300 research outputs found

    Insight into the Modulation of Shaw2 Kv Channels by General Anesthetics: Structural and Functional Studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR

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    The modulation of the Drosophila Shaw2 Kv channel by 1-alkanols and inhaled anesthetics is correlated with the involvement of the S4–S5 linker and C-terminus of S6, and consistent with stabilization of the channel\u27s closed state. Structural analysis of peptides from S4–S5 (L45) and S6 (S6c), by nuclear magnetic resonance and circular dichroism spectroscopy supports that an α-helical conformation was adopted by L45, while S6c was only in an unstable/dynamic partially folded α-helix in dodecylphosphocholine micelles. Solvent accessibility and paramagnetic probing of L45 revealed that L45 lies parallel to the surface of micelles with charged and polar residues pointing towards the solution while hydrophobic residues are buried inside the micelles. Chemical shift perturbation introduced by 1-butanol on residues Gln320, Thr321, Phe322 and Arg323 of L45, as well as Thr423 and Gln424 of S6c indicates possible anesthetic binding sites on these two important components in the channel activation apparatus. Diffusion measurements confirmed the association of L45, S6c and 1-butanol with micelles which suggests the capability of 1-butanol to influence a possible interaction of L45 and S6c in the micelle environment

    Effect of earthquake on stability of subway station and ground motions of surrounding rock masses

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    The effect of earthquakes on the stability of the subway station and ground motions of surrounding rock masses, plays a key role in the seismic design of the subway station to avoid severe damage to subway station itself and adjacent structures. Most of the reported cases in the literatures on the effect of earthquake on ground motions focused on the ground motions without considering underground structures. In this study, the effect of earthquakes on the stability of the subway station, and ground motions of surrounding rock masses were investigated by using the Flac3d. The ground acceleration and safety factor of tunnel lining were highlighted. The results of the numerical analysis indicated the presence of a subway station has a great influence on ground motions, especially for the vertical ground acceleration. The ground acceleration increases with the decrease of buried depth. The amplification factor of ground acceleration is about 1.42. It exists an amplification region above the subway station with the width of 15 m. The safety factor of tunnel lining in subway station has a significant decrease in the maximum decrease rate of 67 %. The safety factor of tunnel lining except for tunnel crown and bottom changes periodic. Ground acceleration will induce extrusion or detach between surrounding rock masses and tunnel lining, and the direction of ground acceleration has a great influence on distribution of safety factor. The side wall and arch feet of tunnel lining is the most unfavorable part. Special attention should be paid to the side wall and arch feet of the subway station during seismic design

    EMS: 3D Eyebrow Modeling from Single-view Images

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    Eyebrows play a critical role in facial expression and appearance. Although the 3D digitization of faces is well explored, less attention has been drawn to 3D eyebrow modeling. In this work, we propose EMS, the first learning-based framework for single-view 3D eyebrow reconstruction. Following the methods of scalp hair reconstruction, we also represent the eyebrow as a set of fiber curves and convert the reconstruction to fibers growing problem. Three modules are then carefully designed: RootFinder firstly localizes the fiber root positions which indicates where to grow; OriPredictor predicts an orientation field in the 3D space to guide the growing of fibers; FiberEnder is designed to determine when to stop the growth of each fiber. Our OriPredictor is directly borrowing the method used in hair reconstruction. Considering the differences between hair and eyebrows, both RootFinder and FiberEnder are newly proposed. Specifically, to cope with the challenge that the root location is severely occluded, we formulate root localization as a density map estimation task. Given the predicted density map, a density-based clustering method is further used for finding the roots. For each fiber, the growth starts from the root point and moves step by step until the ending, where each step is defined as an oriented line with a constant length according to the predicted orientation field. To determine when to end, a pixel-aligned RNN architecture is designed to form a binary classifier, which outputs stop or not for each growing step. To support the training of all proposed networks, we build the first 3D synthetic eyebrow dataset that contains 400 high-quality eyebrow models manually created by artists. Extensive experiments have demonstrated the effectiveness of the proposed EMS pipeline on a variety of different eyebrow styles and lengths, ranging from short and sparse to long bushy eyebrows.Comment: To appear in SIGGRAPH Asia 2023 (Journal Track). 19 pages, 19 figures, 6 table

    Influence of adjacent surface building on seismic response of shallow buried subway station structure

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    Taking the 6-storey frame structure as an example, using FLAC numerical simulation, the influence of the adjacent multi-storey buildings on the seismic response of the metro station structure (including the internal force and bias state of the station structure) is studied systematically, and the relationship between the influence and surrounding rock level change is analyzed. The research shows that the existence of surface buildings has obvious amplification effect on the internal force of the subway station and above. It mainly shows that the eccentricity of the vault of the subway station is increased, and the eccentricity of the arch waist is reduced. It has a great influence on the internal force and distribution range of the station structure. The worse the surrounding rock, the greater the internal force and influence range of the building to the station structure

    Mechanism of crack propagation for K9 glass

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    In order to study the mechanism of crack propagation, the varied cutting-depth scratch experiment is carried out and smoothed particle hydrodynamics (SPH) simulation method is used to assistant the investigation. The SPH simulation results reveal that crack will propagate in the direction where stress concentration exceeds the fracture toughness of K9 glass. The initial crack length in critical transition depth is calculated by combining the critical stress of fracture and the fracture toughness of K9 glass. Based on the effective plastic strain, the relation between scratching depth and crack depth is obtained. The recovery of crack tip is found and explained from the relationship between cutting depth and crack depth. Using the energy balance theory of Griffith, the variation of material internal energy is revealed. Comparing the scratching forces obtained from experiment and simulation, the validity of simulation results is verified. The phenomenon of crack delayed propagation is found in both experiment and simulation. The explanation of mechanism is given

    Get3DHuman: Lifting StyleGAN-Human into a 3D Generative Model using Pixel-aligned Reconstruction Priors

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    Fast generation of high-quality 3D digital humans is important to a vast number of applications ranging from entertainment to professional concerns. Recent advances in differentiable rendering have enabled the training of 3D generative models without requiring 3D ground truths. However, the quality of the generated 3D humans still has much room to improve in terms of both fidelity and diversity. In this paper, we present Get3DHuman, a novel 3D human framework that can significantly boost the realism and diversity of the generated outcomes by only using a limited budget of 3D ground-truth data. Our key observation is that the 3D generator can profit from human-related priors learned through 2D human generators and 3D reconstructors. Specifically, we bridge the latent space of Get3DHuman with that of StyleGAN-Human via a specially-designed prior network, where the input latent code is mapped to the shape and texture feature volumes spanned by the pixel-aligned 3D reconstructor. The outcomes of the prior network are then leveraged as the supervisory signals for the main generator network. To ensure effective training, we further propose three tailored losses applied to the generated feature volumes and the intermediate feature maps. Extensive experiments demonstrate that Get3DHuman greatly outperforms the other state-of-the-art approaches and can support a wide range of applications including shape interpolation, shape re-texturing, and single-view reconstruction through latent inversion

    HairStep: Transfer Synthetic to Real Using Strand and Depth Maps for Single-View 3D Hair Modeling

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    In this work, we tackle the challenging problem of learning-based single-view 3D hair modeling. Due to the great difficulty of collecting paired real image and 3D hair data, using synthetic data to provide prior knowledge for real domain becomes a leading solution. This unfortunately introduces the challenge of domain gap. Due to the inherent difficulty of realistic hair rendering, existing methods typically use orientation maps instead of hair images as input to bridge the gap. We firmly think an intermediate representation is essential, but we argue that orientation map using the dominant filtering-based methods is sensitive to uncertain noise and far from a competent representation. Thus, we first raise this issue up and propose a novel intermediate representation, termed as HairStep, which consists of a strand map and a depth map. It is found that HairStep not only provides sufficient information for accurate 3D hair modeling, but also is feasible to be inferred from real images. Specifically, we collect a dataset of 1,250 portrait images with two types of annotations. A learning framework is further designed to transfer real images to the strand map and depth map. It is noted that, an extra bonus of our new dataset is the first quantitative metric for 3D hair modeling. Our experiments show that HairStep narrows the domain gap between synthetic and real and achieves state-of-the-art performance on single-view 3D hair reconstruction.Comment: CVPR 2023 Highlight, project page: https://paulyzheng.github.io/research/hairstep
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