Development and standardisation of Laghu Sudarshan Churna – An Ayurvedic polyherbal formulation

106-112Laghu Sudarshan Churna, LSC is an Ayurvedic polyherbal formulation employed for different types of jvaras (fevers). The present study was undertaken to prepare its standardised formulation and to standardise the finished product using quality control procedures mentioned in Ayurvedic Pharmacopoeia of India (API). For this, four batches of the finished products were prepared on a laboratory scale and performed the pharmacognostical parameters (macroscopic, microscopic and powder drug analysis); thin layer chromatography; quantitative physicochemical evaluation including loss on drying, total ash, acid-insoluble ash, alcohol & water soluble extractive values, and pH; & measuring the level of aflatoxins, microbial load, heavy metals and pesticide residues of the finished product. This study is the foremost effort to develop the standardised formulation along with the evaluation parameters for LSC. Thus, obtained results would be beneficial and will act as the reference for the standardisation of LSC

MARKET ASPECTS, THERAPEUTIC ADVANCEMENTS AND SYNERGISTIC POTENTIAL OF BLACK PEPPER

Black pepper (Piper nigrum L.) is widely regarded as the "king of spices" due to its enormous trading share in the world market. This worldwide trade is not only attributed to its pungency properties, but widely due to its great health benefits and richness in the bioactive components. From the ancient times to the modern science, the black pepper has evolved as a one of the important medicinal agents which is not only used in the kitchen for its nutritional and heath properties, but widely employed in the pharmaceutical sciences for its scientifically proven pharmacological actions and therapeutic role. These actions are mainly due to the presence of the alkaloids, flavonoids, steroids, phenols, amides, lignans, essential oil etc. Piperine, a piperidine alkaloid and its derivatives are widely employed as a bioavailability enhancer and produces synergistic effects with many other phytoconstituents or medicinal drugs and contribute to improve the bioactivity, dose reduction, and even lessen the side effects of many pharmaceutical drugs. Black pepper is widely employed to increase appetite, treats the hypertension, cough, sinusitis, vomiting, epilepsy, gastric problems, dyspnea, worm infections, and skin diseases. It also found to possess several important pharmacological properties such as antimicrobial, analgesic, anti-inflammatory, antioxidant, anticonvulsant, hypolipidemic, hypoglycemic, hepatoprotective, neuroprotective, and anticancer activities. Due to these wide applications, the trade of black pepper is increasing day-by-day all the world. The black pepper is mainly produced throughout the world especially in Vietnam, India, Indonesia, Brazil, Malaysia, China, and Sri Lanka. In India, Karnataka, and Kerala account for almost 55 % and 34 % of the total production respectively. The present review outlined the recent advancements in therapeutic potential of black pepper (Piper nigrum L.) along with its synergism and analysed the trade performance in terms of area, production, import and export of black pepper in the world focusing on India

Development of quality control parameters for classical ayurvedic formulation: Vyoshadi Churna

Introduction: Ayurvedic formulations have a long history of use and have increased amazingly to follow the global interest in natural products. However, for many classical ayurvedic formulations, no quality parameters of standardization are available. Vyoshadi Churna, a classical Ayurvedic polyherbal formulation that cures indigestion and diarrhea, is being used since ancient times. However, there is no standard method available for its formulation and evaluation. Hence, the current study aims to develop the quality standards for Vyoshadi churna. Methods: The standard procedures for preparation and standardization of Churna described in Ayurvedic Pharmacopoeia of India (API) were used in the present study. Standardization includes pharmacognostical, chromatographic, and physico-chemical studies. The other essential studies were also done in accordance to API and World Health Organization guidelines to find the limits of microbial load, aflatoxin, heavy metals, and pesticide residue using modern analytical techniques such as gas chromatography-mass spectroscopy (MS) and inductively coupled plasma-MS/MS. Results: Vyoshadi Churna is of brown color and bitter in taste. Pharmacognostical studies have shown the characteristic features of almost each contributory crude drug. A unique chemical profile was also developed using toluene: ethyl acetate: methanol: formic acid (4:4:1:0.5) as the mobile phase to resolve maximum components. Furthermore, the standardized limits for the physicochemical studies, microbial load, heavy metals, aflatoxins, and pesticide residues were established and found in limits. Conclusion: This is for the first time when the standard operating procedure of Vyoshadi Churna was developed. Hence, the current technical work would be practically helpful for the future preparation and standardization study of Vyoshadi Churna

Development and standardisation of Laghu Sudarshan Churna – An Ayurvedic polyherbal formulation

Laghu Sudarshan Churna, LSC is an Ayurvedic polyherbal formulation employed for different types of jvaras (fevers). The present study was undertaken to prepare its standardised formulation and to standardise the finished product using quality control procedures mentioned in Ayurvedic Pharmacopoeia of India (API). For this, four batches of the finished products were prepared on a laboratory scale and performed the pharmacognostical parameters (macroscopic, microscopic and powder drug analysis); thin layer chromatography; quantitative physicochemical evaluation including loss on drying, total ash, acid-insoluble ash, alcohol & water soluble extractive values, and pH; & measuring the level of aflatoxins, microbial load, heavy metals and pesticide residues of the finished product. This study is the foremost effort to develop the standardised formulation along with the evaluation parameters for LSC. Thus, obtained results would be beneficial and will act as the reference for the standardisation of LSC