Cu-Catalyzed Aminodifluoroalkylation of Alkynes and α‑Bromodifluoroacetamides

The copper-catalyzed highly regioselective aminodifluoroalkylation of alkynes and α-bromodifluoroacetamides was realized for the first time. With this method, 3,3-difluoro-1<i>H</i>-pyrrol-2­(3<i>H</i>)-ones were constructed in a single step from various alkynes and α-bromodifluoroacetamides substrates without using any extra oxidant