Regiodivergent Synthesis of Functionalized Indene Derivatives via Pt-Catalyzed Rautenstrauch Reaction of Propargyl Carbonates

A regiodivergent synthesis of functionalized indene derivatives from a Pt-catalyzed Rautenstrauch reaction of propargyl carbonate is described. A one-pot Rautenstrauch/Tsuji–Trost reaction delivering 2-indanones was realized efficiently using this methodology

Synthesis of Imidazo[4,5-<i>b</i>]pyridines and Imidazo[4,5-<i>b</i>]pyrazines by Palladium Catalyzed Amidation of 2-Chloro-3-amino-heterocycles

A facile synthesis of imidazo[4,5-<i>b</i>]pyridines and -pyrazines is described using a Pd-catalyzed amide coupling reaction. This reaction provides quick access to products with substitution at N1 and C2. A model system relevant to the natural product pentosidine has been demonstrated, as well as the total synthesis of the mutagen 1-Me-5-PhIP

Catalytically Generated Allyl Cu(I) Intermediate via Cyclopropene Ring-Opening Coupling en Route to Allylphosphonates

An efficient generation of functionalized allyl copper­(I) species via cyclopropene ring-opening coupling reaction is reported, which enables stereoselective access to allylphosphonates. Mechanistic studies uncovered stereochemistry to be controlled by both ligand and substrate electronics, with the latter likely arising from pronounced arene-Cu­(I) interaction in electron-deficient substrates. The study unravels a novel approach to access functionalized nucleophilic allylcopper species upon which three-component coupling reactions might be developed

Image_2_Pseudoprogression after advanced first-line endocrine therapy in metastatic breast cancer with bone metastasis: A case report.tif

Approximately 75% of patients with advanced breast cancer develop bone metastasis, which significantly affects both the quality of life and the survival rate of patients. Accurate determination of the status of bone metastases is important for developing treatment strategies and the prognosis of the disease. Here, we report the case of a 33-year-old patient with advanced metastatic breast cancer (MBC) and multiple bone metastases, in which advanced first-line endocrine therapy and second-line chemotherapy were both considered unsuccessful according to the efficacy evaluation by conventional imaging. Considering the possibility of bone pseudoprogression, the original endocrine scheme was reapplied, and bone metastases achieved a great response of non-complete response (CR)/non-progressive disease (PD). This case showed that, in the course of therapy for the disease, if bone scintigraphy (BS) shows increased lesion density or new lesions, this probably indicates a favorable response (osteoblastic repair of osteolytic lesions) to therapy, and not the worsening of metastatic lesions, called bone pseudoprogression. This paper will provide new insights into strategies for the treatment of bone metastasis and shows the significance of distinguishing osteoblastic bone repair from real bone lesion progression in clinical settings.</p

Image_3_Pseudoprogression after advanced first-line endocrine therapy in metastatic breast cancer with bone metastasis: A case report.tif

Approximately 75% of patients with advanced breast cancer develop bone metastasis, which significantly affects both the quality of life and the survival rate of patients. Accurate determination of the status of bone metastases is important for developing treatment strategies and the prognosis of the disease. Here, we report the case of a 33-year-old patient with advanced metastatic breast cancer (MBC) and multiple bone metastases, in which advanced first-line endocrine therapy and second-line chemotherapy were both considered unsuccessful according to the efficacy evaluation by conventional imaging. Considering the possibility of bone pseudoprogression, the original endocrine scheme was reapplied, and bone metastases achieved a great response of non-complete response (CR)/non-progressive disease (PD). This case showed that, in the course of therapy for the disease, if bone scintigraphy (BS) shows increased lesion density or new lesions, this probably indicates a favorable response (osteoblastic repair of osteolytic lesions) to therapy, and not the worsening of metastatic lesions, called bone pseudoprogression. This paper will provide new insights into strategies for the treatment of bone metastasis and shows the significance of distinguishing osteoblastic bone repair from real bone lesion progression in clinical settings.</p

Image_1_Pseudoprogression after advanced first-line endocrine therapy in metastatic breast cancer with bone metastasis: A case report.tif

Approximately 75% of patients with advanced breast cancer develop bone metastasis, which significantly affects both the quality of life and the survival rate of patients. Accurate determination of the status of bone metastases is important for developing treatment strategies and the prognosis of the disease. Here, we report the case of a 33-year-old patient with advanced metastatic breast cancer (MBC) and multiple bone metastases, in which advanced first-line endocrine therapy and second-line chemotherapy were both considered unsuccessful according to the efficacy evaluation by conventional imaging. Considering the possibility of bone pseudoprogression, the original endocrine scheme was reapplied, and bone metastases achieved a great response of non-complete response (CR)/non-progressive disease (PD). This case showed that, in the course of therapy for the disease, if bone scintigraphy (BS) shows increased lesion density or new lesions, this probably indicates a favorable response (osteoblastic repair of osteolytic lesions) to therapy, and not the worsening of metastatic lesions, called bone pseudoprogression. This paper will provide new insights into strategies for the treatment of bone metastasis and shows the significance of distinguishing osteoblastic bone repair from real bone lesion progression in clinical settings.</p

Ethylene Transposition: Ruthenium Hydride Catalyzed Intramolecular <i>trans</i>-Silylvinylation of Internal Alkynes

A highly selective intramolecular <i>trans</i>-silylvinylation of internal alkynes catalyzed by RuHCl­(CO)­(SIMes)­(PPh₃) has been accomplished. The use of methyl vinyl ketone as an additive increased the efficiency of this transformation. This process was used to successfully form five-, six-, and seven-membered oxasilacycles by a formal anti-exo-dig cyclization

Copper-Catalyzed Hydroxyl-Directed Aminoarylation of Alkynes

A facile, copper-catalyzed aminoarylation reaction of various aryl/alkyl alkynes was realized by utilizing <i>N</i>-fluoroarylsulfonimides (NFSI) as aminoarylation or amination reagent with hydroxyl as directing group. With this methodology, various α,β-unsaturated carbonyl compounds and indenones were efficiently constructed, and the synthetic application for indole derivatives was also provided. The aminoarylation reactions operate via a regiospecific addition of copper-coordinated nitrogen radical to C–C triple bond/C_vinyl–C_aryl bond formation followed by other series of radical processes

Assembly of Two Porous Cadmium(II) Frameworks: Selective Adsorption and Luminescent Property

Two microporous cadmium­(II) metal–organic frameworks, [Cd­(cptpy)­(Ac)­(H₂O)·(DMA)­(H₂O)]_<i>n</i> (<b>1</b>) and [Cd­(cptpy)₂·(DMF)₂]_<i>n</i> (<b>2</b>) (Hcptpy = 4-(4-carboxyphenyl)-2,2′:4′,4″-terpyridine, DMA = <i>N</i>,<i>N</i>-dimethylacetamide, DMF = dimethylformamide) have been solvothermally synthesized under different reaction conditions. Complex <b>1</b> is a double-interpenetrating 3D network, while <b>2</b> is a noninterpenetrating (3,5)-connected 2D framework. The dehydrated forms of compounds <b>1</b> and <b>2</b> exhibit selective adsorption of CO₂ over N₂ and H₂O over CH₃OH. In addition, the adsorption value of CO₂ for <b>2</b> is higher than that of <b>1.</b> The contents of uncoordinated pyridine nitrogen (Lewis basic sites) per formula unit of <b>1</b> and <b>2</b> are 2.16 and 4.36%, respectively. Obviously, the grafting of more uncoordinated pyridine nitrogen into compound <b>2</b> could enhance adsorption of the acidic CO₂ molecule. Notably, both <b>1</b> and <b>2</b> display strong photoluminescence. The nature of electronic transitions for complex <b>1</b> in the photoluminescent process was investigated by means of time-dependent density functional theory (TDDFT) calculations and molecular orbital analyses, which collaborates that the luminescent property is ligand-based

Assembly of Two Porous Cadmium(II) Frameworks: Selective Adsorption and Luminescent Property

Two microporous cadmium­(II) metal–organic frameworks, [Cd­(cptpy)­(Ac)­(H₂O)·(DMA)­(H₂O)]_<i>n</i> (<b>1</b>) and [Cd­(cptpy)₂·(DMF)₂]_<i>n</i> (<b>2</b>) (Hcptpy = 4-(4-carboxyphenyl)-2,2′:4′,4″-terpyridine, DMA = <i>N</i>,<i>N</i>-dimethylacetamide, DMF = dimethylformamide) have been solvothermally synthesized under different reaction conditions. Complex <b>1</b> is a double-interpenetrating 3D network, while <b>2</b> is a noninterpenetrating (3,5)-connected 2D framework. The dehydrated forms of compounds <b>1</b> and <b>2</b> exhibit selective adsorption of CO₂ over N₂ and H₂O over CH₃OH. In addition, the adsorption value of CO₂ for <b>2</b> is higher than that of <b>1.</b> The contents of uncoordinated pyridine nitrogen (Lewis basic sites) per formula unit of <b>1</b> and <b>2</b> are 2.16 and 4.36%, respectively. Obviously, the grafting of more uncoordinated pyridine nitrogen into compound <b>2</b> could enhance adsorption of the acidic CO₂ molecule. Notably, both <b>1</b> and <b>2</b> display strong photoluminescence. The nature of electronic transitions for complex <b>1</b> in the photoluminescent process was investigated by means of time-dependent density functional theory (TDDFT) calculations and molecular orbital analyses, which collaborates that the luminescent property is ligand-based