Influence of Indentation on the Fatigue Strength of Carbonitrided Plain Steel

To study the influence of indentation on the fatigue strength of untreated and carbonitrided specimens of S38C steel, the fatigue limit of specimens with and without indentations was tested. Fracture surfaces were observed using scanning electron microscopy (SEM). The results show that the fatigue strength of the untreated specimen decreases with increasing dimension of indentation, without significant difference compared to the predicted results. Compared to the fatigue limit of the untreated specimen, those of the carbonitrided specimen and the carbonitrided specimen whose compound layer was polished were improved by 12% and 40%, respectively. The fatigue strength of the carbonitrided specimen decreased sharply with increasing indentation size because of the presence of microcracks in the compound layer. When the compound layer was removed, the fatigue limit was observed to be less sensitive to indentation than that of the carbonitrided specimen

Research on Secure Localization Model Based on Trust Valuation in Wireless Sensor Networks

Secure localization has become very important in wireless sensor networks. However, the conventional secure localization algorithms used in wireless sensor networks cannot deal with internal attacks and cannot identify malicious nodes. In this paper, a localization based on trust valuation, which can overcome a various attack types, such as spoofing attacks and Sybil attacks, is presented. The trust valuation is obtained via selection of the property set, which includes estimated distance, localization performance, position information of beacon nodes, and transmission time, and discussion of the threshold in the property set. In addition, the robustness of the proposed model is verified by analysis of attack intensity, localization error, and trust relationship for three typical scenes. The experimental results have shown that the proposed model is superior to the traditional secure localization models in terms of malicious nodes identification and performance improvement

Giant Brunner’s gland adenoma of the duodenum complicated with bleeding: a case report

Brunner’s gland adenoma（BGA） of the duodenum is an extremely rare benign tumor in clinical practice. In this article， the diagnosis and treatment of one case of BGA of the duodenum were reported. The patient had a history of anemia for 4 years， but she never received tests to identify the cause. She was admitted to Department of Neurology for the first time due to dizziness， and was transferred to our department due to gastrointestinal bleeding during hospitalization. Hemorrhagic shock and transient syncope occurred during treatment， which were alleviated after drug therapy. Then， gastroscopy was immediately performed and showed protrusion lesions in the descending duodenum. The diagnosis of BGA was finally confirmed by endoscopic pathological resection. This article aiming to deepen the gastroenterologists / endoscopists’ understanding of BGA and improve the diagnostic and therapeutic levels

Optical thermal filters for eXTP: Manufacturing and characterization

In order to ensure the effective detection of X-ray astronomical detectors by blocking ultraviolet, visible and infrared light, adding optical thermal filter in front of the load is an effective method. According to the scientific requirements of eXTP, optical thermal filters with aluminized polyimide (PI) film structure had been designed and tested in this paper, the results of mechanical tests including burst pressure, vibration and acoustic tests, also the transparent properties of optics in UV, Vis and IR lights are presented. The mechanical test results show that the filters for LAD and SFA can't pass the acoustic tests, causing the thickness of PI should be increased or a nickel mesh structure should be added. Furthermore, the transmission test results indicate that a single-sided Al deposited structure is more suitable than a double-sided one

Embryonic diapause due to high glucose is related to changes in glycolysis and oxidative phosphorylation, as well as abnormalities in the TCA cycle and amino acid metabolism

IntroductionThe adverse effects of high glucose on embryos can be traced to the preimplantation stage. This study aimed to observe the effect of high glucose on early-stage embryos. Methods and resultsSeven-week-old ICR female mice were superovulated and mated, and the zygotes were collected. The zygotes were randomly cultured in 5 different glucose concentrations (control, 20mM, 40mM, 60mM and 80mM glucose). The cleavage rate, blastocyst rate and total cell number of blastocyst were used to assess the embryo quality. 40 mM glucose was selected to model high glucose levels in this study. 40mM glucose arrested early embryonic development, and the blastocyst rate and total cell number of the blastocyst decreased significantly as glucose concentration was increased. The reduction in the total cell number of blastocysts in the high glucose group was attributed to decreased proliferation and increased cell apoptosis, which is associated with the diminished expression of GLUTs (GLUT1, GLUT2, GLUT3). Furthermore, the metabolic characterization of blastocyst culture was observed in the high-glucose environment. DiscussionThe balance of glycolysis and oxidative phosphorylation at the blastocyst stage was disrupted. And embryo development arrest due to high glucose is associated with changes in glycolysis and oxidative phosphorylation, as well as abnormalities in the TCA cycle and amino acid metabolism

Functionalizing tetraphenylpyrazine with perylene diimides (PDIs) as high-performance nonfullerene acceptors

Perylene diimide (PDI)-based small molecular acceptors with a three-dimensional structure are thought to be essential for efficient photocurrent generation and high power conversion efficiencies (PCEs). Herein, a couple of new perylene diimide acceptors (PPDI-O and PPDI-Se) have been designed and successfully synthesized using pyrazine as the core-flanking pyran and selenophene-fused PDIs, respectively. Compared to PPDI-O, PPDI-Se exhibits a blue-shifted absorption in the 400–600 nm range, a comparable LUMO level, and a more distorted molecular geometry. The PPDI-Se-based organic solar cell device with PDBT-T1 as the donor achieved the highest PCE of 7.47% and a high open-circuit voltage (Voc) of up to 1.05 V. The high photovoltaic performance of PPDI-Se-based devices can be attributed to its high LUMO energy level, complementary absorption spectra with donor materials, favorable morphology and balanced carrier transport. The results demonstrate the potential of this type of fullerene-free acceptor for high efficiency organic solar cells

Identification of a BET Family Bromodomain/Casein Kinase II/TAF-Containing Complex as a Regulator of Mitotic Condensin Function

SummaryCondensin is a central regulator of mitotic genome structure with mutants showing poorly condensed chromosomes and profound segregation defects. Here, we identify NCT, a complex comprising the Nrc1 BET-family tandem bromodomain protein (SPAC631.02), casein kinase II (CKII), and several TAFs, as a regulator of condensin function. We show that NCT and condensin bind similar genomic regions but only briefly colocalize during the periods of chromosome condensation and decondensation. This pattern of NCT binding at the core centromere, the region of maximal condensin enrichment, tracks the abundance of acetylated histone H4, as regulated by the Hat1-Mis16 acetyltransferase complex and recognized by the first Nrc1 bromodomain. Strikingly, mutants in NCT or Hat1-Mis16 restore the formation of segregation-competent chromosomes in cells containing defective condensin. These results are consistent with a model where NCT targets CKII to chromatin in a cell-cycle-directed manner in order to modulate the activity of condensin during chromosome condensation and decondensation

The large area detector onboard the eXTP mission

The Large Area Detector (LAD) is the high-throughput, spectral-timing instrument onboard the eXTP mission, a flagship mission of the Chinese Academy of Sciences and the China National Space Administration, with a large European participation coordinated by Italy and Spain. The eXTP mission is currently performing its phase B study, with a target launch at the end-2027. The eXTP scientific payload includes four instruments (SFA, PFA, LAD and WFM) offering unprecedented simultaneous wide-band X-ray timing and polarimetry sensitivity. The LAD instrument is based on the design originally proposed for the LOFT mission. It envisages a deployed 3.2 m2 effective area in the 2-30 keV energy range, achieved through the technology of the large-area Silicon Drift Detectors - offering a spectral resolution of up to 200 eV FWHM at 6 keV - and of capillary plate collimators - limiting the field of view to about 1 degree. In this paper we will provide an overview of the LAD instrument design, its current status of development and anticipated performance