1 research outputs found
Physical Separation of Enantiomeric Products by Compartmentalized Parallel Kinetic Resolution
Accessing
each enantiomer of a chiral molecule starting from a
racemic mixture remains a daunting challenge in chemistry. Indeed,
until now, only a few solutions exist to separate enantiomers of an
equimolar mixture of a chiral precursor. In this study, we establish
a new strategy to prepare simultaneously and physically separate both
enantioenriched enantiomers of a molecule starting from a racemic
substrate. This process combines two enantiomeric catalytic systems,
working in parallel, and separation by an achiral membrane with selective
permeability. This unprecedented system was successfully applied to
the simultaneous preparation of both enantiomers of chiral 1,2-diols
starting from racemic epoxides using Jacobsenās hydrolytic
kinetic resolution (HKR) in parallel