Thermally Induced [3 + 2] Cycloaddition of Alkynyl-Tethered Diazoamides: Synthetic and Mechanistic Insights

A general and unprecedented thermally induced formal [3 + 2] cycloaddition has been developed that provides a general access to fused lactam derivatives in high to excellent yields with broad substrate scope. In comparison with the reported metal-catalyzed carbene/alkynyl metathesis, this is the only example in this area under catalyst-free conditions with excellent selectivity. Mechanistic studies indicate that the 3<i>H</i>-pyrazole is the key intermediate in this cascade reaction, which is confirmed spectroscopically for the first time

Thermally Induced [3 + 2] Cycloaddition of Alkynyl-Tethered Diazoamides: Synthetic and Mechanistic Insights

A general and unprecedented thermally induced formal [3 + 2] cycloaddition has been developed that provides a general access to fused lactam derivatives in high to excellent yields with broad substrate scope. In comparison with the reported metal-catalyzed carbene/alkynyl metathesis, this is the only example in this area under catalyst-free conditions with excellent selectivity. Mechanistic studies indicate that the 3<i>H</i>-pyrazole is the key intermediate in this cascade reaction, which is confirmed spectroscopically for the first time

Forest plot meta-analyses of studies evaluating the sensitivity of live stiffness measured by TE to predict the overall postoperative complications.

<p>Forest plot meta-analyses of studies evaluating the sensitivity of live stiffness measured by TE to predict the overall postoperative complications.</p

Effect of individual studies on the pooled ORs of the prognostic value of liver stiffness measurement for overall postoperative complications.

<p>Effect of individual studies on the pooled ORs of the prognostic value of liver stiffness measurement for overall postoperative complications.</p

Thermally Induced [3 + 2] Cycloaddition of Alkynyl-Tethered Diazoamides: Synthetic and Mechanistic Insights

A general and unprecedented thermally induced formal [3 + 2] cycloaddition has been developed that provides a general access to fused lactam derivatives in high to excellent yields with broad substrate scope. In comparison with the reported metal-catalyzed carbene/alkynyl metathesis, this is the only example in this area under catalyst-free conditions with excellent selectivity. Mechanistic studies indicate that the 3<i>H</i>-pyrazole is the key intermediate in this cascade reaction, which is confirmed spectroscopically for the first time

Diagnostic data of each studies evaluating the performance of TE for postoperative complications.

<p>Diagnostic data of each studies evaluating the performance of TE for postoperative complications.</p

SROC curves for 6 studies of live stiffness measured by TE to predict the overall postoperative complications.

<p>SROC curves for 6 studies of live stiffness measured by TE to predict the overall postoperative complications.</p

The fundamental features of the included studies.

<p>The fundamental features of the included studies.</p

Forest plot meta-analyses of studies evaluating the specificity of live stiffness measured by TE to predict the overall postoperative complications.

<p>Forest plot meta-analyses of studies evaluating the specificity of live stiffness measured by TE to predict the overall postoperative complications.</p

Subgroup analyses for association between LSM and overall postoperative complications.

<p>Subgroup analyses for association between LSM and overall postoperative complications.</p