Selecting cases from nuclear families for case-control association analysis-0

<p><b>Copyright information:</b></p><p>Taken from "Selecting cases from nuclear families for case-control association analysis"</p><p></p><p>BMC Genetics 2005;6(Suppl 1):S105-S105.</p><p>Published online 30 Dec 2005</p><p>PMCID:PMC1866834.</p><p></p>tion, R) and the lower right hand triangle shows pair-wise D' values (labelled d prime). Red indicates values of r or D' close to 1, blue represents values close to 0

Loadings, p values, indirect and overall effects of 12 SNPs, PRS on body shape with adjustment for sex and age.

<p>Loadings, p values, indirect and overall effects of 12 SNPs, PRS on body shape with adjustment for sex and age.</p

Fitted model for the 12 SNPs from the 12 gene regions with adjustment for sex and age for multiple traits (a) as with distribution of its PRS and cumulative effects of these variants (b).

<p>Fitted model for the 12 SNPs from the 12 gene regions with adjustment for sex and age for multiple traits (a) as with distribution of its PRS and cumulative effects of these variants (b).</p

Distribution of body shape types and characteristics of body shape score (BSS) by sex in the EPIC-Norfolk study.

<p>Distribution of body shape types and characteristics of body shape score (BSS) by sex in the EPIC-Norfolk study.</p

PLSPM-based models.

<p>(a) Scan statistic model, where <i>ξ₁</i> represents genomic region containing <i>P</i> SNPs and <i>β₂₁</i> the regional effect on the body shape score <i>ξ₁</i>; (<b>b</b>) Polygenic effect model, where <i>ξ'₁</i> represents polygenic risk score and <i>β'₂₁</i> the polygenic effect. In both models, <i>λ</i>'s are the loadings while <i>β</i>'s are the path coefficients.</p

Characteristics of Stage1 and Stage2 studies.

a<p>See <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044008#pone.0044008.s005" target="_blank">Table S1</a></b> for more information on genotyping, imputation and software used. ^b The characteristics of the studies in the AAGC are presented in Ferreira et al., 2011 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044008#pone.0044008-Ferreira1" target="_blank">[8]</a>. ^c EPIC = European Prospective Investigation into Cancer and Nutrition.</p

Replication results for top signals from APCAT (Stage1 <i>N</i> = 18,604) in additional studies (Stage 2 <i>N</i> = 15,576) and in GABRIEL.

a<p>Positions/alleles are relative to the forward strand of NCBI build36. ^b,cResults from GABRIEL are from a re-analysis using fixed-effects meta-analysis, excluding the B58C and ECRHS2 cohorts which are included in Stage2 or with occupational asthma (see Methods), and are for the APCAT SNP or the best available proxy. All p values are two-tailed.</p