85 research outputs found
LiDAR-Based Place Recognition For Autonomous Driving: A Survey
LiDAR-based place recognition (LPR) plays a pivotal role in autonomous
driving, which assists Simultaneous Localization and Mapping (SLAM) systems in
reducing accumulated errors and achieving reliable localization. However,
existing reviews predominantly concentrate on visual place recognition (VPR)
methods. Despite the recent remarkable progress in LPR, to the best of our
knowledge, there is no dedicated systematic review in this area. This paper
bridges the gap by providing a comprehensive review of place recognition
methods employing LiDAR sensors, thus facilitating and encouraging further
research. We commence by delving into the problem formulation of place
recognition, exploring existing challenges, and describing relations to
previous surveys. Subsequently, we conduct an in-depth review of related
research, which offers detailed classifications, strengths and weaknesses, and
architectures. Finally, we summarize existing datasets, commonly used
evaluation metrics, and comprehensive evaluation results from various methods
on public datasets. This paper can serve as a valuable tutorial for newcomers
entering the field of place recognition and for researchers interested in
long-term robot localization. We pledge to maintain an up-to-date project on
our website https://github.com/ShiPC-AI/LPR-Survey.Comment: 26 pages,13 figures, 5 table
An Artifact in Intracellular Cytokine Staining for Studying T Cell Responses and Its Alleviation.
Intracellular cytokine staining (ICS) is a widely employed ex vivo method for quantitative determination of the activation status of immune cells, most often applied to T cells. ICS test samples are commonly prepared from animal or human tissues as unpurified cell mixtures, and cell-specific cytokine signals are subsequently discriminated by gating strategies using flow cytometry. Here, we show that when ICS samples contain Ly6G+ neutrophils, neutrophils are ex vivo activated by an ICS reagent - phorbol myristate acetate (PMA) - which leads to hydrogen peroxide (H2O2) release and death of cytokine-expressing T cells. This artifact is likely to result in overinterpretation of the degree of T cell suppression, misleading immunological research related to cancer, infection, and inflammation. We accordingly devised easily implementable improvements to the ICS method and propose alternative methods for assessing or confirming cellular cytokine expression
Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status.
The role of neutrophils in solid tumor metastasis remains largely controversial. In preclinical models of solid tumors, both pro-metastatic and anti-metastatic effects of neutrophils have been reported. In this study, using mouse models of breast cancer, we demonstrate that the metastasis-modulating effects of neutrophils are dictated by the status of host natural killer (NK) cells. In NK cell-deficient mice, granulocyte colony-stimulating factor-expanded neutrophils show an inhibitory effect on the metastatic colonization of breast tumor cells in the lung. In contrast, in NK cell-competent mice, neutrophils facilitate metastatic colonization in the same tumor models. In an ex vivo neutrophil-NK cell-tumor cell tri-cell co-culture system, neutrophils are shown to potentially suppress the tumoricidal activity of NK cells, while neutrophils themselves are tumoricidal. Intriguingly, these two modulatory effects by neutrophils are both mediated by reactive oxygen species. Collectively, the absence or presence of NK cells, governs the net tumor-modulatory effects of neutrophils
One-2-3-45++: Fast Single Image to 3D Objects with Consistent Multi-View Generation and 3D Diffusion
Recent advancements in open-world 3D object generation have been remarkable,
with image-to-3D methods offering superior fine-grained control over their
text-to-3D counterparts. However, most existing models fall short in
simultaneously providing rapid generation speeds and high fidelity to input
images - two features essential for practical applications. In this paper, we
present One-2-3-45++, an innovative method that transforms a single image into
a detailed 3D textured mesh in approximately one minute. Our approach aims to
fully harness the extensive knowledge embedded in 2D diffusion models and
priors from valuable yet limited 3D data. This is achieved by initially
finetuning a 2D diffusion model for consistent multi-view image generation,
followed by elevating these images to 3D with the aid of multi-view conditioned
3D native diffusion models. Extensive experimental evaluations demonstrate that
our method can produce high-quality, diverse 3D assets that closely mirror the
original input image. Our project webpage:
https://sudo-ai-3d.github.io/One2345plus_page
Study and Simulation of Deformation Mechanics Modeling of Flexible Workpiece Processing by Rayleigh-Ritz Method
This paper discusses the calculation problems of bending deformation of FWP processing. Take three axis CNC machining as an example, to establish mechanics model of flexible workpiece processing process. The flexible workpiece balance equation is a two-dimensional partial differential equation, to solve the problem of flexible workpiece bending deformation using Rayleigh-Ritz method and designing the test function of bending deformation of flexible workpiece. By satisfying the minimum potential energy condition of FWP processing to work out the approximate solution of bending deformation of flexible workpiece, find out the relationship between material properties of flexible piece, acting force Fz, and deformation value. Finally, the rectangle flexible workpiece which is made up of polyurethane sponge is selected as an experiment subject. The results show that the average relative deviation between theoretical value and observed value is only 5.51%. It is proved that the bending deformation test function satisfies the actual deformation calculation requirements
Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis
Intrinsic stress response pathways are frequently mobilized within tumor cells. The mediators of these adaptive mechanisms and how they contribute to carcinogenesis remain poorly understood. A striking example is heat shock factor 1 (HSF1), master transcriptional regulator of the heat shock response. Surprisingly, we found that loss of the tumor suppressor gene neurofibromatosis type 1 (Nf1) increased HSF1 levels and triggered its activation in mouse embryonic fibroblasts. As a consequence, Nf1[superscript –/–] cells acquired tolerance to proteotoxic stress. This activation of HSF1 depended on dysregulated MAPK signaling. HSF1, in turn, supported MAPK signaling. In mice, Hsf1 deficiency impeded NF1-associated carcinogenesis by attenuating oncogenic RAS/MAPK signaling. In cell lines from human malignant peripheral nerve sheath tumors (MPNSTs) driven by NF1 loss, HSF1 was overexpressed and activated, which was required for tumor cell viability. In surgical resections of human MPNSTs, HSF1 was overexpressed, translocated to the nucleus, and phosphorylated. These findings reveal a surprising biological consequence of NF1 deficiency: activation of HSF1 and ensuing addiction to this master regulator of the heat shock response. The loss of NF1 function engages an evolutionarily conserved cellular survival mechanism that ultimately impairs survival of the whole organism by facilitating carcinogenesis.United States. Army Medical Research and Materiel Command (Neurofibromatosis Research Program)Kathy and Curt Marble Cancer Research Fun
The efficacy and mechanism of apoptosis induction by hypericin-mediated sonodynamic therapy in THP-1 macrophages
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