Association between quartile of BALF protein expression and clinical parameters.

<p>The mean values of age, pack years, FEV1% predicted, FEV1/FVC % predicted, TLC % predicted, CT score and St. George questionnaire total score were calculated for each quartile of MMP-1, -9, -12 and TIMP-1 BALF protein expression. Bold indicates p<0.05 compared to quartile 1. Parentheses () indicate standard deviation.</p

Correlation between plasma MMP/TIMP levels and % change in FEV1.

<p>Plasma protein levels for MMP-1, -9 and TIMP-1 were correlated with the % change from baseline in FEV1 at 6, 9 and 18 months of follow up. The coefficient of determination (R²) was calculated for each value at each time point.</p

Correlation between BALF MMP/TIMP levels and % change in FEV1.

<p>BALF protein levels for MMP-1, -9 and TIMP-1 were correlated with the % change from baseline in FEV1 at 6, 9 and 18 months of follow up. The coefficient of determination (R²) was calculated for each value at each time point.</p

Patient Demographics.

<p>Data are presented as mean ± standard deviation.</p

Quartiles of MMP protein expression.

<p>Minimum to 25% represented quartile 1 (Q1), 26% to Median represented quartile 2 (Q2), Median to 75% represented quartile 3 (Q3) and 75% to Maximum represented quartile 4 (Q4).</p

Correlation between MMPs and DL_CO or FEV1/FVC % predicted.

<p>Linear regression analyses correlated baseline BALF MMP-1, -9, -12 and TIMP-1 lavage levels with change in DL_CO or the FEV1/FVC % predicted ratio at 9-month follow up. R² = coefficient of correlation.</p

Correlation between baseline and follow up BALF and plasma MMP/TIMP levels.

<p>Baseline BALF and plasma protein levels for MMP-1, -9 and TIMP-1 were correlated with follow up MMP/TIMP levels that were collected and measured 3 or 6 months following the baseline tests. The coefficient of determination (R²) was calculated for each value at each time point.</p

Coefficients of correlation (R²) between elastase and collagenase activity and COPD disease parameters.

<p>The coefficient of correlation (R²) was calculated for elastase and collagenase activity and age, pack years, FEV1, FEV1/FVC, TLC, CT score, D_LCO and St. George total score.</p><p>PFT parameters are reported in % predicted post bronchodilator.</p

MMP and TIMP-1 levels in the plasma of normal smokers and emphysema subjects.

<p>Luminex multiplex assays for MMP-1 (top panel), MMP-9 (center panel) and TIMP-1 (bottom panel) were done on age-matched plasma samples from non-smoking controls, normal smokers and subjects with moderate to severe emphysema. MMP-12 was measured but levels were below the limit of detection.</p

Association between quartile of plasma protein expression and clinical parameters.

<p>The mean values of age, pack years, FEV1% predicted, FEV1/FVC % predicted, TLC % predicted, CT score and St. George questionnaire total score were calculated for each quartile of MMP-1, -9 and TIMP-1 plasma protein expression. Bold indicates p<0.05 compared to quartile 1. Parentheses () indicate standard deviation.</p