Converting ECG Signals to Images for Efficient Image-text Retrieval via Encoding

Automated interpretation of electrocardiograms (ECG) has garnered significant attention with the advancements in machine learning methodologies. Despite the growing interest in automated ECG interpretation using machine learning, most current studies focus solely on classification or regression tasks and overlook a crucial aspect of clinical cardio-disease diagnosis: the diagnostic report generated by experienced human clinicians. In this paper, we introduce a novel approach to ECG interpretation, leveraging recent breakthroughs in Large Language Models (LLMs) and Vision-Transformer (ViT) models. Rather than treating ECG diagnosis as a classification or regression task, we propose an alternative method of automatically identifying the most similar clinical cases based on the input ECG data. Also, since interpreting ECG as images are more affordable and accessible, we process ECG as encoded images and adopt a vision-language learning paradigm to jointly learn vision-language alignment between encoded ECG images and ECG diagnosis reports. Encoding ECG into images can result in an efficient ECG retrieval system, which will be highly practical and useful in clinical applications. More importantly, our findings could serve as a crucial resource for providing diagnostic services in regions where only paper-printed ECG images are accessible due to past underdevelopment.Comment: 26 page

Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17

This study was conducted to explore the effects of interferon tau (IFNT) on the intestinal microbiota and expression of interleukin 17 (IL-17) in the intestine of mice. IFNT supplementation increased microbial diversity in the jejunum and ileum but decreased microbial diversity in the feces. IFNT supplementation influenced the composition of the intestinal microbiota as follows: (1) decreasing the percentage of Firmicutes and increasing Bacteroidetes in the jejunum and ileum; (2) enhancing the percentage of Firmicutes but decreasing Bacteroidetes in the colon and feces; (3) decreasing Lactobacillus in the jejunum and ileum; (4) increasing the percentage of Blautia, Bacteroides, Alloprevotella, and Lactobacillus in the colon; and (5) increasing the percentage of Lactobacillus, Bacteroides, and Allobaculum, while decreasing Blautia in the feces. Also, IFNT supplementation decreased the expression of IL-17 in the intestines of normal mice and of an intestinal pathogen infected mice. In conclusion, IFNT supplementation modulates the intestinal microbiota and intestinal IL-17 expression, indicating the applicability of IFNT to treat the intestinal diseases involving IL-17 expression and microbiota

Variant Near FGF5 Has Stronger Effects on Blood Pressure in Chinese With a Higher Body Mass Index

The objective of this study was to investigate the genetic association of 4 candidate variants with blood pressure and test the modifying effects of environmental factors including age, sex, and body mass index (BMI)

Risk Sharing of Urban Underground Comprehensive Pipe Gallery PPP Project Based on Grey Relational Analysis

In order to establish a reasonable, effective and accurate risk sharing mechanism for PPP project of urban underground comprehensive pipe gallery, 25 risk factors are identified by the work structure decomposition method. Secondly, a risk sharing method based on improved grey correlation analysis is proposed to solve the complexity of risk sharing in PPP project of urban underground comprehensive pipe gallery. Then, an improved risk sharing model is constructed based on this method. Finally, some targeted measures are proposed for the identified key risk factors. This risk sharing model has certain reference value for the research on risk sharing of urban underground comprehensive pipeline corridor PPP projects

Self-assembly of polymer-coated plasmonic nanocrystals : from synthetic approaches to practical applications

Self-assembly of plasmonic nanocrystals (PNCs) and polymers provides access to a variety of functionalized metallic-polymer building blocks and higher-order hybrid plasmonic assemblies, and thus is of considerable fundamental and practical interest. The hybrid assemblies often not only inherit individual characteristics of polymers and PNCs but also exhibit distinct photophysical and catalytic properties compared to that of a single PNC building block. The tailorable plasmonic coupling between PNCs within assemblies enables the precise control over localized surface plasmon resonance, which subsequently affords a series of light-driven or photo-activated applications, such as surface-enhanced Raman scattering detection, photoacoustic imaging, photothermal therapy, and photodynamic therapy. In this review, the synthetic strategies of a library of PNC-polymer hybrid building blocks and corresponding assemblies are summarized along with the mechanisms of polymer-assisted self-assembly of PNCs and the concepts for bridging the intrinsic properties of PNC-polymer assemblies to widespread practical applications.MOE (Min. of Education, S’pore

Antibiofilm activity of gallium(III) complexed anionic polymers in combination with antibiotics

Pseudomonas aeruginosa (P. aeruginosa) is a life-threatening pathogen associated with multiantibiotic resistance, which is largely caused by its strong ability to form biofilms. Recent research has revealed that gallium (III) shows an activity against the biofilm of P. aeruginosa by interfering with Fe metabolism. The antibacterial activity of the combination of Ga3+ ion and antibiotic rifampicin (RMP) against P. aeruginosa PAO1 is investigated. An anionic polymer poly{{2-[(2-methylprop-2-enoyl)oxy]ethyl}phosphonic acid} (PDMPOH) is exploited to form complexes (GaPD) with Ga3+ . The GaPD complexes act as a carrier of Ga3+ and release Ga3+ via enzymatic degradation by bacterial lipases. GaPD is found to damage the outer membrane, leading to enhanced cellular uptake of RMP and Ga3+ due to increased outer membrane permeability, which inhibits the RNA polymerase and interferes with Fe metabolism. The antibiofilm activity and biocompatibility of the GaPD system offer a promising treatment option for P. aeruginosa biofilm-related infections.Ministry of Education (MOE)This work was financially supported by Ministry of Education, Singapore (RG45/18, MOE2018-T3-1-003, MOE2018-T2-2-128, and MOE2013-T3-1-002)

Caging cationic polymer brush-coated plasmonic nanostructures for traceable selective antimicrobial activities

Cationic polymers are under intense research to achieve prominent antimicrobial activity. However, the cellular and in vivo toxicity caused by nonspecific electrostatic interaction has become a major challenge for their practical applications. Here, the development of a "caging" strategy based on the use of a block copolymer consisting of a stealth block and an anionic block that undergoes degradation in presence of enzymes secreted by selective bacterial pathogens of interest is reported. The results have shown that antimicrobial cationic polymer brushes-coated gold nanorods (AuNRs) can be caged by the block polymer of poly(ethylene glycol) and anionic, lipase-degradable block of ε-caprolactone and methacrylic acid copolymer to afford neutrally charged surfaces. The caged AuNRs are activated by lipase released by bacteria of interest to endow an excellent bactericidal effect but show minimal binding and toxicity against mammalian cells and nonspecific bacteria that do not produce lipase. In this design, AuNRs play multifunctional roles as the scaffolds for polymer brushes, photothermal transducers, and imaging probes for traceable delivery of the activation and delivery of bactericidal cationic polymer brushes. The caging strategy opens new opportunities for the safe delivery of antimicrobial materials for the treatment of bacterial infections.Ministry of Education (MOE)The authors acknowledgethe financial support from Singapore Ministry of Education (MOE2018-T3-1-003 and RG49/16)

Pore Structure Multifractal Characteristics of Coal Reservoirs in the Central and Eastern Qinshui Basin and Influencing Factors

The heterogeneity of the pore structure of coal reservoirs affects the desorption and diffusion characteristics of coalbed methane, and determining its distribution law is conducive to improving the theory of coalbed methane development. The central and eastern parts of the Qinshui Basin are rich in coalbed methane resources, but the heterogeneity characteristics of the pore structure of coal reservoirs are not clear. NMR has the advantages of being fast, non-destructive and full-scale, and multifractal can describe the self-similarity of NMR T2 curve at different scales so as to analyze the complexity of pore distribution. Based on this, 15 samples with different coal ranks were collected from the central and eastern Qinshui Basin (Ro,max between 1.54 and 2.78%), and quantitative pore characterization experiments such as low-field nuclear magnetic resonance (LF-NMR) and low-temperature liquid nitrogen adsorption (LTN2A) were conducted. Based on multifractal theory, the heterogeneity law of pore structure was quantitatively evaluated, and its influencing factors were elucidated. The results showed that the BJH pore volume of coal samples in the study area ranged from 0.0005–0.0028 cm3/g, with an average of 0.0014 cm3/g, and the BET specific surface area was 0.07–2.52 m2/g, with an average of 0.41 m2/g. The NMR T2 spectrum peaked at 0.1–1, 10–100 and 100–1000 ms, and the spectrum was mostly bimodal or trimodal, indicating that pores of different pore sizes were developed. There were great differences in the pore structure of different coal ranks; high-rank coal was dominated by micropores, and the proportion of mesopores and macropores of medium-rank coal was higher. The pore structure of coal samples showed obvious multifractal characteristics, and the fractal characteristics of the sparse region (low-value information) were more significant; they dominated the pore distribution and had a stronger influence on the distribution of pore space. Pore structure heterogeneity is closely related to the degree of coalification, and with the increase in coalification, it is closely related to coal lithotype and quality, and high mineral and inertinite contents lead to the enhancement of pore structure heterogeneity in coal reservoirs, while Ro,max, Mad and vitrinite group contents have opposite effects. The research results provide theoretical guidance for the subsequent exploration and development of coalbed methane in the region

Dietary l-Arginine Supplementation Protects Weanling Pigs from Deoxynivalenol-Induced Toxicity

This study was conducted to determine the positive effects of dietary supplementation with l-arginine (Arg) on piglets fed a deoxynivalenol (DON)-contaminated diet. A total of eighteen, 28-day-old healthy weanling pigs were randomly assigned into one of three groups: uncontaminated basal diet (control group), 6 mg/kg DON-contaminated diet (DON group) and 6 mg/kg DON + 1% l-arginine (DON + ARG group). After 21 days of Arg supplementation, piglets in the DON and DON + ARG groups were challenged by feeding 6 mg/kg DON-contaminated diet for seven days. The results showed that DON resulted in damage to piglets. However, clinical parameters, including jejunal morphology, amino acid concentrations in the serum, jejunum and ileum, were improved by Arg (p < 0.05). Furthermore, the mRNA levels for sodium-glucose transporter-1 (SGLT-1), glucose transporter type-2 (GLUT-2) and y+l-type amino acid transporter-1 (y+LAT-1) were downregulated in the DON group, but the values were increased in the DON + ARG group (p < 0.05). Collectively, these results indicate that dietary supplementation with Arg exerts a protective role in pigs fed DON-contaminated diets