Supplementary document for On-chip passive pump-rejection long-pass filters for integrated SiC-based nonlinear and quantum photonic chips - 6761975.pdf

supplemental documen

d‑Amino Acids Boost the Selectivity and Confer Supramolecular Hydrogels of a Nonsteroidal Anti-Inflammatory Drug (NSAID)

As systemically used therapeutics for treating acute or chronic pains or inflammations, nonsteroidal anti-inflammatory drugs (NSAIDs) also associate with the adverse gastrointestinal and renal effects and cardiovascular risks. Thus, it is beneficial to develop topical gels that selectively inhibit cyclooxygenase-2 (COX-2) for the management of local inflammation. In this work, we demonstrate that the covalent conjugation of d-amino acids to naproxen (i.e., a NSAID) not only affords supramolecular hydrogelators for the topical gels but also unexpectedly and significantly elevates the selectivity toward COX-2 about 20× at little expense of the activity of naproxen. This work illustrates a previously unexplored approach that employs d-amino acids for the development of functional molecules that have dual or multiple roles and exceptional biostability, which offers a new class of molecular hydrogels of therapeutic agents

Additional file 1 of Plasma exosomes improve peripheral neuropathy via miR-20b-3p/Stat3 in type I diabetic rats

Additional file 1: Figure S1. The diabetic model was successfully constructed after STZ injection. Figure S2. Internalization of plasma exosomes of sciatic nerve in NC rats. Figure S3. Biological distribution of plasma exosomes in vivo. Figure S4. Effects of plasma exosomes on RSC96 and DRG cells. Figure S5. Effects of plasma exosomes on RSC96 and DRG cells. Figure S6. Statistical analysis of pstat3/stat3. Figure S7. Characterization of ageing plasma exosomes. Figure S8. Ageing-exos did not improve nerve damage caused by high glucose. Figure S9. Ageing-exos augments the motor and sensory innervation of the targets. Table S1. Random blood glucose and total cholesterol levels after exosome treatment. Table S2. Random blood glucose and total cholesterol levels after miR-20b-3p agomir treatment. Table S3. Sequence information used in the article. Table S4. Reagent information used in the article

The asymmetrical items and their asymmetric indices related to the craniofacial hard tissue structure at the three time points before and after autogenous coronoid process graft reconstruction for the treatment of unilateral temporomandibular joint ankylosis.

<p>The asymmetrical items and their asymmetric indices related to the craniofacial hard tissue structure at the three time points before and after autogenous coronoid process graft reconstruction for the treatment of unilateral temporomandibular joint ankylosis.</p

Reduced smaller coronoid regeneration at the former site of the coronoid process resection (white arrow; A: T1 point; B: T2 point).

<p>Reduced smaller coronoid regeneration at the former site of the coronoid process resection (white arrow; A: T1 point; B: T2 point).</p

Upper airway measurements.

<p>Relevant 2D points and 10 items related to the midsagittal plane (A):ANS; PNS; ut; P; TT; E; MxPl; 1 Nasopas; 2 Velo Pasmin; 3 Oropas; 4 Hypopas; 5 SP position; 6 PNS-P; 7 SP thickness; 8 Ton length; 9 Ton height; 10 Ton position [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173142#pone.0173142.ref006" target="_blank">6</a>]. Relevant 3D points and 4 items related to volume (B):AH: the most anterosuperior point of the hyoid bone; MP: the plane passing Me, Go and Go’; VP: the plane crossing the anterior border of C3 and C4 and paralleling its long axis C3 and C4; AH-MP: the distance between AH and MP; AH(Z): the distance between AH and VP; Pasmin area: the smallest area of the cross section of the upper airway; Airway volume: the volume of upper airway between the Nasopas line and Hypopas line.</p

Maxillofacial hard tissue measurements.

<p>Relevant points and planes (ABC): N: the most concave and supreme point of nasofrontal suture; S: the center point of the sella turcica; Zy: the most lateral and supreme point of the zygomatic arch divided into Zy (i.e., the healthy side) and Zy’(i.e., the affected side); Co: the supreme point of the mandibular condyle divided into Co (i.e., the healthy side) and Co’ (i.e., the affected side); ANS: the point of the anterior nasal spine; Mx: the most interior and supreme point between the infrazygoma and the maxillary molar divided into Mx (i.e., the healthy side) and Mx’ (i.e., the affected side); PNS: the posterior-most point of the hard palate; A: the most concave point between the anterior nasal spine and the upper alveolar margin sagittally; Um: the most lateral point of first upper molar divided into Um (i.e., the healthy side) and Um’(i.e., the affected side); B: the most concave point of the anterior alveolar bone around lower incisors sagittally; Go: the posterior-most and nethermost point of the mandibular angle divided into Go (i.e., the healthy side) and Go’(i.e., the affected side); Me: the gnathion; Occ: the occlusal plane passing the two centers of the bilateral first upper molar overbite and the center of the central incisors overbite; MP: the plane passing Me, Go and Go’. Coordinate system (D):X: The horizontal plane crossing the straight line that rotated around N 7 degrees upward along NS and paralleled the two innermost points of the zygomaticofrontal suture on both sides; Y: The sagittal plane crossing N and the center point of the crista galli and perpendicular to X; Z: The coronal plane crossing N and perpendicular to X and Y. Fourteen integral items: SNA angle; SNB angle; ANB angle; Occ/X: the minor angle between Occ and X; MP/X: the minor angle between MP and X; ANS-PNS: the distance between ANS and PNS; N-Me(Y): the distance between N and the point that was projected by Me vertically on Z; N-ANS(Y): the distance between N and the point that was projected by ANS vertically on Z; ANS-Me(Y): the distance between two points that were projected by ANS and Me vertically on Z; Zy-Zy’/Y: the lower angle on tonic side between the line crossing Zy and Zy’ and Y; Mx-Mx’/Y: the lower angle on the tonic side between the line crossing Mx and Mx’ and Y; Go-Go’/Y: the lower angle on the tonic side between the line crossing Go and Go’ and Y; Occ/Y: the lower angle on tonic side between Occ and Y; Me(X): the vertical distance between Me and Y. Twelve asymmetrical items: Co-Me: the distance between Co and Me divided into Co-Me and Co’-Me; Go-Me: the distance between Go and Me divided into Go-Me and Go’-Me; Co-Go: the distance between Co and Go divided into Co-Go and Co’-Go’; Go-Me(Y): the distance between the two points that were projected by Go and Me vertically on Y and divided into Go-Me(Y) and Go’-Me(Y); Go(X): the vertical distance between Go and Y divided into Go(X) and Go’(X); Go(Y): the vertical distance between Go and X divided into Go(Y) and Go’(Y); Go(Z): the vertical distance between Go and Z divided into Go(Z) and Go’(Z); Co(X): the vertical distance between Co and Y divided into Co(X) and Co’(X); Co(Y): the vertical distance between Co and X divided into Co(Y) and Co’(Y); Co(Z): the vertical distance between Co and Z divided into Co(Z) and Co’(Z); Co-Go-Me: the angle consisting of Co, Go and Me divided into Co-Go-Me and Co’-Go’-Me; Um-Mx(Y): the distance between two points that were projected by Um and Mx vertically on Y and divided into Um-Mx(Y) and Um’-Mx’(Y).</p

Coronoid process graft remodeling.

<p>The coronoid process graft was absorbed, and contact bony formation was not obvious (A: T1 point; B: T2 point). Coronoid process graft absorption was not obvious, and boundary with the new bone tissue was visible (C: T1 point; D: T2 point). coronoid process graft bone hyperplasia with bony fusion (E: T1 point; F: T2 point).</p

Preoperative upper airways of autogenous coronoid process graft reconstruction for the treatment of unilateral temporomandibular joint ankylosis at three points (A: T0 point; B: T1 point; C: T2 point).

<p>Preoperative upper airways of autogenous coronoid process graft reconstruction for the treatment of unilateral temporomandibular joint ankylosis at three points (A: T0 point; B: T1 point; C: T2 point).</p

Introducing d‑Amino Acid or Simple Glycoside into Small Peptides to Enable Supramolecular Hydrogelators to Resist Proteolysis

Here we report the examination of two convenient strategies, the use of a d-amino acid residue or a glycoside segment, for increasing the proteolytic resistance of supramolecular hydrogelators based on small peptides. Our results show that the introduction of d-amino acid or glycoside to the peptides significantly increases the resistance of the hydrogelators against proteinase K, a powerful endopeptidase. The insertion of d-amino acid in the peptide backbone, however, results relatively low storage moduli of the hydrogels, likely due to the disruption of the superstructures of the molecular assembly. In contrast, the introduction of a glycoside to the C-terminal of peptide enhances the biostability of the hydrogelators without the significant decrease of the storage moduli of the hydrogels. This work suggests that the inclusion of a simple glycogen in hydrogelators is a useful approach to increase their biostability, and the gained understanding from the work may ultimately lead to development of hydrogels of functional peptides for biomedical applications that require long-term biostability