sj-pdf-3-imr-10.1177_03000605221133655 - Supplemental material for Prediction of homologous recombination deficiency from cancer gene expression data

Supplemental material, sj-pdf-3-imr-10.1177_03000605221133655 for Prediction of homologous recombination deficiency from cancer gene expression data by Jun Kang, Jieun Lee, Ahwon Lee and Youn Soo Lee in Journal of International Medical Research</p

sj-pdf-4-imr-10.1177_03000605221133655 - Supplemental material for Prediction of homologous recombination deficiency from cancer gene expression data

Supplemental material, sj-pdf-4-imr-10.1177_03000605221133655 for Prediction of homologous recombination deficiency from cancer gene expression data by Jun Kang, Jieun Lee, Ahwon Lee and Youn Soo Lee in Journal of International Medical Research</p

sj-pdf-1-imr-10.1177_03000605221133655 - Supplemental material for Prediction of homologous recombination deficiency from cancer gene expression data

Supplemental material, sj-pdf-1-imr-10.1177_03000605221133655 for Prediction of homologous recombination deficiency from cancer gene expression data by Jun Kang, Jieun Lee, Ahwon Lee and Youn Soo Lee in Journal of International Medical Research</p

sj-pdf-2-imr-10.1177_03000605221133655 - Supplemental material for Prediction of homologous recombination deficiency from cancer gene expression data

Supplemental material, sj-pdf-2-imr-10.1177_03000605221133655 for Prediction of homologous recombination deficiency from cancer gene expression data by Jun Kang, Jieun Lee, Ahwon Lee and Youn Soo Lee in Journal of International Medical Research</p

Role and Effect of Anions in the Construction of Silver Complexes Based on a Pyridylimidazole Ligand with L‑Type Coordination Vectors and Their Photoluminescence Properties

Three anion-dependent Ag­(I) coordination complexesspecifically, [Ag₂(pyim)₂­(NO₃)₂] (<b>1</b>), {[Ag­(pyim)₂]­·ClO₄·CH₃OH­·(H₂O)_1.25}_<i>n</i> (<b>2</b>), and [Ag₄(pyim)₄]­·(CF₃SO₃)₄ (<b>3</b>)were prepared by the reaction of the corresponding silver salts with a rigid ditopic <i>N</i>-terphenyl-substituted 2-(4-pyridyl)­imidazole (pyim) ligand possessing an “L”-type coordination vector. Complex <b>1</b>, in which the nitrate anion acts as a monodentate terminal ligand, exhibits a discrete cyclic dimer structure, whereas complex <b>2</b>, incorporating a perchlorate anion with weak coordination ability, displays an anion-free one-dimensional (1D) looped chain structure resulting from the Ag sharing of consecutive cyclic dimers. When using a trifluoromethanesulfonate (triflate) as a counteranion with moderate affinity toward the metal center, the resulting complex <b>3</b> exhibits an unusual cyclic tetramer structure. In <b>3</b>, the triflate anions act as bridges between adjacent cyclic tetramers via the weak interaction with the Ag­(I) ions, yielding a parquet-like two-dimensional (2D) framework. All three complexes display violet-blue emission, with maxima ranging from 388 to 396 nm. Furthermore, in solution, complex <b>2</b> exhibits a substantial emission enhancement, resulting in an emission intensity nearly 2 orders of magnitude greater than those of both the free ligand and the two other Ag­(I) complexes, <b>1</b> and <b>3</b>. Counteranions possessing different abilities to coordinate to Ag­(I) play important roles in the structural diversity and photoluminescence properties of <b>1</b>–<b>3</b>

Inverted Quantum-Dot Light Emitting Diode Using Solution Processed <i>p</i>‑Type WO_<i>x</i> Doped PEDOT:PSS and Li Doped ZnO Charge Generation Layer

Quantum dots (QDs) are a promising material for emissive display with low-cost manufacturing and excellent color purity. In this study, we report colloidal quantum-dot light emitting diodes (QLEDs) with an inverted architecture with a solution processed charge generation layer (CGL) of <i>p</i>-type polymer (tungsten oxide doped poly­(ethylenedioxythiophene)/polystyrenesulfonate, PEDOT:PSS:WO_<i>x</i>) and <i>n</i>-type metal oxide (lithium doped zinc oxide, LZO). The effective charge generation in solution processed <i>p</i>–<i>n</i> junction was confirmed by capacitance–voltage (<i>C</i>–<i>V</i>) and current density–electric field characteristics. It is also demonstrated that the performances of CGL based QLEDs are very similar when various substrates with different work functions are used

Previous studies of XP regimen in metastatic breast cancer patients previously treated with anthracycline and taxane.

<p>Previous studies of XP regimen in metastatic breast cancer patients previously treated with anthracycline and taxane.</p

Capecitabine and cisplatin (XP) combination systemic chemotherapy in heavily pre-treated HER2 negative metastatic breast cancer - Fig 1

<p>The median progression free survival (A) and overall survival (B) in total patient population.</p

High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men

<div><p>We performed a follow-up study to address whether high sensitivity C-reactive protein (hs-CRP) levels within the normal range can predict the development of non-alcoholic fatty liver disease (NAFLD) in healthy male subjects. Among15347 male workers between 30 and 59 years old who received annual health check-ups in 2002, a NAFLD-free cohort of 4,138 was followed through December 2009. Alcohol consumption was assessed with a questionnaire. At each visit, abdominal ultrasonography was performed to identify fatty liver disease. The COX proportional hazard model was used to evaluate the relationship between hs-CRP and incident NAFLD. During the follow-up period, 28.8% (1191 of 4138) of participants developed NAFLD. The hazard ratios of NAFLD were increased by hs-CRP categories within the normal range in the non-adjusted model and age-adjusted model. After adjusting for age, exercise, smoking, BMI, systolic BP, triglyceride, and fasting glucose, these incidences were only increased between the lowest and the highest hs-CRP categories. The risk for NAFLD increased as the hs-CRP level increased (p< 0.001). As the hs-CRP level increased within the healthy cohort, the risk of developing NAFLD increased. This trend remained true even if the hs-CRP level remained within the normal range. hs-CRP can be used as a predictor of NAFLD, as well as other obesity-associated diseases. Therefore, individuals with higher hs-CRP levels (even within the normal range) may require appropriate follow-up and management to prevent NAFLD development.</p></div

The Preparation of BN-Doped Atomic Layer Graphene via Plasma Treatment and Thermal Annealing

We report a new method for the codoping of boron and nitrogen in a monolayer graphene film. After the CVD synthesis of monolayer graphene, BN-doped graphene is prepared by performing power-controlled plasma treatment and thermal annealing with borazine. BN-doped graphene films with various doping levels, which were controlled by altering the plasma treatment power, were found with Raman and electrical measurements to investigate exhibit p-doping behavior. Transmission electron microscopy, electron energy loss spectroscopy, and X-ray photoelectron spectroscopy were used to demonstrate that the synthesized BN-doped graphene films have a sp² hybridized hexagonal structure. This approach to tuning the distribution and doping levels of boron and nitrogen in monolayer sp² hybridized BN-doped graphene is expected to be very useful for applications requiring large-area graphene with an opened band gap