24 research outputs found
Embracing Uncertainty. Young people on the move in Addis Ababa’s inner city
A note for calculating elasticity. (DOC 57Â kb
sj-docx-2-dhj-10.1177_20552076221131141 - Supplemental material for Global trends and hotspots in research on extended reality in sports: A bibliometric analysis from 2000 to 2021
Supplemental material, sj-docx-2-dhj-10.1177_20552076221131141 for Global trends and hotspots in research on extended reality in sports: A bibliometric analysis from 2000 to 2021 by Jie Zhao, Jie Mao and Jing Tan in Digital Health</p
sj-docx-1-dhj-10.1177_20552076221131141 - Supplemental material for Global trends and hotspots in research on extended reality in sports: A bibliometric analysis from 2000 to 2021
Supplemental material, sj-docx-1-dhj-10.1177_20552076221131141 for Global trends and hotspots in research on extended reality in sports: A bibliometric analysis from 2000 to 2021 by Jie Zhao, Jie Mao and Jing Tan in Digital Health</p
Small Molecule Recognition Triggers Secondary and Tertiary Interactions in DNA Folding and Hammerhead Ribozyme Catalysis
We
have identified tris(2-aminoethyl)amine (tren)-derived
scaffolds with two (t2M) or four (t4M) melamine rings that can target
oligo T/U domains in DNA/RNA. Unstructured T-rich DNAs cooperatively
fold with the tren derivatives to form hairpin-like structures. Both
t2M and t4M act as functional switches in a family of hammerhead ribozymes
deactivated by stem or loop replacement with a U-rich sequence. Catalysis
of bond scission in these hammerhead ribozymes could be restored by
putative t2M/t4M refolding of stem secondary structure or <i>tertiary</i> bridging interactions between loop and stem. The
simplicity of the t2M/t4M binding site enables programming of allostery
in RNAs, recoding oligo-U domains as potential sites for secondary
structure or tertiary contact. In combination with a facile and general
method for installation of the t2M motif on primary amines, the method
described herein streamlines design of synthetic allosteric riboswitches
and small molecule–nucleic acid complexes
Peptide Ligation and RNA Cleavage via an Abiotic Template Interface
We report herein DNA- and RNA-templated
chemical transformation
of bifacial peptide nucleic acid (bPNA) fragments directed by an abiotic
triplex hybrid interface. Assembly of one bPNA strand with two unstructured
oligo T/U strands enables facile insertion of DNA and RNA template
sites within partially folded nucleic acids; this template topology
is not easily accessed through native base-pairing. Triplex hybridization
of reactive bPNA fragments on DNA and RNA templates is shown to catalyze
amide bond ligation and controlled bPNA chain extension. RNA-templated
oxidative coupling of bPNA fragments is found to result in the emergence
of ribozyme cleavage function, thus establishing a connection between
engineered and native reaction sites. These data demonstrate the use
of new topologies in nucleic acid-templated chemistry that could serve
as chemically sensitive DNA and RNA switches
Table_2_Transcatheter arterial chemoembolization of apatinib and camrelizumab (SHR1210) against liver metastasis from hepatic neuroendocrine tumor: a case report.docx
In this case report, we present the case of a 46-year-old woman with a hepatic neuroendocrine tumor (NET G2)-induced liver metastases. Initially, the left lateral lobectomy of the liver was performed. The post-operative pathological examination revealed NET G2, leading to the post-operative recovery with a general review. Further, the re-examination of liver magnetic resonance imaging (MRI) showed post-operative changes in the tumor of the left lateral lobe, with multiple liver masses and possible metastasis. Thus, the liver interventional therapy and apatinib-based targeted therapy based on the “camrelizumab + apatinib” regimen were performed, respectively. The 20-month follow-up indicated a slightly increased hepatic hilum and retroperitoneal lymph nodes, accompanied by hand-foot syndrome. Eventually, the overall condition continued to relieve, indicating that the combined treatment could substantially improve the NET G2 conditions-associated liver metastasis.</p
Table_1_Transcatheter arterial chemoembolization of apatinib and camrelizumab (SHR1210) against liver metastasis from hepatic neuroendocrine tumor: a case report.docx
In this case report, we present the case of a 46-year-old woman with a hepatic neuroendocrine tumor (NET G2)-induced liver metastases. Initially, the left lateral lobectomy of the liver was performed. The post-operative pathological examination revealed NET G2, leading to the post-operative recovery with a general review. Further, the re-examination of liver magnetic resonance imaging (MRI) showed post-operative changes in the tumor of the left lateral lobe, with multiple liver masses and possible metastasis. Thus, the liver interventional therapy and apatinib-based targeted therapy based on the “camrelizumab + apatinib” regimen were performed, respectively. The 20-month follow-up indicated a slightly increased hepatic hilum and retroperitoneal lymph nodes, accompanied by hand-foot syndrome. Eventually, the overall condition continued to relieve, indicating that the combined treatment could substantially improve the NET G2 conditions-associated liver metastasis.</p
Image_2_Transcatheter arterial chemoembolization of apatinib and camrelizumab (SHR1210) against liver metastasis from hepatic neuroendocrine tumor: a case report.tif
In this case report, we present the case of a 46-year-old woman with a hepatic neuroendocrine tumor (NET G2)-induced liver metastases. Initially, the left lateral lobectomy of the liver was performed. The post-operative pathological examination revealed NET G2, leading to the post-operative recovery with a general review. Further, the re-examination of liver magnetic resonance imaging (MRI) showed post-operative changes in the tumor of the left lateral lobe, with multiple liver masses and possible metastasis. Thus, the liver interventional therapy and apatinib-based targeted therapy based on the “camrelizumab + apatinib” regimen were performed, respectively. The 20-month follow-up indicated a slightly increased hepatic hilum and retroperitoneal lymph nodes, accompanied by hand-foot syndrome. Eventually, the overall condition continued to relieve, indicating that the combined treatment could substantially improve the NET G2 conditions-associated liver metastasis.</p
Image_1_Transcatheter arterial chemoembolization of apatinib and camrelizumab (SHR1210) against liver metastasis from hepatic neuroendocrine tumor: a case report.tif
In this case report, we present the case of a 46-year-old woman with a hepatic neuroendocrine tumor (NET G2)-induced liver metastases. Initially, the left lateral lobectomy of the liver was performed. The post-operative pathological examination revealed NET G2, leading to the post-operative recovery with a general review. Further, the re-examination of liver magnetic resonance imaging (MRI) showed post-operative changes in the tumor of the left lateral lobe, with multiple liver masses and possible metastasis. Thus, the liver interventional therapy and apatinib-based targeted therapy based on the “camrelizumab + apatinib” regimen were performed, respectively. The 20-month follow-up indicated a slightly increased hepatic hilum and retroperitoneal lymph nodes, accompanied by hand-foot syndrome. Eventually, the overall condition continued to relieve, indicating that the combined treatment could substantially improve the NET G2 conditions-associated liver metastasis.</p
A Simple Dual-pH Responsive Prodrug-Based Polymeric Micelles for Drug Delivery
To
precisely deliver drug molecules at a targeted site and in a controllable
manner, there has been great interest in designing a synergistical
drug delivery system that can achieve both surface charge-conversion
and controlled release of a drug in response to different stimuli.
Here we outline a simple method to construct an intelligent drug carrier,
which can respond to two different pH values, therefore achieving
charge conversion and chemical-bond-cleavage-induced drug release
in a stepwise fashion. This drug carrier comes from the self-assembly
of a block copolymer-DOX conjugate synthesized through a Schiff base
reaction between poly(2-(diisopropylamino)ethyl methacrylate-<i>b</i>-poly(4-formylphenyl methacrylate-<i>co</i>-polyethylene
glycol monomethyl ether methacrylate) (PDPA-<i>b</i>-P(FPMA-<i>co</i>-OEGMA)) and DOX. The surface charge of the BCP-DOX micelles
reversed from negative to positive when encountering a weakly acidic
environment due to the protonation of PDPA segments. <i>In vitro</i> cellular uptake measurement shows that the cellular uptake and internalization
of the BCP-DOX micelles can be significantly enhanced at pH ∼
6.5. Moreover, this drug carrier exhibits a pH-dependent drug release
owing to the cleavage of the imine bond at pH < 5.5. With this
dual-pH responsive feature, these micelles may have the ability to
precisely deliver DOX to the cancer cells