SNP set analysis for detecting disease association using exon sequence data

Rare variants are believed to play an important role in disease etiology. Recent advances in high-throughput sequencing technology enable investigators to systematically characterize the genetic effects of both common and rare variants. We introduce several approaches that simultaneously test the effects of common and rare variants within a single-nucleotide polymorphism (SNP) set based on logistic regression models and logistic kernel machine models. Gene-environment interactions and SNP-SNP interactions are also considered in some of these models. We illustrate the performance of these methods using the unrelated individuals data from Genetic Analysis Workshop 17. Three true disease genes (FLT1, PIK3C3, and KDR) were consistently selected using the proposed methods. In addition, compared to logistic regression models, the logistic kernel machine models were more powerful, presumably because they reduced the effective number of parameters through regularization. Our results also suggest that a screening step is effective in decreasing the number of false-positive findings, which is often a big concern for association studies

The 5th International Workshop on Social Web for Disaster Management (SWDM'18): Collective Sensing, Trust, and Resilience in Global Crises

During large-scale emergencies such as natural and man-made disasters, a massive amount of information is posted by the public in social media. Collecting, aggregating, and presenting this information to stakeholders can be extremely challenging, particularly if an understanding of the “big picture” is sought. This international workshop, the fifth in the series, is a key venue for researchers and practitioners to discuss research challenges and technical issues around the usage of social media in disaster management