Research on the Evolution Law Physical Short Fatigue Crack and Tip Deformation Fields during Crack Closure Process of the Q&P Steel

In this paper, a novel dual microscopic fatigue-crack and tip-deformation-fields measurement method based on a hybrid image-processing technique is proposed that was used to research the physical short fatigue crack (SFC) closure effect and the evolution law of the tip deformation fields of Quenching–Partitioning (Q&P) steel during the crack-closure process. The measurement problems are solved, such as the small SFC tip region, large deformation gradient, and strong material anisotropy. Microscopic crack and speckle images are acquired simultaneously on both sides of a compact tensile (CT) specimen of Q&P steel by dual microscopic cameras. A digital image processing (DIP) method is used to identify crack-growth morphology and measure crack length in Q&P steel, and the SFC growth rates are analyzed under different stress ratios. Microscopic digital image correlation (Micro-DIC) is used to analyze displacement fields at the crack tip of SFC and, combined with virtual extensometer technology, analyze the evolution law of crack closure and the evolution of crack-growing morphologies during the closure process under different lengths and stress ratios. Accordingly, the evolution of strain fields at the crack tip in one load cycle for different crack lengths and stress ratios during the SFC closure process is analyzed. The results show that the stress ratio affects the crack-closure behavior and crack growth rate of Q&P steel in the physical SFC crack-growing stage. The crack-closure effect has an obvious influence on the evolution process of displacement and strain fields at the crack tip. The evolution of short-fatigue-crack-tip morphology and strain field of Q&P steel conforms to the crack-closure law. The research results provide experimental and theoretical support for the further study of the SFC growth mechanism and fatigue life prediction of Q&P steel

In Situ Measurement of Cyclic Plastic Zone and Internal Strain Response of Q&P Steel near Fatigue Crack Tip Region Based on Micro-DIC

The shape and internal dynamic response characteristics of the plastic zone near the fatigue crack tip region, especially the cyclic plastic zone (CPZ), are the main factors affecting the fatigue crack initiation and propagation behaviors of ductile metal materials. The existing methods for characterizing the CPZ have some problems, which include the complexity of the process, the difficulty of achieving in situ measurement, and the inability to characterize the dynamic response in the CPZ during the crack propagation process. Therefore, a novel method is proposed for the in situ measurement of the CPZ near the crack tip region based on image stitching and matching algorithms, a load–strain loop curve characteristic judgement algorithm, and the microscopic digital image correlation (DIC) method. A microscopic camera and a macroscopic camera are used to simultaneously capture the micro crack tip speckle images and the global crack image of the two sides of the Compact Tension (CT) specimen for calculating in situ crack length and crack tip strain fields. The proposed method was performed and verified by a fatigue crack growth (FCG) test and micro-hardness experiments with Quenching and Partitioning 980 (Q&P980) steel, and the results show that the method is feasible because the maximum error is less than 5%. A “butterfly wings” shape of the CPZ and a strain concentration phenomenon in the CPZ of the Q&P980 were observed. Moreover, as the fatigue crack propagates, the area of the CPZ and the degree of the strain concentration increase gradually. This method, which can obtain the in situ and tracking measurements of the crack tip CPZ, will help to increase our understanding of CPZ characteristics, the FCG mechanism, and the behavior of Q&P steel and the plastic metal materials similar to Q&P steel

Structural Elucidation of a Polysaccharide from <i>Flammulina velutipes</i> and Its Lipid-Lowering and Immunomodulation Activities

FVPT1, a novel heteropolysaccharide, was purified from the fruiting body of Flammulina velutipes using magnetic-field-assisted three-phase partitioning and gel permeation chromatography. The structure was characterized using monosaccharide composition and methylation analysis, infrared spectroscopy and nuclear magnetic resonance (NMR). The FVPT1 (~1.64 × 104 Da) was composed of L-fucose, D-galactose, D-glucose and D-mannose at a molar ratio of 1.0:3.5:1.0:1.4. The polysaccharide repeating unit of FVPT1 was established with methylation analyses and NMR spectroscopy. Moreover, a zebrafish larva hyperlipidemia model test demonstrated that FVPT1 can show appreciable lipid-lowering effects. In addition, the FVPT1 exhibited remarkable immunoregulatory activity by increasing nitric oxide, interleukin (IL)-1β and IL-1 secretion in macrophages. Therefore, these results suggest that FVPT1 has the potential to be developed into a new immune or hypolipidemic health product

The efficacy of initial ventilation strategy for adult immunocompromised patients with severe acute hypoxemic respiratory failure: study protocol for a multicentre randomized controlled trial (VENIM)

Abstract Background Acute respiratory failure (ARF) is still one of the most severe complications in immunocompromised patients. Our previous systematic review showed noninvasive mechanical ventilation (NIV) reduced mortality, length of hospitalization and ICU stay in AIDS/hematological malignancy patients with relatively less severe ARF, compared to invasive mechanical ventilation (IMV). However, this systematic review was based on 13 observational studies and the quality of evidence was low to moderate. The efficacy of NIV in more severe ARF and in patients with other causes of immunodeficiency is still unclear. We aim to determine the efficacy of the initial ventilation strategy in managing ARF in immunocompromised patients stratified by different disease severity and causes of immunodeficiency, and explore predictors for failure of NIV. Methods and analysis The VENIM is a multicentre randomized controlled trial (RCT) comparing the effects of NIV compared with IMV in adult immunocompromised patients with severe hypoxemic ARF. Patients who meet the indications for both forms of ventilatory support will be included. Primary outcome will be 30-day all-cause mortality. Secondary outcomes will include in-hospital mortality, length of stay in hospital, improvement of oxygenation, nosocomial infections, seven-day organ failure, adverse events of intervention, et al. Subgroups with different disease severity and causes of immunodeficiency will also be analyzed. Discussion VENIM is the first randomized controlled trial aiming at assessing the efficacy of initial ventilation strategy in treating moderate and severe acute respiratory failure in immunocompromised patients. The result of this RCT may help doctors with their ventilation decisions. Trial registration ClinicalTrials.gov NCT02983851 . Registered 2 September 2016