New lasiodiplodins from mangrove endophytic fungus <i>Lasiodiplodia</i> sp. 318^#

<p>Two new lasiodiplodins (<b>1</b>–<b>2</b>) together with three known analogues, were isolated from a mangrove endophytic fungus, <i>Lasiodiplodia</i> sp. 318^#. Their structures were established by spectroscopic techniques (1D- and 2D-NMR, HR-ESI-MS, etc.), and electronic circular dichroism. Cytotoxic activities of compounds <b>1</b>–<b>5</b> were evaluated <i>in vitro</i>. Compound <b>4</b> was the most potent, with IC₅₀ values of 5.29 μM against MMQ, 13.05 μM against GH3. Preliminary structural-activity analysis indicated that the functional group (resorcinol-3-OH) contributed greatly to the binding of Lasiodiplodins to the cytotoxic activities.</p