the selected studies found group II and group III PCB exposure might contribute to the risk of breast cancer. More studies in developing countries with higher PCB levels are needed, as well as studies to explore the relationships between mixtures of organochlorine compounds and breast cancer risk.</p></div

Additional file 1 of The efficacy and safety of tislelizumab combined with gemcitabine plus cisplatin in the treatment of postoperative patients with muscle-invasive upper tract urothelial carcinoma

Supplementary Material 1: STROBE Statement—checklist of items that should be included in reports of observational studie

Additional file 1: of Long-Term, Competitive Swimming and the Association with Atrial Fibrillation

Atrial fibrillation in endurance athletes study. (PDF 39 kb

Figures from Anti-inflammatory activity of electron-deficient organometallics

We report an evaluation of the cytotoxicity of a series of electron-deficient (16-electron) half-sandwich precious metal complexes of ruthenium, osmium and iridium ([Os/Ru(<i>η</i>⁶-<i>p</i>-cymene)(1,2-dicarba-<i>closo</i>-dodecarborane-1,2-dithiolato)] (<b>1/2</b>), [Ir(<i>η</i>⁵-pentamethylcyclopentadiene)(1,2-dicarba-<i>closo</i>-dodecarborane-1,2-dithiolato)] (<b>3</b>), [Os/Ru(<i>η</i>⁶-<i>p</i>-cymene)(benzene-1,2-dithiolato)] (<b>4/5</b>) and [Ir(<i>η</i>⁵-pentamethylcyclopentadiene)(benzene-1,2-dithiolato)] (<b>6</b>)) towards RAW 264.7 murine macrophages and MRC-5 fibroblast cells. Complexes <b>3</b> and <b>6</b> were found to be non-cytotoxic. The anti-inflammatory activity of <b>1–6</b> was evaluated in both cell lines after nitric oxide (NO) production and inflammation response induced by bacterial endotoxin lipopolysaccharide (LPS) as the stimulus. All metal complexes were shown to exhibit dose-dependent inhibitory effects on LPS-induced NO production on both cell lines. Remarkably, the two iridium complexes <b>3</b> and <b>6</b> trigger a full anti-inflammatory response against LPS-induced NO production, which opens up new avenues for the development of non-cytotoxic anti-inflammatory drug candidates with distinct structures and solution chemistry from that of organic drugs, and as such with potential novel mechanisms of action