Risk factors of Metabolic Syndrome and Lifestyle in Early Adulthood in Korea

The objective of this study was to identify risk factors of metabolic syndrome in early adulthood which has currently shown an increase in Korea, due to a westernized lifestyle. Health medical examination data collected from a total of 5801 participants, gathered by the National Health Insurance Service(NHIS) in 2013, was used to proceed with the study. NCEP ATP-III was used as diagnostic criteria for determining metabolic syndrome. The prevalence rate for metabolic syndrome totaled 32.8%, 29.7% for men and 3.1% for women. Among the subjects, 21.5% of men were found to have abnormal waist circumferences compared to a percentage of 2.3% for women. However, the HDL-cholesterol levels for both men and women were very similar, at 13.6% and 13.3% respectively. There were statistically significant differences in their BMIs, family histories of diabetes, smoking periods, smoking frequencies, alcohol consumption, drinking frequencies, and intense physical activities for the metabolic syndrome group and the normal group. The factors influencing metabolic syndrome were BMI(OR=1.645, 95% CI, 1.599-1.692), a high risk of diabetes(OR=8.818, 95% CI, 4.493-17.306), drinking frequency(OR=1.151, 95% CI, 1.074-1.233), smoking period(OR=1.037, 95% CI, 1.010-1.064), whereas the family history of diabetes, smoking frequency, and physical activity showed no significance. The factors attributing to a high risk in diabetes were BMI(OR=1.021, 95% CI, 1.008-1.035), family history of diabetes(OR=1.835, 95% CI, 1.045-3.225), smoking period(OR=1.125, 95% CI, 1.050-1.206), presence of metabolic syndrome(OR=8.519, 95% CI, 4.876-14.885). The result from the data illustrates the necessity in developing programs and management education for such factors (BMI, smoking, drinking) that influence metabolic syndrome in early adulthood. Promotion of the environment and social awareness of metabolic syndrome is also required to make possible improvements in lifestyle

Stratifying the early radiologic trajectory in dyspneic patients with COVID-19 pneumonia

OBJECTIVE: This study aimed to stratify the early pneumonia trajectory on chest radiographs and compare patient characteristics in dyspneic patients with coronavirus disease 2019 (COVID-19). MATERIALS AND METHODS: We retrospectively included 139 COVID-19 patients with dyspnea (87 men, 62.7+/-16.3 years) and serial chest radiographs from January to September 2020. Radiographic pneumonia extent was quantified as a percentage using a previously-developed deep learning algorithm. A group-based trajectory model was used to categorize the pneumonia trajectory after symptom onset during hospitalization. Clinical findings, and outcomes were compared, and Cox regression was performed for survival analysis. RESULTS: Radiographic pneumonia trajectories were categorized into four groups. Group 1 (n = 83, 59.7%) had negligible pneumonia, and group 2 (n = 29, 20.9%) had mild pneumonia. Group 3 (n = 13, 9.4%) and group 4 (n = 14, 10.1%) showed similar considerable pneumonia extents at baseline, but group 3 had decreasing pneumonia extent at 1-2 weeks, while group 4 had increasing pneumonia extent. Intensive care unit admission and mortality were significantly more frequent in groups 3 and 4 than in groups 1 and 2 (P \u3c .05). Groups 3 and 4 shared similar clinical and laboratory findings, but thrombocytopenia ( \u3c 150x103/muL) was exclusively observed in group 4 (P = .016). When compared to groups 1 and 2, group 4 (hazard ratio, 63.3; 95% confidence interval, 7.9-504.9) had a two-fold higher risk for mortality than group 3 (hazard ratio, 31.2; 95% confidence interval, 3.5-280.2), and this elevated risk was maintained after adjusting confounders. CONCLUSION: Monitoring the early radiologic trajectory beyond baseline further prognosticated at-risk COVID-19 patients, who potentially had thrombo-inflammatory responses

Comparison Of Interpolation Technique For Rain Gauge Data Through The Distributed Rainfall-Runoff Model

Precipitation estimated from different measuring techniques such as rain gauge, radar and satellite have some similarities, but there are also differences among them. For example, techniques based on radar and satellite data underestimate rainfall than those using rain gauge data. In addition, many different interpolation techniques have been used to measure spatial pattern of precipitation but it is still difficult to have an accurate pattern by any one of them. The differences between the rainfall estimates from different techniques vary seasonally as well as regionally so that the radar or satellites are not directly applied into hydrologic analysis. In this regard, a main objective of this study is to develop a systematic way to interpolate ground rain gauge using discharge data from distributed rainfall-runoff model The spatial rainfall patterns estimated from the interpolation methods will be evaluated with the object function to minimize the difference between observed and estimated discharge. In other words, this study seeks to identify the optimal spatial pattern in rain field that can generate a similar pattern of observed discharge through the distributed rainfall-runoff model. This study will compare the spatial pattern from different types of climate systems and different seasons derived from different interpolation methods may help to validate the proposed algorithms

Production of Transgenic Cloned Miniature Pigs with Membrane-bound Human Fas Ligand (FasL) by Somatic Cell Nuclear Transfer

Cell-mediated xenograft rejection, including NK cells and CD8+ CTL, is a major obstacle in successful pig-to-human xenotransplantation. Human CD8+ CTL and NK cells display high cytotoxicity for pig cells, mediated at least in part by the Fas/FasL pathway. To prevent cell-mediated xenocytotoxicity, a membrane-bound form of human FasL (mFasL) was generated as an inhibitor for CTL and NK cell cytotoxicity that could not be cleaved by metalloproteinase to produce putative soluble FasL. We produced two healthy transgenic pigs harboring the mFasL gene via somatic cell nuclear transfer (SCNT). In a cytotoxicity assay using transgenic clonal cell lines and transgenic pig ear cells, the rate of CD8+ CTL-mediated cytotoxicity was significantly reduced in transgenic pig's ear cells compared with that in normal minipig fetal fibroblasts. Our data indicate that grafts of transgenic pigs expressing membrane-bound human FasL control the cellular immune response to xenografts, creating a window of opportunity to facilitate xenograft survival

A Comprehensive Analysis of 5G Heterogeneous Cellular Systems operating over κ\kappa-μ\mu Shadowed Fading Channels

Emerging cellular technologies such as those proposed for use in 5G communications will accommodate a wide range of usage scenarios with diverse link requirements. This will include the necessity to operate over a versatile set of wireless channels ranging from indoor to outdoor, from line-of-sight (LOS) to non-LOS, and from circularly symmetric scattering to environments which promote the clustering of scattered multipath waves. Unfortunately, many of the conventional fading models adopted in the literature to develop network models lack the flexibility to account for such disparate signal propagation mechanisms. To bridge the gap between theory and practical channels, we consider $\kappa$-$\mu$ shadowed fading, which contains as special cases, the majority of the linear fading models proposed in the open literature, including Rayleigh, Rician, Nakagami-m, Nakagami-q, One-sided Gaussian, $\kappa$-$\mu$, $\eta$-$\mu$, and Rician shadowed to name but a few. In particular, we apply an orthogonal expansion to represent the $\kappa$-$\mu$ shadowed fading distribution as a simplified series expression. Then using the series expressions with stochastic geometry, we propose an analytic framework to evaluate the average of an arbitrary function of the SINR over $\kappa$-$\mu$ shadowed fading channels. Using the proposed method, we evaluate the spectral efficiency, moments of the SINR, bit error probability and outage probability of a $K$-tier HetNet with $K$ classes of BSs, differing in terms of the transmit power, BS density, shadowing characteristics and small-scale fading. Building upon these results, we provide important new insights into the network performance of these emerging wireless applications while considering a diverse range of fading conditions and link qualities

Effect of Information Disclosure Policy on Control of Infectious Disease:MERS-CoV Outbreak in South Korea

This study examined the effect of disclosing a list of hospitals with Middle East respiratory syndrome coronavirus (MERS-CoV) patients on the number of laboratory-confirmed MERS-CoV cases in South Korea. MERS-CoV data from 20 May 2015 to 5 July 2015 were from the Korean Ministry of Health & Welfare website and analyzed using segmented linear autoregressive error models for interrupted time series. This study showed that the number of laboratory-confirmed cases was increased by 14.629 on June 5 (p < 0.001). However, this number was significantly decreased following disclosure of a list of hospitals with MERS-CoV cases (Estimate = −0.948; p < 0.001). Disclosing the list of hospitals exposed to MERS-CoV was critical to the prevention of further infection. It reduced the number of confirmed MERS-CoV cases. Thus, providing accurate and timely information is a key to critical care response

Characteristics of injury of the corticospinal tract and corticoreticular pathway in hemiparetic patients with putaminal hemorrhage

BACKGROUND: No study on the characteristics of injury of the corticospinal tract (CST) or corticoreticular pathway (CRP) in patients with putaminal hemorrhage has been reported. In this study, using diffusion tensor tractography, we attempted to investigate the characteristics of injury of the CST and CRP in hemiparetic patients with putaminal hemorrhage. METHOD: Fifty seven consecutive patients with putaminal hemorrhage and 57 healthy control subjects were recruited for this study. Diffusion tensor imaging was performed during the early period (8 ~ 30 days) after onset. We defined injury of the CST or CRP in terms of the configuration (discontinuation of a neural tract) or abnormal DTT parameters (the fractional anisotrophy value or fiber number was more than two standard deviations lower than that of normal control subjects). The Motricity Index, the modified Brunnstrom Classification, and the Functional Ambulation Categories were used for evaluation of motor function. RESULTS: Among 57 patients, injury of the CST was found in 41 patients (71.9%) and injury of the CRP was found in 50 patients (87.8%), respectively, and 37 patients (64.9%) had injury of both the CST and CRP. All three motor functions of patients with injury of both the CST and CRP were significantly lower than those of patients with injury of either the CST or CRP (p < 0.05). CONCLUSION: Our results indicate that the putaminal hemorrhage frequently accompanies injury of both the CST and CRP, and the CRP appears to be more vulnerable to putaminal hemorrhage than the CST. These findings suggest the necessity for evaluation of both the CRP and the CST in patients with putaminal hemorrhage