MOESM2 of Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review

Additional file 2: Table S2. Assessment of prognostic biomarker studies for risk of bias using the “Quality Assessment in Prognostic studies” (QUIPS) tool

Quantitative Assessment of Common Genetic Variants on <i>FOXE1</i> and Differentiated Thyroid Cancer Risk

<div><p>Forkhead box E1 encodes the transcription factor FOXE1 (or TTF-2), which together with Homeobox protein NKX2-1, PAX8 and HHEX, are pivotal proteins required for thyroid gland formation, differentiation and function. Recently, genome-wide association studies have identified <i>FOXE1</i> as a thyroid cancer (TC) susceptibility gene in populations of European descent. After that, a number of studies reported that the rs965513, rs1867277, and rs71369530 polymorphism in <i>FOXE1</i> has been implicated in TC risk. However, the causal variants remain unknown. To derive a more precise estimation of the relationship, a meta-analysis of 9,828 TC cases and 109,995 controls from 14 case–control studies was performed. Overall, significant results were observed for rs965513 (OR = 1.71, 95% CI: 1.59–1.85, P<10⁻⁵), rs1867277 (OR = 1.64, 95% CI: 1.51–1.78, P<10⁻⁵) and rs71369530 (OR = 2.01, 95% CI: 1.66–2.44, P<10⁻⁵) polymorphism. In the subgroup analysis by ethnicity, we found that rs965513 polymorphism confer high risk for Caucasians with per-allele OR of 1.80 (95% CI: 1.69–1.92, P<10⁻⁵) compared to East Asians of 1.35 (95% CI: 1.09–1.67, P = 0.006). There was strong evidence of heterogeneity, which largely disappeared after stratification by ethnicity. In the subgroup analysis by sample size, and study design, significantly increased risks were found for the polymorphism. In conclusion, this meta-analysis demonstrated that common variations of <i>FOXE1</i> are a risk factor associated with increased TC susceptibility.</p></div

MOESM1 of Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review

Additional file 1: Table S1. Description of original studies included in the systematic review

Main results of overall and subgroups in the meta-analysis.

a<p>Cochran's chi-square Q statistic test used to assess the heterogeneity in subgroups.</p>b<p>Cochran's chi-square Q statistic test used to assess the heterogeneity between subgroups.</p

Common Variants on Cytotoxic T Lymphocyte Antigen-4 Polymorphisms Contributes to Type 1 Diabetes Susceptibility: Evidence Based on 58 Studies

<div><p>In the past decade, a number of case–control studies have been carried out to investigate the relationship between the <i>CTLA4</i> gene polymorphisms and type 1 diabetes (T1D). However, these studies have yielded contradictory results. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the relationship between the <i>CTLA4</i> polymorphism and T1D. In total, 58 association studies on two <i>CTLA4</i> polymorphisms (G49A and C60T) and risk of T1D, including a total of 30,723 T1D cases and 45,254 controls were included. In a combined analysis, the summary per-allele odds ratio (OR) for T1D of the G49A and C60T polymorphism was 1.42 [95% confidence interval (CI): 1.31–1.53, P<10⁻⁵] and 1.23 (95% CI: 1.18–1.29, P<10⁻⁵), respectively. Significant results were also observed using dominant or recessive genetic model. In the subgroup analysis by ethnicity and sample size, significantly increased risks were also found for these polymorphisms. This meta-analysis demonstrated that the G49A and C60T polymorphism of <i>CTLA4</i> is a risk factor associated with increased T1D susceptibility, but these associations vary in different ethnic populations.</p></div

Characteristics of the studies included in the meta-analysis.

<p>NA: Not Available, WHO: World Health Organization, ADA: American Diabetes Association, ECDC: Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, IS-PAD: International Society of Paediatric and Adolescent Diabetes.</p

Meta-analysis of the <i>CTLA-4</i> C60T polymorphism on type 1 diabetes risk.

<p>NA: not available.</p

Forest plot from the meta-analysis of type 1 diabetes risk and <i>CTLA4</i> C60T polymorphism.

<p>Forest plot from the meta-analysis of type 1 diabetes risk and <i>CTLA4</i> C60T polymorphism.</p