Self-Adjustable Crystalline Inorganic Nanocoils

Biomacromolecules such as proteins, although extremely complex in microstructure, can crystallize into macro-sized crystals after self-adjusting their shapes, based on which the structure of biology is built. Inorganic nanowires/nanoribbons with a similar one-dimensional topology but much simpler structures can hardly be as flexible as macromolecules when constructing superlattice structures because of their inherent rigidity. Here we report the synthesis of crystalline indium sulfide nanoribbon-based nanocoils that are formed by spontaneous self-coiling of ultrathin nanoribbons. The nanostructures are flexible and appear as relatively random coils because of their ultrathin ribbon structures (∼0.9 nm in thickness) with high aspect ratios. Moreover, the nanocoils can self-adjust their shapes and assemble into two-dimensional superlattices and three-dimensional supercrystals in solution. The ultrathin nanocoils are expected to bring new insights into the use of flexible nanocrystals as building blocks for constructing superstructures

Hierarchical MnO₂/SnO₂ Heterostructures for a Novel Free-Standing Ternary Thermite Membrane

We report the synthesis of a novel hierarchical MnO₂/SnO₂ heterostructures via a hydrothermal method. Secondary SnO₂ nanostructure grows epitaxially on the surface of MnO₂ backbones without any surfactant, which relies on the minimization of surface energy and interfacial lattice mismatch. Detailed investigations reveal that the cover density and morphology of the SnO₂ nanostructure can be tailored by changing the experimental parameter. Moreover, we demonstrate a bottom-up method to produce energetic nanocomposites by assembling nanoaluminum (n-Al) and MnO₂/SnO₂ hierarchical nanostructures into a free-standing MnO₂/SnO₂/n-Al ternary thermite membrane. This assembled approach can significantly reduce diffusion distances and increase their intimacy between the components. Different thermite mixtures were investigated to evaluate the corresponding activation energies using DSC techniques. The energy performance of the ternary thermite membrane can be manipulated through different components of the MnO₂/SnO₂ heterostructures. Overall, our work may open a new route for new energetic materials

(Ni,Mg)₃Si₂O₅(OH)₄ Solid-Solution Nanotubes Supported by Sub-0.06 wt % Palladium as a Robust High-Efficiency Catalyst for Suzuki–Miyaura Cross-Coupling Reactions

(Ni_1–<i>x</i>,Mg_<i>x</i>)₃Si₂O₅(OH)₄ solid-solution nanotubes (NTs) with tunable compositions were hydrothermally synthesized by altering the molar ratio of Mg²⁺ to Ni²⁺. The as-synthesized NTs were loaded with sub-0.06 wt % palladium (Pd; ∼0.045 wt %) for Suzuki–Miyaura (SM) coupling reactions between iodobenzene or 4-iodotoluene and phenylboronic acid. The (Ni,Mg)₃Si₂O₅(OH)₄ (Mg²⁺:Ni²⁺ = 1.0:1.0) NTs supported by 0.045 wt % Pd promoted the iodobenzene-participated coupling reaction with a high yield of >99%, an excellent recycling catalytic performance during 10 cycles of catalysis with yields of ∼99%, and also an extremely low Pd releasing level of ∼0.02 ppm. High-activity Pd and PdO clusters, multitudes of dislocations, and defects and terraces contained within the NTs should contribute to the (Ni,Mg)₃Si₂O₅(OH)₄ (Mg²⁺:Ni²⁺ = 1.0:1.0) NTs supported by 0.045 wt % Pd as a robust, reusable, and high-efficiency catalyst for SM coupling reactions with an extremely low Pd releasing level. The present hydrothermally stable (Ni,Mg)₃Si₂O₅(OH)₄ (Mg²⁺:Ni²⁺ = 1.0:1.0) solid-solution silicate NTs provided an ideal alternative tubular-structured support for noble- or transition-metal catalysts with low Pd loading, good recycling, and extremely low ppb levels of Pd release, which could also be extended to some other SM coupling reactions

Glycine-Mediated Syntheses of Pt Concave Nanocubes with High-Index {<i>hk</i>0} Facets and Their Enhanced Electrocatalytic Activities

Metal nanocrystals with high-index facets (HIFs) have drawn significant attention for their superior catalysis activity compared to that of low-index faces. However, because of the high surface energy of HIFs, it is still challenging to preserve HIFs during the growth of nanocrystals. In this study, highly selective Pt concave nanocubes (CNCs) with high-index {<i>hk</i>0} facets have been successfully prepared in a simple aqueous solution. The vital role of glycine as the surface controller in the formation of CNCs was demonstrated. These Pt CNCs exhibited enhanced specific activities toward the electro-oxidation of methanol and formic acid in comparison to commercial Pt black and Pt/C catalysts

Comparison of actual nutrient intake between PCOS and control participants.

<p>¹ IQR, interquartile range</p><p>* <i>P</i> < 0.05</p><p>^※ Mann-Whitney U test</p><p>Comparison of actual nutrient intake between PCOS and control participants.</p

Top 20 food items consumed by participants for supplying fat, carbohydrate and protein.

<p>Top 20 food items consumed by participants for supplying fat, carbohydrate and protein.</p

Hormonal and metabolic results of PCOS and control participants.

<p>¹ PCOS, polycystic ovary syndrome;</p><p>² FT, free testosterone;</p><p>³ T, testosterone;</p><p>⁴ E₂, estradiol;</p><p>⁵ LH, luteinizing hormone;</p><p>⁶ FSH, follicle stimulating hormone;</p><p>⁷ FINS, fasting insulin;</p><p>⁸ FPG, fasting plasma glucose;</p><p>* <i>P</i> < 0.05</p><p>^# Student’s t-test</p><p>Hormonal and metabolic results of PCOS and control participants.</p

Data_Sheet_1_Case report: Genotype-phenotype characteristics of nine novel PKD1 mutations in eight Chinese patients with autosomal dominant polycystic kidney disease.pdf

IntroductionAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder. The PKD1 gene is responsible for the majority of ADPKD cases, and the mutations in this gene exhibit high genetic diversity. This study aimed to investigate the association between genotype and phenotype in ADPKD patients with PKD1 gene mutations through pedigree analysis.MethodsEight Chinese pedigrees affected by ADPKD were analyzed using whole-exome sequencing (WES) on peripheral blood DNA. The identified variants were validated using Sanger sequencing, and clinical data from the patients and their families were collected and analyzed.ResultsNine novel mutation sites in PKD1 were discovered across the pedigrees, including c.4247T > G, c.3298_3301delGAGT, c.4798A > G, c.7567G > A, c.11717G > C, c.7703 + 5G > C, c.3296G > A, c.8515_8516insG, and c.5524C > A. These mutations were found to be associated with a range of clinical phenotypes, including chronic kidney disease, hypertension, and polycystic liver. The age of onset and disease progression displayed significant heterogeneity among the pedigrees, with some individuals exhibiting early onset and rapid disease progression, while others remained asymptomatic or had milder disease symptoms. Inheritance patterns supported autosomal dominant inheritance, as affected individuals inherited the mutations from affected parents. However, there were instances of individuals carrying the mutations who remained asymptomatic or exhibited milder disease phenotypes.ConclusionThis study highlights the importance of comprehensive genotype analysis in understanding the progression and prognosis of ADPKD. The identification of novel mutation sites expands our knowledge of PKD1 gene mutations. These findings contribute to a better understanding of the disease and may have implications for personalized therapeutic strategies.</p

The clinical characteristics between PCOS and control participants.

<p>¹ PCOS, polycystic ovary syndrome;</p><p>² PCO, polycystic ovary;</p><p>³ BMI, body mass index;</p><p>⁴ WHR, waist hip ratio;</p><p>⁵ IR, insulin resistance;</p><p>* <i>P</i><0.05</p><p>^<i>#</i> Chi-square test</p><p>The clinical characteristics between PCOS and control participants.</p

The morphology of the BMSCs after co-culturing.

<p>A, The morphological changes of BMSCs over 7 days (10×); B, The bar graph demonstrates that the percentage of neural-like BMSCs increases when co-cultured with RGCs. p≤0.05 at all time points. (10 pictures were taken randomly under a regular microscope from culturing cells at different time points. The average relative percent of neural-like BMSCs come from at least three separate experiments).</p