The art of defense: letting networks fool the attacker

Some deep neural networks are invariant to some input transformations, such as Pointnet is permutation invariant to the input point cloud. In this paper, we demonstrated this property could be powerful in defense of gradient-based attacks. Specifically, we apply random input transformation which is invariant to the networks we want to defend. Extensive experiments demonstrate that the proposed scheme defeats various gradient-based attackers in the targeted attack setting, and breaking the attack accuracy into nearly zero. Our code is available at: {\footnotesize{\url{https://github.com/cuge1995/IT-Defense}}}

The Tianlin Mission: a 6m UV/Opt/IR space telescope to explore the habitable worlds and the universe

[Abridged] It is expected that the ongoing and future space-borne planet survey missions including TESS, PLATO, and Earth 2.0 will detect thousands of small to medium-sized planets via the transit technique, including over a hundred habitable terrestrial rocky planets. To conduct a detailed study of these terrestrial planets, particularly the cool ones with wide orbits, the exoplanet community has proposed various follow-up missions. The currently proposed ESA mission ARIEL is capable of characterization of planets down to warm super-Earths mainly using transmission spectroscopy. The NASA 6m UV/Opt/NIR mission proposed in the Astro2020 Decadal Survey may further tackle down to habitable rocky planets, and is expected to launch around 2045. In the meanwhile, China is funding a concept study of a 6-m class space telescope named Tianlin (A UV/Opt/NIR Large Aperture Space Telescope) that aims to start its operation within the next 10-15 years and last for 5+ years. Tianlin will be primarily aimed to the discovery and characterization of rocky planets in the habitable zones (HZ) around nearby stars and to search for potential biosignatures mainly using the direct imaging method. Transmission and emission spectroscopy at moderate to high resolution will be carried out as well on a population of exoplanets to strengthen the understanding of the formation and evolution of exoplanets. It will also carry out in-depth studies of the cosmic web and early galaxies, and constrain the nature of the dark matter and dark energy. We describe briefly the primary scientific motivations and main technical considerations based on our preliminary simulation results. We find that a monolithic off-axis space telescope with a primary mirror diameter larger than 6m equipped with a high contrast chronograph can identify water in the atmosphere of a habitable-zone Earth-like planet around a Sun-like star.Comment: 15 pages, 5 figures, accepted for publication in RAA and is available onlin

Controlled released naringin-loaded liposome/sucrose acetate isobutyrate hybrid depot for osteogenesis in vitro and in vivo

Introduction: A common problem in bone tissue engineering is that the burst release of active osteogenic factors is not beneficial for osteogenesis. This study aimed to prepare naringin (Ng) liposomes to reduce the burst release of Ng and improve new bone formation.Methods: We synthesized Ng liposomes using the thin-film hydration method. Drug-encapsulation efficacy experiments were conducted using the ultracentrifugation technique. The morphology and size distributions of freezedried liposomes were determined by transmission electron microscopy and dynamic light scattering. The Ng liposomes and Ng-lipo/sucrose acetate isobutyrate (SAIB) depots were characterized using Fourier transform infrared spectroscopy and in vitro release studies. After implantation of the Ng-lipo/SAIB depots, in vitro osteoblast-liposome interactions and in vivo osteogenesis were tested.Results: The formulation of freeze-dried Ng liposomes via an optimized recipe yielded nanosized (136.9 nm) negatively charged particles with a high encapsulation efficiency (~76.3%). Their chemical structure did not change after adding SAIB to the Ng liposomes. The burst release was reduced dramatically from 74.4% to 23.7%. In vivo, after 8 weeks, the new bone formation rate in the calvarial defects of Sprague-Dawley rats receiving Ng-lipo/SAIB was 57% compared with 25.18% in the control group (p = .0003).Discussion: Our results suggested that Ng-lipo/SAIB hybrid depots could serve as candidate materials for drug delivery in bone regeneration applications

Production, characterization, and epitope mapping of a monoclonal antibody against genotype VII Newcastle disease virus V protein

Newcastle disease virus (NDV) V protein is crucial for viral interferon (IFN) antagonism and virulence, determining its host range restriction. However, little information is available on the B cell epitopes of V protein and the subcellular movement of V protein in the process of NDV infection. In this study, the monoclonal antibody (mAb) clone 3D7 against genotype VII NDV V protein was generated by immunizing mice with a purified recombinant His-tagged carboxyl-terminal domain (CTD) region of V protein. Fine epitope mapping analysis and B-cell epitope prediction indicated that mAb 3D7 recognized a linear epitope 152RGPAELWK159, which is located in the V protein CTD region. Sequence alignment showed that the mAb clone 3D7-recognized epitope is highly conserved among Class II genotype VII NDV strains, but not among other genotypes, suggesting it could serve as a genetic marker to differentiate NDV genotypes. Furthermore, the movement of V protein during NDV replication in infected cells were determined by using this mAb. It was found that V protein localized around the nucleus during virus replication. The establishment of V protein-specific mAb and identification of its epitope extend our understanding of the antigenic characteristics of V protein and provide a basis for the development of epitope-based diagnostic assays

Magnetic Resonance Imaging of Bone Marrow Cell-Mediated Interleukin-10 Gene Therapy of Atherosclerosis

A characteristic feature of atherosclerosis is its diffuse involvement of arteries across the entire human body. Bone marrow cells (BMC) can be simultaneously transferred with therapeutic genes and magnetic resonance (MR) contrast agents prior to their transplantation. Via systemic transplantation, these dual-transferred BMCs can circulate through the entire body and thus function as vehicles to carry genes/contrast agents to multiple atherosclerosis. This study was to evaluate the feasibility of using in vivo MR imaging (MRI) to monitor BMC-mediated interleukin-10 (IL-10) gene therapy of atherosclerosis.For in vitro confirmation, donor mouse BMCs were transduced by IL-10/lentivirus, and then labeled with a T2-MR contrast agent (Feridex). For in vivo validation, atherosclerotic apoE(-/-) mice were intravenously transplanted with IL-10/Feridex-BMCs (Group I, n = 5) and Feridex-BMCs (Group II, n = 5), compared to controls without BMC transplantation (Group III, n = 5). The cell migration to aortic atherosclerotic lesions was monitored in vivo using 3.0T MRI with subsequent histology correlation. To evaluate the therapeutic effect of BMC-mediated IL-10 gene therapy, we statistically compared the normalized wall indexes (NWI) of ascending aortas amongst different mouse groups with various treatments.Of in vitro experiments, simultaneous IL-10 transduction and Feridex labeling of BMCs were successfully achieved, with high cell viability and cell labeling efficiency, as well as IL-10 expression efficiency (≥90%). Of in vivo experiments, MRI of animal groups I and II showed signal voids within the aortic walls due to Feridex-created artifacts from the migrated BMCs in the atherosclerotic plaques, which were confirmed by histology. Histological quantification showed that the mean NWI of group I was significantly lower than those of group II and group III (P<0.05).This study has confirmed the possibility of using MRI to track, in vivo, IL-10/Feridex-BMCs recruited to atherosclerotic lesions, where IL-10 genes function to prevent the progression of atherosclerosis