Comparison of ROC curves at 1-, 3-, 6-month and 1-year.

<p>Abbreviations: ROC, receiver operating characteristic curve; MELD, Model for End-Stage Liver Disease; D-MELD, the product of donor age and MELD; SOFT, Survival Outcome Following Liver Transplantation; BAR, Balance of Risk; TRI, Transplant Risk Index.</p

Clinical features of the study patients.

<p>NOTE: Values are expressed as number (%) or mean±SD. Abbreviations: SD, standard deviation; HBV, hepatitis B virus; HCV, hepatitis C virus; HCC, hepatocellular carcinoma; MHV, middle hepatic vein; ICU, intensive care unit; MELD, Model for End-Stage Liver Disease; D-MELD, the product of donor age and MELD; SOFT, Survival Outcome Following Liver Transplantation; BAR, Balance of Risk; TRI, Transplant Risk Index.</p><p>*Only 150 cases have the information of relationship</p><p>Clinical features of the study patients.</p

Preoperative Characteristics of Patients who underwent Hepatectomy.

<p>^*P<0.05 compared with the normal-weight BMI group. BMI:body mass index; HBsAg: hepatitis B surface antigen; HBeAg: hepatitis B e antigen; SD: standard deviation; ULN, upper limit of normal. ALT,alanine aminotransferase; AST, aspartate aminotransferase. ASA: American Society of Anesthesiologists category. IQR: interquartile range.</p

Independent prognostic factors for total complications according to logistic analysis.

<p>ALT: alanine aminotransferase; AST: aspartate aminotransferase. PRBCs: packed red blood cells.</p

Intraoperative Parameters of Patients who underwent Hepatectomy by Obesity Classification.

<p>BMI:body mass index;SD: standard deviation.PRBCs:packed red blood cells.</p

Postoperative Outcomes of Patients who underwent Hepatectomy.

<p>P<0.05 compared with the normal-weight BMI group. BMI: body mass index; ICU: Intensive Care Unit, IQR: interquartile range.</p

Efficacy and safety of anatomic resection versus nonanatomic resection in patients with hepatocellular carcinoma: A systemic review and meta-analysis

<div><p>Background</p><p>The surgical decision of performing anatomic resection (AR) or nonanatomic resection (NAR) in patients with hepatocellular carcinoma remains controversial. The aim of the current study is to conduct a meta-analysis on published results to compare surgical outcomes after AR and NAR.</p><p>Methods</p><p>A comprehensive search of the Pubmed, Ovid-Medline, Embase, Cochrane library, and Science Citation indexes was performed. Overall and disease free survival (DFS), perioperative mortality and morbidity were the main outcomes. The meta-analysis was performed using Revman 5.3 statistical software, and the results are expressed as the relative risk (RR) or weighted mean differences with 95% of confidence intervals.</p><p>Results</p><p>After application of the exclusion and inclusion criteria, 25 studies published between 1996~2015 that compared outcomes after AR and NAR in patients with HCC were identified. A total of 10216 patients were included in the meta-analysis, 4576 in the AR group and 5640 in the NAR group. Liver cirrhosis was found in 54.8% (range from 18.8% to 100%) of patients in the AR group and 67.8% (range from 34.3% to 100%) of patients in the NAR group, resulting in a RR of 0.45 (I2 = 18%, fixed model, 95% CI 0.39–0.52; Z = 10.31; P = <0.00001). The meta-analysis revealed a statistically significant 5-year survival (RR of 1.10, 95% CI 1.03–1.17; Z = 2.92, P = 0.004) and DFS (RR: 1.33, 95% CI 1.18–1.51; Z = 4.46, P <0.00001) advantage for patients undergoing AR resection compared to NAR. In regards to safety, no statistical significance was found in mortality and morbidity between the two groups. Eight studies including 1812 patients with small (<5 cm) solitary HCC indicated a better 5-year DFS in the AR group (41.4%) than in the NAR group (28.6%), with a RR of 1.32 (I2 = 42, fixed model, 95%CI: 1.15–1.52, Z = 3.86, P = 0.0001).</p><p>Conclusion</p><p>The current study demonstrates better surgical outcomes after AR than NAR in patients with HCC. Therefore, AR is recommended in resectable HCC, especially with small (<5 cm) solitary tumours.</p></div

Forest plot of the results of the meta-analysis comparing long-term outcomes of the two groups.

<p>(a) 5-year overall survival of the AR group versus the NAR group. (b) 5-year disease free survival of the AR group versus the NAR group.</p

Characteristics of the 25 studies included in the meta-analysis.

<p>Characteristics of the 25 studies included in the meta-analysis.</p

Flow diagram showing the search strategy along with the selection and screening processes for the eligible studies.

<p>Flow diagram showing the search strategy along with the selection and screening processes for the eligible studies.</p