Universal R-matrix Of The Super Yangian Double DY(gl(1|1))

Based on Drinfeld realization of super Yangian Double DY(gl(1|1)), its pairing relations and universal R-matrix are given. By taking evaluation representation of universal R-matrix, another realization $L^{\pm}(u)$ of DY(gl(1|1)) is obtained. These two realizations of DY(gl(1|1)) are related by the supersymmetric extension of Ding-Frenkel map.Comment: 6 pages, latex, no figure

Explaining 750 GeV diphoton excess from top/bottom partner cascade decay in two-Higgs-doublet model extension

In this paper, we interpret the 750 GeV diphoton excess in the Zee-Babu extension of the two-Higgs-doublet model by introducing a top partner ($T$)/bottom partner ($B$). In the alignment limit, the 750 GeV resonance is identified as the heavy CP-even Higgs boson ($H$), which can be sizably produced via the QCD process $pp \to T\bar{T}$ or $pp \to B\bar{B}$ followed by the decay $T\to Ht$ or $B \to Hb$. The diphoton decay rate of $H$ is greatly enhanced by the charged singlet scalars predicted in the Zee-Babu extension and the total width of $H$ can be as large as 7 GeV. Under the current LHC constraints, we scan the parameter space and find that such an extension can account for the observed diphoton excess.Comment: 19 pages, 4 figures; some discussions and references adde

3-(4-Meth­oxy­benzyl­idene)-1,5-dioxa­spiro­[5.5]undecane-2,4-dione

In the title mol­ecule, C17H18O5, which was prepared by the reaction of (R)-1,5-dioxaspiro­[5.5]undecane-2,4-dione and 4-meth­oxy­benzaldehyde with ethanol, the 1,3-dioxane ring is in a distorted envelope conformation with the spiro C atom forming the flap. The crystal structure is stabilized by weak inter­molecular C—H⋯O hydrogen bonds

Multiple Signaling Pathways Are Involved in the Interleukine-4 Regulated Expression of DC-SIGN in THP-1 Cell Line

Dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) is an important pattern recognition receptor on dendritic cells (DCs), and its expression shows significant cytological and histological specificity, being interleukine-4 (IL-4) dependent. The signaling pathways through which IL-4 regulates expression of DC-SIGN are still unclear. We used phorbol 12-myristate 13-acetate- (PMA-) differentiated THP-1 cells as the in vitro model of monocyte/macrophage cells to study the signaling pathways involved in IL-4-regulated expression of DC-SIGN. We found that a high expression of DC-SIGN could be induced by IL-4 at the levels of mRNA and cell surface protein. Upregulated expression of DC-SIGN was almost completely blocked by the specific inhibitor of ERK pathway, and partly reduced by the specific inhibitors of JAK-STAT and NF-κB pathways. The activation of the three signaling pathways was directly confirmed by testing the phosphorylation of protein kinase within the cytoplasm and nucleus over time. The analysis of cis-acting elements of DC-SIGN promoter showed that the activity of DC-SIGN promoter without Ets-1 transcription factors binding site almost completely disappeared. Our results demonstrated that multiple signaling pathways are involved in IL-4 induced high expression of DC-SIGN on THP-1 cells, in which ERK pathway is the main signaling pathway and mediated by the Ets-1 transcription factors binding site

中药药浴治疗皮肤病概述

Traditional Chinese Medicated bath is one of the ways of external treatment. Treatment for a variety of diseases, such as various dermatosis, rheumatism, joint pain, other diseases,and so on. The drug directly to the lesion site, obvious effect, less toxic side effect. Based on traditional Chinese medicine bath treatment of dermatosis collated and analyzed literature, summarized Traditional Chinese medicine bath treatment dermatosis mechanism, characteristics of treatment, indications, precautions, etc. Provide the daily and clinical application reference for Chinese medicine bath in the treatment of dermatosis.药浴属于外治法之一，是中医传统用药的途径之一，用于治疗各种皮肤病、风湿、关节疼痛等多种疾病。药物直接用于病灶部位，疗效显著，毒副作用小。本文通过对中药药浴治疗皮肤病的文献资料进行归纳整理，分析综述了中药药浴治疗皮肤病的作用机理、用药特点、适应症、注意事项等，为中药药浴在治疗皮肤病中的日常及临床应用提供参考依据

A Score-based Geometric Model for Molecular Dynamics Simulations

Molecular dynamics (MD) has long been the \emph{de facto} choice for modeling complex atomistic systems from first principles, and recently deep learning become a popular way to accelerate it. Notwithstanding, preceding approaches depend on intermediate variables such as the potential energy or force fields to update atomic positions, which requires additional computations to perform back-propagation. To waive this requirement, we propose a novel model called ScoreMD by directly estimating the gradient of the log density of molecular conformations. Moreover, we analyze that diffusion processes highly accord with the principle of enhanced sampling in MD simulations, and is therefore a perfect match to our sequential conformation generation task. That is, ScoreMD perturbs the molecular structure with a conditional noise depending on atomic accelerations and employs conformations at previous timeframes as the prior distribution for sampling. Another challenge of modeling such a conformation generation process is that the molecule is kinetic instead of static, which no prior studies strictly consider. To solve this challenge, we introduce a equivariant geometric Transformer as a score function in the diffusion process to calculate the corresponding gradient. It incorporates the directions and velocities of atomic motions via 3D spherical Fourier-Bessel representations. With multiple architectural improvements, we outperforms state-of-the-art baselines on MD17 and isomers of C7O2H10. This research provides new insights into the acceleration of new material and drug discovery

Influencing factors on efficacy of summer acupoint application treatment for allergic rhinitis: a retrospective study

AbstractObjectiveAllergic rhinitis (AR) is a common health problem. Summer acupoint application treatment (SAAT) is reported to effectively treat and prevent AR from seasonal onset. In the present study, we aimed to evaluate its effects, especially on the course of AR, through a retrospective study.MethodA cross-sectional multicenter study was performed based on patients treated between 2008 and 2009 in 13 clinical centers in China. A total of 1058 outpatients aged ≥2 years with documented AR and ≥1 year SAAT were eligible for enrollment. A case report form (CRF) was completed by both patient and doctor. The CRF was designed to collect data on the patient's history of SAAT, AR condition, and self-reported health condition. The outcomes (dependent variables) were incidence and intensity of AR and concomitant medications used. Data were analyzed with ordinal logistic regression (OLR).ResultsTreatment course and seasonal pattern of AR were related to all dependent variables positively. After controlling for sample bias and confounding factors, the findings suggested that a 3-year treatment course had better efficacy (OR/incidence of AR: 2.57, 95% CI: 1.76–3.76; OR/intensity of AR: 2.17, 95%CI: 1.50–3.17; OR/concomitant medications: 2.20, 95% CI: 1.50–3.23) compared with a 2-year or less treatment course.ConclusionThe results showed that: 1) the length of treatment course was positively associated with the efficacy of SAAT (the longer the treatment course, the better the efficacy); and 2) SAAT was more efficacious in treating seasonal AR than non-seasonal AR

Stability Analysis of ITER Side Correction Coils

AbstractThe stability of the Side Correction Coils (SCC) cable-in-conduit conductors (CICC) for the International Thermonuclear Experimental Reactor (ITER) has been analyzed by the formulas and the code Gandalf. This paper describes the 1-dimensional mathematical code Gandalf, uses the code to simulate the quench and the recovery status of ITER SCC CICC, discusses the dependence of the stability margin on various operating parameters including operating current, operating temperature and mass flow rate, and analyzes the differences between the simulated values and the calculated values. The ITER SCC's quenching is also simulated to investigate its temperature distribution and temperature margin. Dependence of temperature margin on magnetic fields and operating temperature has been researched. The studies of ITER SCC provide a basis for the stable operation and optimization design of SCC CICC