The Type II alveolar epithelial cells from the PQ group (×8000).

<p>The nuclei were collapsed and contained dense heterochromatin; the endoplasmic reticulum tended to be vesiculated, the basement membranes were absent or disrupted, the mitochondria was vacuolated and the number of lamellar bodies clearly decreased.</p

HE stain of PQ group (×200).

<p>The inflammatory process with marked infiltration of leukocytes into interstitial and alveolar spaces, edema, alveolar distortion, and thickening of the alveolar wall.</p

Dynamic change of HYP in the lungs of the three groups (mean±SD, µg/mg).

<p>Dynamic change of HYP in the lungs of the three groups (mean±SD, µg/mg).</p

HE stain of control group (×200).

<p>Lung tissue is normal. The alveolar space has a normal interstitium structure and no effusion.</p

HE stain of bosentan group (×200).

<p>The damage is improved more than that of the PQ group, and less inflammatory cell infiltration were found in the interstitial lung and alveoli, interstitial edema and alveolar hemorrhage were ameliorated.</p

Masson stain of PQ group (×200).

<p>The alveolar wall was significantly thickened, there was evidence of phoroblast hyperplasia and fibroglia fibrils, which were obviously hyperplastic.</p

Dynamic change of TGF-β1 in serum from the three groups (mean±SD, ng/L).

<p>Dynamic change of TGF-β1 in serum from the three groups (mean±SD, ng/L).</p

Masson stain of control group (×200).

<p>Lung tissue is normal. The alveolar space has a normal interstitium structure, and no effusion.</p

Dynamic change of ET-1 in the serum from the three groups (mean±SD, ng/L).

<p>Dynamic change of ET-1 in the serum from the three groups (mean±SD, ng/L).</p

Dynamic change of TGF-β1 in the lungs of the three groups (mean±SD, ng/L).

<p>Dynamic change of TGF-β1 in the lungs of the three groups (mean±SD, ng/L).</p