2,257 research outputs found
Effects of the Aidi Dripping Pills on Immune Functions of the Tumor-bearing Mouse
ObjectiveTo study the effects of Aidi Dripping Pills on immune functions of the tumor-bearing mouse on the basis of the previous experimental studies on its tumor-inhibiting and life-prolonging effects.MethodsBy using the transplantation tumor mouse models, the effects of Aidi Dripping Pills on the lymphocyte transformation rate and the hemolysin formation in the S180 tumor-bearing mice, and on the phagocytic function of macrophages in the abdominal cavity of H22 tumor-bearing mice were investigated.ResultsIn the 2.25 g/kg and 1.125 g/kg Aidi Dripping Pills groups, the lymphocyte transformation rates in the S180 tumor-bearing mice were significantly higher than that of the control group (P<0.01). In all the Aidi Dripping Pills groups, HC50 significantly increased (P<0.01 or P<0.05), carbon granular clearance significantly raised, and both the phagocytic index and phagocytic coefficient were significantly higher than those in the control group (P<0.01 or P<0.05).ConclusionThe Aidi Dripping Pills can significantly increase the cellular immune function, the humoral immune function and the phagocytic function of the mononuclear-macrophages, so it may show anti-tumor effects by enhancing the function of the reticuloendothelial system
Plasma level of M-CSF was independently related to 30-day survival in patients with suspected sepsis, and correlated to pathogen load: A prospective cohort study.
The purpose of our study was to screen the plasma cytokines to find possible indicators of disease progression and prognosis of patients with infection. With a prospective cohort study, selected patients were divided into sepsis group and non-sepsis group. Demographic and clinical information were collected. Blood samples were tested for the levels of plasma cytokines and metagenomic next-generation sequencing (mNGS). 30-day follow-up information was recorded, and data was analyzed by SPSS22.0 (SPSS Inc, Chicago, IL). A total of 95 patients were selected. After propensity score matching of age and gender, 36 patients with sepsis and 36 with non-sepsis were enrolled. 30-day follow-up data exhibited that 41 patients died and 31 survived. Patients with sepsis and 30-day death had higher plasma levels of cytokines, including macrophage-stimulating factor (M-CSF), monocyte chemoattractant protein-3 (MCP-3), etc., than patients with non-sepsis and 30-day survival, respectively. M-CSF > 8.21pg/ml was an independent risk factor for 30-day death, and the reads of pathogens in mNGS reports was positively correlated with the plasma concentrations of various cytokines, including M-CSF
Genome-wide TCP transcription factors analysis provides insight into their new functions in seasonal and diurnal growth rhythm in Pinus tabuliformis
Background Pinus tabuliformis adapts to cold climate with dry winter in northern China, serving as important commercial tree species. The TEOSINTE BRANCHED 1, CYCLOIDEA, and PROLIFERATING CELL FACTOR family(TCP)transcription factors were found to play a role in the circadian clock system in Arabidopsis. However, the role of TCP transcription factors in P. tabuliformis remains little understood. Results In the present study, 43 TCP genes were identified from P. tabuliformis genome database. Based on the phylogeny tree and sequence similarity, the 43 TCP genes were classified into four groups. The motif results showed that different subfamilies indeed contained different motifs. Clade II genes contain motif 1, clade I genes contain motif 1, 8, 10 and clade III and IV contain more motifs, which is consistent with our grouping results. The structural analysis of PtTCP genes showed that most PtTCPs lacked introns. The distribution of clade I and clade II on the chromosome is relatively scattered, while clade III and clade IV is relatively concentrated. Co-expression network indicated that PtTCP2, PtTCP12, PtTCP36, PtTCP37, PtTCP38, PtTCP41 and PtTCP43 were co-expressed with clock genes in annual cycle and their annual cycle expression profiles both showed obvious seasonal oscillations. PtTCP2, PtTCP12, PtTCP37, PtTCP38, PtTCP40, PtTCP41, PtTCP42 and PtTCP43 were co-expressed with clock genes in diurnal cycle. Only the expression of PtTCP42 showed diurnal oscillation. Conclusions The TCP gene family, especially clade II, may play an important role in the regulation of the season and circadian rhythm of P. tabuliformis. In addition, the low temperature in winter may affect the diurnal oscillations
Reconfigurable nanoelectronics using graphene based spintronic logic gates
This paper presents a novel design concept for spintronic nanoelectronics
that emphasizes a seamless integration of spin-based memory and logic circuits.
The building blocks are magneto-logic gates based on a hybrid
graphene/ferromagnet material system. We use network search engines as a
technology demonstration vehicle and present a spin-based circuit design with
smaller area, faster speed, and lower energy consumption than the
state-of-the-art CMOS counterparts. This design can also be applied in
applications such as data compression, coding and image recognition. In the
proposed scheme, over 100 spin-based logic operations are carried out before
any need for a spin-charge conversion. Consequently, supporting CMOS
electronics requires little power consumption. The spintronic-CMOS integrated
system can be implemented on a single 3-D chip. These nonvolatile logic
circuits hold potential for a paradigm shift in computing applications.Comment: 14 pages (single column), 6 figure
Quantum parametric amplifiation of phonon-mediated magnon-spin interaction
The recently developed hybrid magnonics provides new opportunities for
advances in both the study of magnetism and the development of quantum
information processing. However, engineering coherent quantum state transfer
between magnons and specific information carriers, in particular, mechanical
oscillators and solid-state spins, remains challenging due to the intrinsically
weak interactions and the frequency mismatch between diffrent components. Here,
we show how to strongly couple the magnon modes in a nanomagnet to the
quantized mechanical motion (phonons) of a micromechanical cantilever in a
hybrid tripartite system. The coherent and enhanced magnon-phonon coupling is
engineered by introducing the quantum parametric amplifiation of the mechanical
motion. With experimentally feasible parameters, we show that the mechanical
parametric drive can be adjusted to drive the system into the strong-coupling
regime and even the ultrastrong-coupling regime. Furthermore, we show the
coherent state transfer between the nanomagnet and a nitrogen-vacancy center in
the dispersive-coupling regime, with the magnon-spin interaction mediated by
the virtually-excited squeezed phonons. The amplifid mechanical noise can
hardly interrupt the coherent dynamics of the system even for low mechanical
quality factors, which removes the requirement of applying additional
engineered-reservoir techniques. Our work opens up prospects for developing
novel quantum transducers, quantum memories and high-precision measurements.Comment: 14 pages, 4 figure
Tetraaqua(nitrato-κ2 O,O′)bis(pyridinium-4-carboxylate-κO)europium(III) dinitrate
The asymmetric unit of the title compound, [Eu(NO3)(C6H5NO2)2(H2O)4](NO3)2, consists of one-half of the C
2 symmetric coordination cation and one nitrate anion. The eight-coordinated EuIII atom is in a distorted dodecahedral coordination environment. The coordination cations and nitrate anions are connected via O—H⋯O and N—H⋯O hydrogen bonds into a three-dimensional network
Data Processing Pipeline for Pointing Observations of Lunar-based Ultraviolet Telescope
We describe the data processing pipeline developed to reduce the pointing
observation data of Lunar-based Ultraviolet Telescope (LUT), which belongs to
the Chang'e-3 mission of the Chinese Lunar Exploration Program. The pointing
observation program of LUT is dedicated to monitor variable objects in a
near-ultraviolet (245-345 nm) band. LUT works in lunar daytime for sufficient
power supply, so some special data processing strategies have been developed
for the pipeline. The procedures of the pipeline include stray light removing,
astrometry, flat fielding employing superflat technique, source extraction and
cosmic rays rejection, aperture and PSF photometry, aperture correction, and
catalogues archiving, etc. It has been intensively tested and works smoothly
with observation data. The photometric accuracy is typically ~0.02 mag for LUT
10 mag stars (30 s exposure), with errors come from background noises,
residuals of stray light removing, and flat fielding related errors. The
accuracy degrades to be ~0.2 mag for stars of 13.5 mag which is the 5{\sigma}
detection limit of LUT.Comment: 10 pages, 7 figures, 4 tables. Minor changes and some expounding
words added. Version accepted for publication in Astrophysics and Space
Science (Ap&SS
Dialogue State Distillation Network with Inter-Slot Contrastive Learning for Dialogue State Tracking
In task-oriented dialogue systems, Dialogue State Tracking (DST) aims to
extract users' intentions from the dialogue history. Currently, most existing
approaches suffer from error propagation and are unable to dynamically select
relevant information when utilizing previous dialogue states. Moreover, the
relations between the updates of different slots provide vital clues for DST.
However, the existing approaches rely only on predefined graphs to indirectly
capture the relations. In this paper, we propose a Dialogue State Distillation
Network (DSDN) to utilize relevant information of previous dialogue states and
migrate the gap of utilization between training and testing. Thus, it can
dynamically exploit previous dialogue states and avoid introducing error
propagation simultaneously. Further, we propose an inter-slot contrastive
learning loss to effectively capture the slot co-update relations from dialogue
context. Experiments are conducted on the widely used MultiWOZ 2.0 and MultiWOZ
2.1 datasets. The experimental results show that our proposed model achieves
the state-of-the-art performance for DST.Comment: Accepted by AAAI 202
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