Role of Side Effects, Physician Involvement, and Patient Perception in Non-Adherence with Oral Bisphosphonates

<p><b>Article full text</b></p> <p><br></p> <p>The full text of this article can be found here<b>. </b><a href="https://link.springer.com/article/10.1007/s12325-016-0360-3">https://link.springer.com/article/10.1007/s12325-016-0360-3</a></p><p></p> <p><br></p> <p><b>Provide enhanced content for this article</b></p> <p><br></p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p><br></p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p><br></p> <p>Other enhanced features include, but are not limited to:</p> <p><br></p> <p>• Slide decks</p> <p>• Videos and animations</p> <p>• Audio abstracts</p> <p>• Audio slides</p

Additional file 1: of Cytoreductive treatment patterns among US veterans with polycythemia vera

Table S1. Thrombotic and Cardiovascular Event Codes. This table presents the ICD-9-CM codes for thrombotic and cardiovascular events employed in the study. (PDF 61 kb

Additional file 2: of Impact of Myeloproliferative neoplasms on patients’ employment status and work productivity in the United States: results from the living with MPNs survey

Table S2. Correlation Between WPAI-SHP Scores and MPN-SAF Symptom Scores. (DOCX 54 kb

Additional file 1: of Impact of Myeloproliferative neoplasms on patients’ employment status and work productivity in the United States: results from the living with MPNs survey

Table S1. Survey Questions Reported in This Analysis. (DOCX 55 kb

High-Throughput Metabolomics for Discovering Potential Metabolite Biomarkers and Metabolic Mechanism from the APPswe/PS1dE9 Transgenic Model of Alzheimer’s Disease

Alzheimer’s disease (AD), a neurodegenerative disorder, is the major form of dementia. As AD is an irreversible disease, it is necessary to focus on earlier intervention. However, the potential biomarkers of preclinical AD are still not clear. In this study, urinary metabolomics based on ultra-high-performance liquid chromatography coupled with quadruple time-of-flight mass spectrometry was performed for delineating the metabolic changes and potential early biomarkers in APPswe/PS1dE9 (APP/PS1) transgenic mice. A total of 24 differentially regulated metabolites were identified when comparing transgenic mice to wild-type mice using multivariate statistical analysis. Among them, 10 metabolites were significantly upregulated and 14 metabolites were downregulated. On the basis of these potential biomarkers, metabolic pathway analysis found that pentose and glucuronate interconversions, glyoxylate and dicarboxylate metabolism, starch and sucrose metabolism, the citrate cycle, tryptophan metabolism, and arginine and proline metabolism were disturbed in APP/PS1 mice. Our study revealed that levels of endogenous metabolites in the urine of APP/PS1 mice changed prior to the emergence of learning and cognitive impairment, which may be associated with abnormal nitric oxide production pathways and metabolic disorders of monoaminergic neurotransmitters. In conclusion, this study showed that metabolomics provides an early indicator of disease occurrence for AD

Comparison of the different SNP modes in two loci between cases and controls.

<p>Comparison of the different SNP modes in two loci between cases and controls.</p

Comparison of ABCB1 methylation levels between cases and controls.

<p>Comparison of ABCB1 methylation levels between cases and controls.</p

Subgroup analysis for SNP in rs1045642 and rs1128503 between cases and controls.

<p>Subgroup analysis for SNP in rs1045642 and rs1128503 between cases and controls.</p

Comparison of clinical events and genotypes in rs1045642 and rs1128503.

<p>Comparison of clinical events and genotypes in rs1045642 and rs1128503.</p

The primers for SNP genotyping and DNA methylation assay.

<p>The primers for SNP genotyping and DNA methylation assay.</p