Knowledge Domain and Emerging Trends on Echinococcosis Research: A Scientometric Analysis

The echinococcosis of humans and animals is a chronic helminthic disease caused by the larva of genus Echinococcus tapeworms. It is a globally distributed disease which is an important socioeconomic and public health problem in many low and middle-income countries. This research aimed to firstly quantitatively analyze the publications with bibliometrics software and evaluated the hot topics and emerging trends of echinococcosis research from 1980 to 2017. A total of 7688 references on echinococcosis research were retrieved from the Web of Science Core Collection database. Then the reference was analyzed with CiteSpace software to make the knowledge network maps. The largest cluster (#0) with 83 members was cystic echinococcosis, and cystic echinococcosis, mebendazole, antibody and transmission were the four keywords with the strongest citation bursts in the echinococcosis research field. Furthermore, cystic echinococcosis, chemotherapy and immunodiagnosis, management of definitive and intermediate host are the top four research hot topics and emerging trends in the echinococcosis field. This research presents an insight into the echinococcosis field and valuable visualizing information for echinococcosis researchers to detect new viewpoints on cooperative countries/institutions, potential co-workers and research frontiers

Multiple dynamic Al-based floc layers on ultrafiltration membrane surfaces for humic acid and reservoir water fouling reduction

The integration of adsorbents with ultrafiltration (UF) membranes is a promising method for alleviating membrane fouling and reducing land use. However, adsorbents typically are only injected into the membrane tank once, resulting in a single dynamic protection layer and low removal efficiency over long-term operation. In addition, the granular adsorbents used can cause membrane surface damage. To overcome these disadvantages, we injected inexpensive and loose aluminum (Al)-based flocs directly into a membrane tank with bottom aeration in the presence of humic acid (HA) or raw water taken from the Miyun Reservoir (Beijing, China). Results showed that the flocs were well suspended in the membrane tank, and multiple dynamic floc protection layers were formed (sandwich-like) on the membrane surface with multiple batch injections. Higher frequency floc injections resulted in better floc utilization efficiency and less severe membrane fouling. With continuous injection, acid solutions demonstrated better performance in removing HA molecules, especially those with small molecular weight, and in alleviating membrane fouling compared with the use of high aeration rate or polyacrylamide injection. This was attributed to the small particle size, large specific surface area, and high zeta potential of the flocs. Additionally, excellent UF membrane performance was exhibited by reservoir water with continuous injection and acid solution. Based on the outstanding UF membrane performance, this innovative integrated filtration with loose Al-based flocs has great application potential for water treatment

A Trial and Perceptions Assessment of APP-Based Flipped Classroom Teaching Model for Medical Students in Learning Immunology in China

The application-based flipped classroom (APP-FC) is an innovative teaching-learning model that has not been applied and assessed in basic medical curricula teaching in China. The aim of this investigation is to assess students’ perceptions to the APP-based flipped classroom (APP-FC) teaching model in an immunology course. The data of this study were collected from second-year medical students (n = 92) at Lanzhou University. One class (n = 50), as a control group, was offered lecture-based learning (LBL), while the other class (n = 42), as the APP-FC group, was given lecture-based instruction and the APP-FC teaching model during September–November 2017. Afterward, the perceptions of students on APP-FC teaching model were evaluated using questionnaires. Students responded that APP-FC improves their motivation (83%) and interest in learning immunology (81%), as well as their self-directed learning skills (81%). Compared to the traditional lecture-based instruction, the APP-FC noticeably improved students’ motivation in learning (P = 0.011), self-directed learn skills (P = 0.001), memory abilities (P = 0.009), and problem-solving abilities (P = 0.010). Most medical students’ scores (60%) in the final examination were more than 80 points after implementing an APP-FC model as compared to the control group (40%). The majority of students (70%) preferred the APP-FC teaching approach over traditional lecture-based pedagogy. The implementation of the APP-FC teaching model could improve students’ learning motivation, self-directed learn skills, and problem-solving abilities, which is a preferable teaching model for medical immunology courses in China

B: Circulating microRNAs as potential biomarkers for smokingrelated interstitial fibrosis. Biomarkers 2012, 17(5):435–440.Submit your manuscript at www.biomedcentral.com/submit

Abstract Numerous efforts have been made to indentify reliable and predictive biomarkers to detect the early signs of smokinginduced lung disease. Using 6-month cigarette smoking in mice, we have established smoking-related interstitial fibrosis (SRIF). Microarray analyses and cytokine/chemokine biomarker measurements were made to select circulating microRNAs (miRNAs) biomarkers. We have demonstrated that specific miRNAs species (miR-125b-5p, miR-128, miR30e, and miR-20b) were significantly changed, both in the lung tissue and in plasma, and exhibited mainstream (MS) exposure duration-dependent pathological changes in the lung. These findings suggested a potential use of specific circulating miRNAs as sensitive and informative biomarkers for smoking-induced lung disease

Correlations between weight-for-length Z-scores and fecal calprotectin concentrations.

<p>Correlations between weight-for-length Z-scores and fecal calprotectin concentrations.</p

Correlations between weight-for-age Z-scores and fecal calprotectin concentrations.

<p>Correlations between weight-for-age Z-scores and fecal calprotectin concentrations.</p

The Effect of Iron Fortification on Iron (Fe) Status and Inflammation: A Randomized Controlled Trial

<div><p>Background</p><p>Iron deficiency (ID) is common in toddlers in developing countries. Iron fortified or meat-based complementary foods may be effective to prevent ID.</p><p>Objective</p><p>Our objective was to compare iron status at 18 months and growth from 6 to 18 months in rural poor toddlers fed 3 different complementary foods.</p><p>Methods</p><p>The study was nested within a larger trial in which 6-month-old infants were randomized to receive 50g/d meat (MG), an equi-caloric fortified cereal supplement (FG) or local cereal supplement (LG) for 1 year. Hb, sTfR, HsCRP, ferritin and AGP were measured in 410 blood samples collected by a random sampling (MG, 137; FG, 140; LG, 133); calprotectin was measured in feces. Body iron = -[log (sTfR ×1000/ferritin)-2.8229] /0.1207. ID = ferritin<12ug/L.</p><p>Results</p><p>The toddlers in FG had the significantly highest levels in serum ferritin and body iron (<i>P</i> = 0.043, 0.004), and the rates of both ID and iron deficiency anemia (IDA) were the lowest in FG (<i>P</i> = 0.010, 0.021). The rate of systemic inflammation in FG was 30.71%, which was the highest among three groups (<i>P</i> = 0.042). No intervention effects on either the rates of ID and IDA or iron stores (serum ferritin and body iron) were shown in MG. The change in length-for-age z scores (LAZ) from 6 to 18 months among three groups was significantly different (<i>P</i> = 0.021) and a smaller decrease of LAZ in MG and a larger decrease of LAZ in FG were observed.</p><p>Conclusion</p><p>Iron fortified cereal improved iron status of poor rural toddlers but was also associated with systemic inflammation which was likely to impair their growth.</p></div

Fecal calprotectin concentrations, LAZ, WAZ and WLZ in apparently healthy children.

<p>Fecal calprotectin concentrations, LAZ, WAZ and WLZ in apparently healthy children.</p