1 research outputs found
Chalcone-Based Synthesis of Tetrahydropyridazines via Cloke–Wilson-Type Rearrangement-Involved Tandem Reaction between Cyclopropyl Ketones and Hydrazines
A facile
and efficient approach for the synthesis of multisubstituted
tetrahydropyridazines starting from cyclopropyl ketones and hydrazines
has been developed. The transformation is chalcone-based and takes
place via a Cloke–Wilson-type rearrangement-involved tandem
reaction catalyzed by TfOH in HFIP