4,343 research outputs found
The Role of BMP Signaling in Endothelial Heterogeneity
Bone morphogenetic proteins (BMPs), which compose the largest group of the transforming growth factor-β (TGF-ß) superfamily, have been implied to play a crucial role in diverse physiological processes. The most intriguing feature of BMP signaling is that it elicits heterogeneous responses from cells with equivalent identity, thus permitting highly context-dependent signaling outcomes. In endothelial cells (ECs), which are increasingly perceived as a highly heterogeneous population of cells with respect to their morphology, function, as well as molecular characteristics, BMP signaling has shown to elicit diverse and often opposite effects, illustrating the innate complexity of signaling responses. In this review, we provide a concise yet comprehensive overview of how outcomes of BMP signaling are modulated in a context-dependent manner with an emphasis on the underlying molecular mechanisms and summarize how these regulations of the BMP signaling promote endothelial heterogeneity
GaAs droplet quantum dots with nanometer-thin capping layer for plasmonic applications
We report on the growth and optical characterisation of droplet GaAs quantum
dots with extremely-thin (11 nm) capping layers. To achieve such result, an
internal thermal heating step is introduced during the growth and its role in
the morphological properties of the quantum dots obtained is investigated via
scanning electron and atomic force microscopy. Photoluminescence measurements
at cryogenic temperatures show optically stable, sharp and bright emission from
single quantum dots, at near-infrared wavelengths. Given the quality of their
optical properties and the proximity to the surface, such emitters are ideal
candidates for the investigation of near field effects, like the coupling to
plasmonic modes, in order to strongly control the directionality of the
emission and/or the spontaneous emission rate, crucial parameters for quantum
photonic applications.Comment: 1 pages, 3 figure
Two distinct red giant branch populations in the globular cluster NGC 2419 as tracers of a merger event in the Milky Way
Recent spectroscopic observations of the outer halo globular cluster (GC) NGC
2419 show that it is unique among GCs, in terms of chemical abundance patterns,
and some suggest that it was originated in the nucleus of a dwarf galaxy. Here
we show, from the Subaru narrow-band photometry employing a calcium filter,
that the red giant-branch (RGB) of this GC is split into two distinct
subpopulations. Comparison with spectroscopy has confirmed that the redder RGB
stars in the [=(Ca] index are enhanced in [Ca/H] by 0.2
dex compared to the bluer RGB stars. Our population model further indicates
that the calcium-rich second generation stars are also enhanced in helium
abundance by a large amount (Y = 0.19). Our photometry, together with
the results for other massive GCs (e.g., Cen, M22, and NGC 1851),
suggests that the discrete distribution of RGB stars in the index might be
a universal characteristic of this growing group of peculiar GCs. The planned
narrow-band calcium photometry for the Local Group dwarf galaxies would help to
establish an empirical connection between these GCs and the primordial building
blocks in the hierarchical merging paradigm of galaxy formation.Comment: 4 pages, 4 figures, 1 table, accepted for the publication in ApJ
Palladium Catalysts for Dehydrogenation of Ammonia Borane with Preferential B−H Activation
Cationic Pd(II) complexes catalyzed the dehydrogenation of ammonia borane in the most efficient manner with the release of 2.0 equiv of H_2 in less than 60 s at 25 °C. Most of the hydrogen atoms were obtained from the boron atom of the ammonia borane. The first step of the dehydrogenation reaction was elaborated using density functional theory calculations
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