Towards Generalized Multi-stage Clustering: Multi-view Self-distillation

Existing multi-stage clustering methods independently learn the salient features from multiple views and then perform the clustering task. Particularly, multi-view clustering (MVC) has attracted a lot of attention in multi-view or multi-modal scenarios. MVC aims at exploring common semantics and pseudo-labels from multiple views and clustering in a self-supervised manner. However, limited by noisy data and inadequate feature learning, such a clustering paradigm generates overconfident pseudo-labels that mis-guide the model to produce inaccurate predictions. Therefore, it is desirable to have a method that can correct this pseudo-label mistraction in multi-stage clustering to avoid the bias accumulation. To alleviate the effect of overconfident pseudo-labels and improve the generalization ability of the model, this paper proposes a novel multi-stage deep MVC framework where multi-view self-distillation (DistilMVC) is introduced to distill dark knowledge of label distribution. Specifically, in the feature subspace at different hierarchies, we explore the common semantics of multiple views through contrastive learning and obtain pseudo-labels by maximizing the mutual information between views. Additionally, a teacher network is responsible for distilling pseudo-labels into dark knowledge, supervising the student network and improving its predictive capabilities to enhance the robustness. Extensive experiments on real-world multi-view datasets show that our method has better clustering performance than state-of-the-art methods

Association between N, N-diethyl-m-toluamide exposure and the odds of kidney stones in US adults: a population-based study

BackgroundCurrently, there is limited research on the specific relationship between N, N-diethyl-m-toluamide (DEET) exposure and the odds of kidney stones. We aimed to investigate the relationship between DEET exposure and the prevalence of kidney stones.MethodsWe included 7,567 qualified participants in our research from the 2007–2016 NHANES survey. We carried out three logistic regression models to explore the potential association between DEET exposure and the odds of kidney stones. Spline smoothing with generalized additive models (GAM) was utilized to assess the non-linear relationship and restricted cubic spline (RCS) curves was to determine the dose–response association. Multivariate regression models were used to conduct stratified analysis and sensitivity analysis.ResultsBaseline characteristics of study participants presented the distribution of covariables. Regression analysis revealed that the odds of kidney stones were positively associated with the main metabolites of 3-diethyl-carbamoyl benzoic acid (DCBA) (log2) (OR = 1.05, 95% CI 1.02 to 1.08). The fourth quartile of urine DCBA showed a greater risk of kidney stones in the fully adjusted model (OR = 1.36, 95% CI 1.08 to 1.72). Another DEET metabolite of N, N-diethyl-3-hydroxymethylbenzamide (DHMB) was used to confirm the accuracy and stability of the results. The spline smoothing curve represented two main DEET metabolites had similar no-linear relationships and a positive trend with kidney stones proportion. RCS implied that the incidence of kidney stones rose with increasing levels of DEET exposure. High-risk groups on kidney stones were exhibited by stratified analysis under DEET exposure.ConclusionOur study suggests that DEET exposure is positively associated with odds of kidney stones. Further investigation into the underlying processes of this association is required to guide the prevention and treatment of kidney stones

Synthesis of single-crystal La0.67Sr0.33MnO3 freestanding films with different crystal-orientation

We report the synthesis of single-crystal La0.67Sr0.33MnO3 (LSMO) freestanding films with different crystal orientations. By using pulsed laser deposition, water soluble perovskite-like sacrificial layers Sr3Al2O6 (SAO) followed by LSMO films are grown on differently oriented SrTiO3 substrates. Freestanding LSMO films with different orientations are obtained by etching the SAO in pure water. All the freestanding films show room-temperature ferromagnetism and metallicity, independent of the crystal orientation. Intriguingly, the Curie temperature (TC) of the freestanding films is increased due to strain relaxation after releasing from the substrates. Our results provide an additional degree of freedom to tailor the properties of freestanding perovskite oxide heterostructures by crystal orientation and an opportunity to further integrate different oriented films together

Causative agent distribution and antibiotic therapy assessment among adult patients with community acquired pneumonia in Chinese urban population

<p>Abstract</p> <p>Background</p> <p>Knowledge of predominant microbial patterns in community-acquired pneumonia (CAP) constitutes the basis for initial decisions about empirical antimicrobial treatment, so a prospective study was performed during 2003–2004 among CAP of adult Chinese urban populations.</p> <p>Methods</p> <p>Qualified patients were enrolled and screened for bacterial, atypical, and viral pathogens by sputum and/or blood culturing, and by antibody seroconversion test. Antibiotic treatment and patient outcome were also assessed.</p> <p>Results</p> <p>Non-viral pathogens were found in 324/610 (53.1%) patients among whom <it>M. pneumoniae </it>was the most prevalent (126/610, 20.7%). Atypical pathogens were identified in 62/195 (31.8%) patients carrying bacterial pathogens. Respiratory viruses were identified in 35 (19%) of 184 randomly selected patients with adenovirus being the most common (16/184, 8.7%). The nonsusceptibility of <it>S. pneumoniae </it>to penicillin and azithromycin was 22.2% (Resistance (R): 3.2%, Intermediate (I): 19.0%) and 79.4% (R: 79.4%, I: 0%), respectively. Of patients (312) from whom causative pathogens were identified and antibiotic treatments were recorded, clinical cure rate with β-lactam antibiotics alone and with combination of a β-lactam plus a macrolide or with fluoroquinolones was 63.7% (79/124) and 67%(126/188), respectively. For patients having mixed <it>M. pneumoniae </it>and/or <it>C. pneumoniae </it>infections, a better cure rate was observed with regimens that are active against atypical pathogens (e.g. a β-lactam plus a macrolide, or a fluoroquinolone) than with β-lactam alone (75.8% vs. 42.9%, <it>p </it>= 0.045).</p> <p>Conclusion</p> <p>In Chinese adult CAP patients, <it>M. pneumoniae </it>was the most prevalent with mixed infections containing atypical pathogens being frequently observed. With <it>S. pneumoniae</it>, the prevalence of macrolide resistance was high and penicillin resistance low compared with data reported in other regions.</p

HeterBot: A heterogeneous mobile manipulation robot for versatile operation

Abstract This study presents the overall architecture of HeterBot, a heterogeneous mobile manipulation robot developed in our lab, which is designed for versatile operation in hazardous environments. The most significant feature of HeterBot is the heterogeneous design created by adopting the idea of ‘big arm + small arm’ and ‘big car + mini car’. This combination has the advantage of functional complementation, which achieves performance promotion in both locomotion and manipulation capabilities, making HeterBot distinguished from other mobile manipulation robots. Besides, multiple novel technologies are integrated into HeterBot to expand its versatility and ease of use, including Virtual Robot Experimentation Platform‐based teleoperation, reconfigurable end effectors, laser‐aided grasping, and manipulation with customised tools. Experimental results validate the effectiveness of HeterBot in various locomotion and manipulation tasks. HeterBot displays huge potential in future applications, such as searching and rescue

Subsidence Monitoring of Fill Area in Yan’an New District Based on Sentinel-1A Time Series Imagery

In recent years, many cities in the Chinese loess plateau (especially in Shanxi province) have encountered ground subsidence problems due to the construction of underground projects and the exploitation of underground resources. With the completion of the world’s largest geotechnical project, called “mountain excavation and city construction,” in a collapsible loess area, the Yan’an city also appeared to have uneven ground subsidence. To obtain the spatial distribution characteristics and the time-series evolution trend of the subsidence, we selected Yan’an New District (YAND) as the specific study area and presented an improved time-series InSAR (TS-InSAR) method for experimental research. Based on 89 Sentinel-1A images collected between December 2017 to December 2020, we conducted comprehensive research and analysis on the spatial and temporal evolution of surface subsidence in YAND. The monitoring results showed that the YAND is relatively stable in general, with deformation rates mainly in the range of −10 to 10 mm/yr. However, three significant subsidence funnels existed in the fill area, with a maximum subsidence rate of 100 mm/yr. From 2017 to 2020, the subsidence funnels enlarged, and their subsidence rates accelerated. Further analysis proved that the main factors induced the severe ground subsidence in the study area, including the compressibility and collapsibility of loess, rapid urban construction, geological environment change, traffic circulation load, and dynamic change of groundwater. The experimental results indicated that the improved TS-InSAR method is adaptive to monitoring uneven subsidence of deep loess area. Moreover, related data and information would provide reference to the large-scale ground deformation monitoring and in similar loess areas

Applicability of RANS models and pressure drop in edge subchannels for 19-pin wire-wrapped fuel bundle channel in CiADS

The accelerator-driven subcritical system has a strong transmutation ability and high inherent safety, and it is internationally recognized as the most promising long-life nuclear waste disposal device. This study involves the construction of a Visual Hydraulic ExperimentaL Platform (VHELP) for the purpose of evaluating the applicability of Reynolds-averaged Navier–Stokes (RANS) models and analyzing the pressure distribution within the fuel bundle channel of China initiative accelerator-driven system (CiADS). Measurements of thirty differential pressures in edge subchannels within a 19-pin wire-wrapped fuel bundle channel were obtained under different conditions using deionized water. The pressure distribution in the fuel bundle channel at Reynolds numbers of 5000, 7500, 10,000, 12,500, and 15,000 was simulated using Fluent. The results show that RANS models obtained accurate results, and the shear stress transport k-ω model provided the most accurate prediction of the pressure distribution. The difference between the results of the Shear stress transport (SST) k-ω model and experimental data was the smallest, and the maximum difference was ±5.57%. Moreover, the error between the experimental data and numerical results of the axial differential pressure was smaller than that of the transverse differential pressure. The pressure periodicity in axial and transverse directions (one pitch) and a relatively three-dimensional pressure measurements were studied. The static pressure fluctuated and decreased periodically as the z-axis coordinate increased. These results can facilitate research on the cross-flow characteristics of liquid metal-cooled fast reactors

Two Distinct C-Type Lysozymes in Goldfish: Molecular Characterization, Antimicrobial Potential, and Transcriptional Regulation in Response to Opposing Effects of Bacteria/Lipopolysaccharide and Dexamethasone/Leptin

Lysozymes are key antimicrobial peptides in the host innate immune system that protect against pathogen infection. In this study, the full-length cDNAs of two c-type lysozymes (gfLyz-C1 and gfLyz-C2) were cloned from goldfish (Carassius auratus). The structural domains, three-dimensional structures, and amino acid sequences of gfLyz-C1 and gfLyz-C2 were highly comparable, as the two proteins shared 89.7% sequence identity. The gfLyz-C1 and gfLyz-C2 recombinant proteins were generated in the insoluble fractions of an Escherichia coli system. Based on the results of lysoplate and turbidimetric assays, gfLyz-C1 and gfLyz-C2 showed broad-spectrum antimicrobial properties with high levels of activity against Micrococcus lysodeikticus, Vibrio parahemolyticus, and Edwardsiella tarda, and relatively low activity against E. coli. Both gfLyz-C1 and gfLyz-C2 mRNAs were mainly expressed in the trunk kidney and head kidney, and gfLyz-C1 was expressed at much higher levels than gfLyz-C2 in the corresponding tissues. The expression of the gfLyz-C1 and gfLyz-C2 transcripts in the trunk kidney and head kidney was induced in these tissues by challenge with heat-inactivated E. coli and lipopolysaccharides (LPS), and the transcriptional responses of gfLyz-C1 were more intense. In goldfish primary trunk kidney cells, the levels of the gfLyz-C1 and gfLyz-C2 transcripts were upregulated by heat-inactivated E. coli, V. parahemolyticus, and E. tarda, as well as LPS, and downregulated by treatment with dexamethasone and leptins. Overall, this study may provide new insights that will improve our understanding of the roles of c-type lysozymes in the innate immunity of cyprinid fish, including the structural and phylogenetic characteristics, antimicrobial effects, and regulatory mechanism