Direct Z‑Scheme In₂O₃/In₂S₃ Heterojunction for Oxygen-Mediated Photocatalytic Hydrogen Production

We demonstrate the viability of the In2O3/In2S3 heterojunction for efficient photocatalytic H2 evolution from a formaldehyde aqueous solution, which is an alternative renewable hydrogen source, in a direct Z-scheme manner under visible light without any electron mediator and cocatalyst. The optimal In2O3/In2S3 heterojunction shows a fast hydrogen evolution rate of 6.16 mmol·g–1·h–1, which is approximately 166 times and 6 times higher than that of pure In2O3 and pure In2S3, respectively. The superior photocatalytic activity of the In2O3/In2S3 heterojunction compared to single-component In2O3 and In2S3 is attributed to its appropriate band gap, enhanced charge separation, and transfer abilities, as attested by various spectroscopic characterization and photoelectrochemistry experiments. Among the different fabrication approaches, the sequential hydrothermal–calcination technique, which produces a hydrangea-like morphology, affords the most active In2O3/In2S3 heterojunction photocatalyst. Molecular O2 is found to play a key role in instigating the photocatalytic H2 evolution from formaldehyde oxidation as a catalytic electron scavenger, which is not consumed throughout the reaction

MoP Nanoflakes as Efficient Electrocatalysts for Rechargeable Li–O₂ Batteries

Herein, we first report a binder-free electrode with <i>in situ</i> synthesized MoP nanoflakes on the surface of carbon cloth and its application in nonaqueous Li–O₂ batteries (LOBs). The assembled LOBs exhibit improved discharge/charge capability (achieving actual 4.15 mAh at a current of 0.1 mA and cycle stability, 400 cycles without capacity fading), which should be attributed to the superior electrocatalytic activity of MoP nanoflakes toward the formation/decomposition of Li₂O₂

Discovery of a Novel Series of Homo sapiens Caseinolytic Protease P Agonists for Colorectal Adenocarcinoma Treatment via ATF3-Dependent Integrated Stress Response

Homo sapiens caseinolytic protease P (HsClpP) activation is a promising strategy for colon cancer treatment. In this study, CCG1423 was identified as a selective activator of HsClpP. After optimization, NCA029 emerged as the most potent compound, with an EC50 of 0.2 μM against HsClpP. Molecular dynamics revealed that the affinity of NCA029 for the YYW aromatic network is crucial for its selectivity toward HsClpP. Furthermore, NCA029 displayed favorable pharmacokinetics and safety profiles and significantly inhibited tumor growth in HCT116 xenografts, resulting in 83.6% tumor inhibition. Mechanistically, NCA029 targeted HsClpP, inducing mitochondrial dysfunction and activating the ATF3-dependent integrated stress response, ultimately causing cell death in colorectal adenocarcinoma. These findings highlight NCA029 as an effective HsClpP activator with potential for colon cancer therapy

Discovery of a Novel Series of Homo sapiens Caseinolytic Protease P Agonists for Colorectal Adenocarcinoma Treatment via ATF3-Dependent Integrated Stress Response

Homo sapiens caseinolytic protease P (HsClpP) activation is a promising strategy for colon cancer treatment. In this study, CCG1423 was identified as a selective activator of HsClpP. After optimization, NCA029 emerged as the most potent compound, with an EC50 of 0.2 μM against HsClpP. Molecular dynamics revealed that the affinity of NCA029 for the YYW aromatic network is crucial for its selectivity toward HsClpP. Furthermore, NCA029 displayed favorable pharmacokinetics and safety profiles and significantly inhibited tumor growth in HCT116 xenografts, resulting in 83.6% tumor inhibition. Mechanistically, NCA029 targeted HsClpP, inducing mitochondrial dysfunction and activating the ATF3-dependent integrated stress response, ultimately causing cell death in colorectal adenocarcinoma. These findings highlight NCA029 as an effective HsClpP activator with potential for colon cancer therapy

The spatial mask applied to build network.

<p>The spatial mask applied to build network.</p

The 3 selected components and their averaged time courses from Group ICA.

<p>The 3 selected components and their averaged time courses from Group ICA.</p

Scatter Plots of averaged clustering coefficients and local efficiency against RT at medium load.

<p>Scatter plots with trend lines showing averaged <i>C_net</i> and <i>E_local,net</i> as function of reaction time in all subjects and each group. Significant negative correlation (<i>p</i><0.05) was found between reaction time and averaged <i>C_net</i> and <i>E_local,net</i> for all subjects (green line).</p

Original (top) and sorted (bottom) blocks order.

<p>Time courses sorted according to the WM loads within each run. Details are enlarged on the right.</p

Demographics of Subjects and Symptom Scores for SZ.

<p>Demographics of Subjects and Symptom Scores for SZ.</p

Network measures between SZ at high load and HC at medium load.

<p>Green dots above indicate significant group difference (<i>p</i><0.05, FDR corrected) and pink dots above indicate marginally group difference (<i>p</i><0.1, FDR corrected) between HC and SZ at that observation.</p