Hexaaqua­magnesium(II) bis­{[N-(4-meth­oxy-2-oxidobenzyl­idene)glycyl­glycinato(3−)]cuprate(II)} hexa­hydrate

In the title complex, [Mg(H2O)6][Cu(C12H11N2O5)]2·6H2O, the CuII atoms lie at the center of the square plane of triple negatively charged O,N,N′,O′-tetra­dentate Schiff base ligands, which are coordinated by one phenolate O atom, one imine N atom, one deprotonated amide N atom and one carboxyl­ate O atom. The MgII center, which sits on an inversion center, is coordinated by six aqua ligands and exhibits a slightly distorted octa­hedral conformation. The asymmetric unit consists of an [N-(4-meth­oxy-2-oxidobenzyl­idene)glycyl­glycinato]cuprate(II) anion, one half of an [Mg(H2O)6]2+ cation and three free water mol­ecules. The cations and anions form columns by O—H⋯O hydrogen bonds

Triaqua­bis{μ-N-[N-(4-meth­oxy-2-oxidobenzyl­idene)glyc­yl]glycinato(3−)}cadmium(II)dicopper(II) dihydrate

In the title compound, [CdCu2(C12H11N2O5)2(H2O)3]·2H2O, the CuII atoms are in a square plane of N2O2 atoms contributed by the tetra­dentate Schiff base trianion. The CuII atoms are coordinated by one phenolate O atom, one imine N atom, one amido N atom and one carboxyl­ate O atom. The CdII atom is connected via the carboxyl­ate groups, forming a heterotrinuclear CuII–CdII–CuII system. The CdII atom is seven-coordinate in a penta­gonal-bipyramidal geometry with four O atoms from two carboxyl­ate groups and three aqua ligands. The heterotrinuclear mol­ecules are linked to the uncoordinated water mol­ecules by O—H⋯O hydrogen bonds into a three-dimensional framework

Hexaaqua­cobalt(II) bis­{[N-(4-meth­oxy-2-oxidobenzyl­idene)glycylglycinato]nickel(II)} hexa­hydrate

In the title compound, [Co(H2O)6][Ni(C12H11N2O5)]2·6H2O, the NiII atom has a nearly square-planar coordination with two N and two O atoms of the N-(4-meth­oxy-2-oxidobenzyl­idene)glycylglycinate Schiff base ligand (L 3−). The CoII atom sits on an inversion center and is coordinated to six aqua ligands in a slightly distorted octa­hedral geometry. The [Co(H2O)6]2+ cations and [NiL]− anions form columns along the a axis by O—H⋯O hydrogen bonds. Additional hydrogen bonds between the uncoordinated and coordinated water molecules help to consolidate the crystal packing

Role of p53 in pseudorabies virus replication, pathogenicity, and host immune responses

International audienceAbstractAs a key cellular transcription factor that plays a central role in cellular responses to a broad range of stress factors, p53 has generally been considered as a host cell restriction factor for various viral infections. However, the defined roles of p53 in pseudorabies virus (PRV) replication, pathogenesis, and host responses remain unclear. In the present study, we initially constructed a p53 overexpressing a porcine kidney epithelial cell line (PK-15) to detect the effect of p53 on PRV replication in vitro. The results show that viral glycoprotein B (gB) gene copies and the titers of virus were significantly higher in p53 overexpressing PK-15 cells than in PK-15 and p53 inhibitor treated p53 overexpressing PK-15 cells. A similar result was also found in the p53 inhibitor PFT-α-treated PK-15 cells. We then examined the effects of p53 on PRV infection in vivo by using p53-knockout (p53−/−) mice. The results show that p53 knockout not only led to significantly reduced rates of mortality but also to reduced viral replication and development of viral encephalitis in the brains of mice following intracranial inoculation. Furthermore, we examined the effect of p53 knockout on the expression of the reported host cell regulators of PRV replication in the brains of mice by using RNA sequencing. The results show that p53 knockout downregulated the interferon (IFN) regulator genes, chemokine genes, and antiviral genes after PRV infection. This finding suggests that p53 positively regulates viral replication and pathogenesis both in vitro and in vivo. These findings offer novel targets of intrinsic host cell immunity for PRV infection

Intestinal Microecology in Pediatric Surgery-Related Gastrointestinal Diseases Current Insights and Future Perspectives

Intestinal microecology is established from birth and is constantly changing until homeostasis is reached. Intestinal microecology is involved in the immune inflammatory response of the intestine and regulates the intestinal barrier function. The imbalance of intestinal microecology is closely related to the occurrence and development of digestive system diseases. In some gastrointestinal diseases related to pediatric surgery, intestinal microecology and its metabolites undergo a series of changes, which can provide a certain basis for the diagnosis of diseases. The continuous development of microecological agents and fecal microbiota transplantation technology has provided a new means for its clinical treatment. We review the relationship between pathogenesis, diagnosis and treatment of pediatric surgery-related gastrointestinal diseases and intestinal microecology, in order to provide new ideas and methods for clinical diagnosis, treatment and research

A short literature review on workplace discrimination

Treball fi de màster de: Master's Degree in Economics and Finance. Curs 2021-2022Tutor: Kadir OzenIn this literature review, we focus on workplace discrimination with particular attention paid to the hiring process. We classified the hiring process into two stages: CV-screening and interview. Following the theoretical discussion of stereotypes supporting the existence of discrimination, two empirical pieces of research are introduced: the first paper shows that race affects applicants’ callback rate during the screening process, while the second study shows that the probability of a female musician being hired increases with the introduction of blind auditions. Lastly, from a sociological aspect, we claim that cultural similarities can affect employers’ hiring decisions, from which workplace discrimination might also appear.En esta revisión de la literatura, nos enfocamos en la discriminación en el lugar de trabajo con especial atención al proceso de contratación. Clasificamos el proceso de contratación en dos etapas: selección de CV y entrevista. Siguiendo la discusión teórica de los estereotipos que respaldan la existencia de discriminación, se presentan dos investigaciones empíricas: el primer artículo muestra que la raza influencia la probabilidad de conseguir entrevistas de trabajo, mientras que el segundo estudio muestra que la probabilidad de que una música sea contratada aumenta con la introducción de audiciones a ciegas. Por último, desde un aspecto sociológico, afirmamos que las similitudes culturales pueden afectar las decisiones de contratación de los empleadores, augmentando la discriminación laboral

Intelligent Bearing Fault Diagnosis Based on Multivariate Symmetrized Dot Pattern and LEG Transformer

Deep learning based on vibration signal image representation has proven to be effective for the intelligent fault diagnosis of bearings. However, previous studies have focused primarily on dealing with single-channel vibration signal processing, which cannot guarantee the integrity of fault feature information. To obtain more abundant fault feature information, this paper proposes a multivariate vibration data image representation method, named the multivariate symmetrized dot pattern (M-SDP), by combining multivariate variational mode decomposition (MVMD) with symmetrized dot pattern (SDP). In M-SDP, the vibration signals of multiple sensors are simultaneously decomposed by MVMD to obtain the dominant subcomponents with physical meanings. Subsequently, the dominant subcomponents are mapped to different angles of the SDP image to generate the M-SDP image. Finally, the parameters of M-SDP are automatically determined based on the normalized cross-correlation coefficient (NCC) to maximize the difference between different bearing states. Moreover, to improve the diagnosis accuracy and model generalization performance, this paper introduces the local-to-global (LG) attention block and locally enhanced positional encoding (LePE) mechanism into a Swin Transformer to propose the LEG Transformer method. Then, a novel intelligent bearing fault diagnosis method based on M-SDP and the LEG Transformer is developed. The proposed method is validated with two experimental datasets and compared with some other methods. The experimental results indicate that the M-SDP method has improved diagnostic accuracy and stability compared with the original SDP, and the proposed LEG Transformer outperforms the typical Swin Transformer in recognition rate and convergence speed