Fumonisins B₁, B₂ and B₃ in corn products, wheat flour and corn oil marketed in Shandong province of China

<div><p>In this study a total of 522 samples were collected from Shandong province of China in 2014 and analysed for the occurrence of fumonisin B1 (FB₁), FB₂ and FB₃ by isotope dilution ultrahigh performance liquid chromatography–tandem mass spectrometry. Fumonisins were detected in 98.1% of the corn products, with the average total level of 369.2 μg kg⁻¹. The individual average values of FB₁, FB₂ and FB₃ in corn products were 268.3, 53.7 and 47.2 μg kg⁻¹, respectively. The simultaneous occurrence of FB₁, FB₂ and FB₃ was observed in 76.7% of the corn products. Especially, the results demonstrated that the difference in the contamination levels for fumonisins in these three types of corn products was apparent. In addition, 6.2% of the wheat flour samples were contaminated with FB₁, with concentrations ranging from 0.3 to 34.6 µg kg⁻¹. No FB₂ or FB₃ was detected in wheat flour. In corn oil samples no fumonisins were detected.</p></div

The proportion of infants with delayed development defined as below 85 standard scores of the Bayley-III in infants who have fetal exposure to clozapine versus those in other atypical antipsychotics group^a.

<p>^aData was expressed as No. (%)</p><p>The proportion of infants with delayed development defined as below 85 standard scores of the Bayley-III in infants who have fetal exposure to clozapine versus those in other atypical antipsychotics group<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0123373#t004fn001" target="_blank">^a</a>.</p

Comparison of maternal characteristics and pregnancy outcomes between clozapine group and other atypical antipsychotics group.

<p>Comparison of maternal characteristics and pregnancy outcomes between clozapine group and other atypical antipsychotics group.</p

The information for antipsychotics using.

<p>The information for antipsychotics using.</p

The infants developments between clozapine and other atypical antipsychotic groups^a.

<p>^aData are expressed as mean (SD).</p><p>The infants developments between clozapine and other atypical antipsychotic groups<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0123373#t003fn001" target="_blank">^a</a>.</p

Additional file 2: of Screening for distress in patients with primary brain tumor using distress thermometer: a systematic review and meta-analysis

Meta-analysis of the prevalence of distress symptoms among brain tumor patients stratified by study design (A), country (B), sample size (C), year (D) and distress scale cut-off (E). CI, confidence interval. (ZIP 6618 kb

Additional file 1: of Screening for distress in patients with primary brain tumor using distress thermometer: a systematic review and meta-analysis

Meta-analysis of the prevalence of distress symptoms among brain tumor patients stratified by study-level characteristics. (DOC 40 kb

Treatment effects of olanzapine on homotopic connectivity in drug-free schizophrenia at rest

<p><b>Objectives:</b> Deficits in homotopic connectivity have been implicated in schizophrenia. However, alterations in homotopic connectivity associated with antipsychotic treatments in schizophrenia remain unclear due to lack of longitudinal studies.</p> <p><b>Methods:</b> Seventeen drug-free patients with recurrent schizophrenia and 24 healthy controls underwent resting-state functional magnetic resonance imaging scans. The patients were scanned at three time points (baseline, at 6 weeks of treatment, and at 6 months of treatment). Voxel-mirrored homotopic connectivity (VMHC) was applied to analyse the imaging data to examine alterations in VMHC associated with antipsychotic treatment.</p> <p><b>Results:</b> The results showed that patients with schizophrenia exhibited decreased VMHC in the default-mode network (such as the precuneus and inferior parietal lobule) and the motor and sensory processing regions (such as the lingual gyrus, fusiform gyrus and cerebellum lobule VI), which could be normalised or denormalised by olanzapine treatment. In addition, negative correlations were found between decreased VMHC and symptom severity in the patients at baseline.</p> <p><b>Conclusions:</b> The present study shows that olanzapine treatment can normalise or denormalise decreased homotopic connectivity in schizophrenia. The findings also provide a new perspective to understand treatment effects of antipsychotic drugs on homotopic connectivity in schizophrenia that contribute to the disconnection hypothesis of this disease.</p

Relative mtDNA copy number of MDD patients and HC.

<p>There is no significant difference in mtDNA copy number between MDD and HC.</p

Comparison of mtDNA copy number between the MDD group and the HC group, and comparison of mtDMA copy number within the MDD group.

<p>MDD: major depressive disorder; HC: healthy controls; HDRS: Hamilton Depression Rating Scale.</p><p>p calculated by the t-test.</p><p>^* Patients are considered to be currently suffered from depression with a score of ≥18 on the HDRS, while are defined as being in remission if they had an HDRS score less than 18.</p