1,2-Bis(4-nitro­benzo­yl)hydrazine

The title mol­ecule, C14H10N4O6, crystallizes with one half-mol­ecule in the asymmetric unit; the mid-point of the N—N bond lies on an inversion centre. The nitro and amide groups are twisted with respect to the benzene ring, making dihedral angles of 14.6 (5) and 31.1 (5)°, respectively. In the crystal structure, mol­ecules are linked through N—H⋯O hydrogen bonding between the imino and carbonyl groups

Repurposing Metformin for Lung Cancer Management

In this article, we introduced the background knowledge of lung cancer management and considered repurposing old drugs to overcome therapy bottleneck. We chose metformin to prove both its antihyperglycemia and antitumor formation effects. Based on the metformin-related AMPK-dependent pathway, we tried to explore the AMPK-independent pathway in inhibition of lung tumorigenesis by metformin. Using preclinical data mining from clinical settings with a literature review, we attempted to clarify the role of metformin in lung cancer management. Additional objective and strong evidence are needed using randomized control studies to verify the benefit of metformin in clinical practice. Furthermore, we proposed two lung cancer animal models and showed the establishment processes thoroughly. We hope that these two lung cancer animal models provide a useful platform for furthering old drug repurposing as well as new drug investigations in the future

Non-life insurance price dynamics: evidence from the Chinese insurance market

Non-life insurance prices may fluctuate due to economic and/or institutional factors; occasionally, the changes are cyclical. While the majority of previous studies relating to insurance price dynamics adopt data from developed economies, this paper uses data from China to provide new evidence. This study tests the long-term and short-term effects of real gross domestic product (GDP), interest rate and rate of stock market return on the prices of different lines of non-life insurance, i.e., property-liability insurance and personal accident insurance. The results indicate that the price dynamics of property-liability insurance are generally similar to those of developed countries, except for the effect of GDP, while price determination of personal accident insurance seems to be affected by a wider range of economic and institutional variables and has its own features. The price dynamics of non-life insurance in China have been identified as being connected to the country-specific economic and institutional environments

(E)-3-(4-Chloro­phen­yl)-1-(5-hy­droxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one

There are two independent mol­ecules in the asymmetric unit of the title compound, C20H17ClO3, each having an E configuration about the –C=C– bond. The dihedral angles between the two benzene rings in the two mol­ecules are 7.17 (11) and 9.82 (11)°. In both mol­ecules, the hy­droxy group is involved in an intra­molecular O—H⋯O hydrogen bond

Scale-invariance of human EEG signals in sleep

We investigate the dynamical properties of electroencephalogram (EEG) signals of human in sleep. By using a modified random walk method, We demonstrate that the scale-invariance is embedded in EEG signals after a detrending procedure. Further more, we study the dynamical evolution of probability density function (PDF) of the detrended EEG signals by nonextensive statistical modeling. It displays scale-independent property, which is markedly different from the turbulent-like scale-dependent PDF evolution.Comment: 4 pages and 6 figure