Additional file 7: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

The potential regulatory microRNAs. The results for each enriched gene set of predicted microRNA are listed in this excel. For each predicted microRNA, the information including the microRNA name, corresponding Gene Set ID, number of target genes of each microRNA, p value from hypergeometric test, p value adjusted by the multiple test adjustment, as well as target genes of each microRNA are listed. (XLSX 18 kb

Additional file 6: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

KEGG pathways enriched by differentially expressed genes. The results for each enriched KEGG pathway are listed in this excel. For each KEGG pathway, the information including KEGG pathway name, corresponding KEGG ID, number of genes in the gene set and also in the category, p value from hypergeometric test, p value adjusted by the multiple test adjustment, as well as genes in the pathway are listed. (XLSX 14 kb

Additional file 1: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

Differentially expressed genes identified by RNA-seq. The excel lists a total of 400 probes with the expression level changed, and those probes involved 321 differentially expressed genes between estrogen-treated intraluminal middle cerebral artery occlusion (MCAO) rat group and untreated MCAO rat group (p-value < 0.05). (XLSX 42 kb

Additional file 2: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

The interaction pairs of nodes in protein-protein interaction network. This excel presents 243 nodes and 590 interaction pairs (combined score > 0.4) in Fig. 1. In addition, it contains the combined score values of these 590 interaction pairs. (XLSX 61 kb

Additional file 5: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

GO items enriched by up-regulated and down-regulated differentially expressed genes. The excel provides the following information in detail, including the names of 25 GO terms enriched by up-regulated genes and 18 GO terms enriched by down-regulated genes, and category, count, p value and adjusted p values for each GO term, as well as the genes list that enriched in GO term. (XLSX 16 kb

Additional file 3: of Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

The degrees of nodes in protein-protein interaction network. The excel describes the up/down-regulated status and degrees of 243 nodes in the PPI network. A total of 119 nodes were up-regulated genes and 124 nodes were down-regulated genes. The nodes degrees were ranged from 37 to 1. (XLSX 227 kb