1 research outputs found
Polymethoxyflavone–Enriched Fraction from Ougan (Citrus reticulata cv. Suavissima) Attenuated Diabetes and Modulated Gut Microbiota in Diabetic KK‑A<sup>y</sup> Mice
Diabetes mellitus is a serious, chronic disease worldwide;
yet
it is largely preventable through physical activity and healthy diets.
Ougan (Citrus reticulata cv. Suavissima) is a characteristic citrus variety rich
in polymethoxyflavones. In the present study, the anti-diabetic effects
of the polymethoxyflavone-enriched fraction from Ougan (OG-PMFs) were
investigated. Diabetic KK-Ay mice were supplemented with
different doses of OG-PMFs for 5 weeks. Our results demonstrated that
OG-PMFs exhibited robust protective effects against diabetes symptoms
in KK-Ay mice. The potential mechanisms may partially be
attributed to the restoration of hepatic GLUT2 and catalase expression.
Notably, OG-PMF administration significantly altered the gut microbiota
composition in diabetic KK-Ay, indicated by the suppression
of metabolic disease-associated genera Desulfovibrio, Lachnoclostridium, Enterorhabdus, and Ralstonia, implying that the gut microbiota might be another target for OG-PMFs
to show effects. Taken together, our results provided a supplementation
for the metabolic-protective effects of PMFs and highlighted that
OG-PMFs hold great potential to be developed as a functional food
ingredient