Silver-Mediated Oxidative C–H/C–H Functionalization: A Strategy To Construct Polysubstituted Furans

A novel silver-mediated highly selective oxidative C–H/C–H functionalization of 1,3-dicarbonyl compounds with terminal alkynes for the creation of polysubstituted furans and pyrroles in one step has been demonstrated. Promoted by the crucial silver species, perfect selectivity and good to excellent yields could be achieved. This protocol represents an extremely simple and atom-economic way to construct polysubstituted furans and pyrroles from basic starting materials under mild conditions

Labile Cu(I) Catalyst/Spectator Cu(II) Species in Copper-Catalyzed C–C Coupling Reaction: Operando IR, in Situ XANES/EXAFS Evidence and Kinetic Investigations

Insights toward the Cu-catalyzed C–C coupling reaction were investigated through operando IR and in situ X-ray absorption near-edge structure/extended X-ray absorption fine structure. It was found that the Cu­(I) complex formed from the reaction of CuI with β-diketone nucleophile was liable under the cross-coupling conditions, which is usually considered as active catalytic species. This labile Cu­(I) complex could rapidly disproportionate to the spectator Cu­(II) and Cu(0) species under the reaction conditions, which was an off-cycle process. In this copper-catalyzed C–C coupling reaction, β-diketone might act both as the substrate and the ligand